Alervil (pheniramine maleate) / Incepta Pharma - LARVOL DELTA

Kounis Syndrome after Oral Amoxicillin Clavulanate. (PubMed, Int J Appl Basic Med Res) - "Electrocardiogram (ECG) showed ST segment changes along with elevated troponin I. Suspecting Kounis syndrome, she was administered pheniramine maleate, hydrocortisone, and oral antiplatelets along with intravenous fluids. She recovered completely and was discharged after 48 h. This case highlights coronary vasospasm during an ongoing allergic reaction and its management with antihistamines, steroids, and antiplatelet drugs. Nebulized adrenaline was safely given with ECG monitoring for airway edema."

Journal • Allergy • Cardiovascular • Hematological Disorders • Immunology • Thrombosis

Retrograde Venous Perfusion Augments Healing of Chronic Venous Leg Ulcers: A Randomized Controlled Trial. (PubMed, Int J Low Extrem Wounds) - "Drugs used for RVP were prostaglandin E1 (alprostadil), calcium heparin, hydrocortisone, pheniramine maleate, and lidocaine. It offered positive results with regard to improved healing outcomes and reduced ulcer size. More researches are needed to confirm these conclusions."

Journal • Infectious Disease • Venous Ulcer

Evaluation of the pain level felt by patients during intramuscular injection in the emergency department and the pain-drug relationship (EUSEM 2024) - "When the two groups were compared in terms of age and pain score, no statistically significant difference was detected between the groups (p : 0.233, p : 0.284).The most common drug administrations to the patients participating were diclofenac sodium 221 (77%), dexketoprofen 35 (12.2%), pheniramine maleate 24 (8.4%) and others 7 (2.4%). Conclusions : When the relationship between diclofenac and dexketoprofen active substance agents, which are frequently preferred in the treatment of pain by intramuscular injection in our country's emergency departments, and pain, we found that patients who received dexketoprofen felt more pain. We determined that the patient's breath holding during the im injection application had no effect on the pain score."

Clinical • Anesthesia • Pain

Rare Paediatric Dermatoses: A Case Series (EADV 2024) - "Antecedent history of trauma and infection was present in each episode which were controlled by injectable hydrocortisone and pheniramine maleate...She was well controlled on oral tranexamic acid... Each condition presents unique challenges and requires tailored management strategies including genetic analysis where required."

Clinical • Anemia • Cardiovascular • Dermatology • Dermatopathology • Hematological Disorders • Hereditary Angioedema • Infectious Disease • Mood Disorders • Oncology • Otorhinolaryngology • Pediatrics • SOS1

Interventions for postburn pruritus. (PubMed, Cochrane Database Syst Rev) - "There is moderate to low-certainty evidence on the effects of 21 interventions. Most studies were small and at a high risk of bias related to blinding and incomplete outcome data. Where there is moderate-certainty evidence, practitioners should consider the applicability of the evidence for their patients."

Clinical • Journal • Review • Dermatology • Pain • Pruritus

The First Case Report of 12-Step 3-Bag Successful Rapid Drug Desensitization to Daratumumab in a Patient with Renal Failure Due to Secondary Systemic Amyloid and Plasma Cell Dyscrasia (EAACI 2024) - "Peroral premedication with 1 mg/kg methylprednisolone, 40 mg famotidine, 10 mg montelukast, and 10 mg loratadine 72 hours before RDD, plus 1 mg/kg methylprednisolone, 45.5 mg pheniramine maleate, and 1000 mg paracetamol 30 minutes before RDD were administered. Our case reports the first 12-step 3-bag RDD experience applied to a multiple myeloma case diagnosed with secondary systemic amyloidosis and renal failure. Even if the drug hypersensitivity reaction is IgE/non-IgE mediated, RDD should be tried if alternative/superior treatment is not available."

Case report • Clinical • Allergy • Immunology

Development of cisplatin anaphylaxis despite omalizumab premedication: a case of chemotherapy desensitization (EAACI 2024) - "Desensitization was performed with cisplatin 130 mg using the 12-step Mariana Castells protocol, including premedication 13-7-1 hours before, consisting of 40 mg intravenous methylprednisolone, pantoprazole tablet, montelukast tablet, and fexofenadine tablet during steps 8-9 and 11-12...After ceasing chemotherapy, administering methylprednisolone 40 mg IV, and pheniramine maleate 45.5 mg IM, the patient experienced abdominal pain, nausea, and cold sweats...The patient was closely monitored in the intensive care unit for a day, and upon stabilization, was discharged, advising against platinum-based treatment due to cisplatin-induced anaphylaxis. 22638"

Clinical • Late-breaking abstract • Allergy • Immunology

Proportion of Over-The-Counter Medicines Containing a Plant Component and Those with Synthetic Substances Administered among Children in a Bulgarian Population. (PubMed, Pharmaceuticals (Basel)) - "Some of these medicines also contain substances such as antihistamines (pheniramine maleate) and decongestants (pseudoephedrine, phenylephrine hydrochloride, dimetidine) that can cause various unwanted side effects. Considering the aforementioned aspects and also the peculiarities of childhood, we recommend that self-treatment be conducted only after consulting a health specialist."

Journal • Cough • Pain • Respiratory Diseases

Application of multivariate chemometrics tools for spectrophotometric determination of naphazoline HCl, pheniramine maleate and three official impurities in their eye drops. (PubMed, Sci Rep) - "The proposed models could determine NZ and PN with respective detection limits of 0.447 and 1.750 μg mL for PLS, and 0.494 and 2.093 μg mL for ANN. The two established models were compared favorably with official methods where no significant difference observed."

Journal

Comparative Assessment of Hypersensitivity Reactions on Use of Latex and Nitrile Gloves Among General Dental Practitioners: A Cross-Sectional Study. (PubMed, Cureus) - "Among 356 participants 175 showed symptoms by the use of both latex and nitrile gloves, out of which 85.14% showed allergy to latex and 14.85% to nitrile gloves. All 175 individuals showed type IV hypersensitivity, and none of them showed type I. Conclusion Latex gloves are not the only option for dentists who experience itching when wearing gloves; they can also use powered-free latex gloves and nitrile gloves or take precautions such as not using oil-based cream, washing their hands, or taking pharmaceuticals such as cetirizine, pheniramine maleate, etc. However, when symptoms worsen and include erythema, swelling, wheezing, and in some cases, anaphylactic shock may occur they tend to use alternative gloves."

Journal • Observational data • Allergy • Dermatology • Immunology

Ribociclib-induced cutaneous vasculitis and pancytopenia in a patient with breast cancer (EADV-Sp 2023) - "0.5 mg/kg prednisolone intravenously (iv), topical mometasone furoat cream and iv pheniramine maleate were started...We found two cases with vasculitis induced by other cyclin-dependent kinases 4/6, one is due to palbociclib and other is due to abemaciclib. To the our knowledge, this is the first case of vasculitis induced by ribociclib. 18 MAY - 20 MAY 2023 POWERED BY M-ANAGE.COM"

Clinical • Alopecia • Anemia • Breast Cancer • Dermatology • Hematological Disorders • HER2 Breast Cancer • HER2 Negative Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Infectious Disease • Neutropenia • Oncology • Solid Tumor • Steven-Johnson Syndrome • Thrombocytopenia • Vasculitis • Vitiligo • HER-2

Evaluation of MONOFER-induced hypersensitive reactions: A retrospective cohort study. (PubMed, J Pak Med Assoc) - "Iron deficiency is the most common cause of anaemia. A total of 43 (68.25%) participants who experienced hypersensitivity reactions showed clinical symptoms within one hour, 11(17.46%) showed reaction in 1-3 hours and 9 (14.29%) showed in > 3 Hours. The majority of the studied population showed significant improvement only after the administration of Pheniramine maleate, while only a few of them received Hydrocortisone."

Journal • Retrospective data • Hematological Disorders • Immunology

Effect of pheniramine maleate on rat skeletal muscle ischemia-reperfusion injury. (PubMed, Ulus Travma Acil Cerrahi Derg) - "Ph is effective at reducing experimental rat skeletal muscle IRI."

Journal • Preclinical • Cardiovascular • Reperfusion Injury • CAT • MPO • PARP1

Understanding ocular comfort differences between 0.7% olopatadine and 0.3% pheniramine maleate/0.025% naphazoline hydrochloride eye drops. (PubMed, Clin Exp Optom) - "There were no between drop differences in visual acuity, though eyes treated with VISINE were less red than eyes treated with Pataday. Topically applied Pataday drops were more comfortable than VISINE drops."

Journal • Allergy • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology

Insulin Desensitization as an Effective Solution to Human Insulin Hypersensitivity and Its Associated Insulin Resistance (EAACI 2022) - "Prior to this RDD, the patient had shown an apparently relative resistance to insulin injections, where RBS was constantly very high not responding to insulin injections properly even while accompanied with pheniramine maleate injections... To our knowledge, this is the first insulin rapid desensitization case in Egypt. Human insulin RDD using CSII is a safe and effective method to manage insulin hypersensitivity, DKA and abolish the associated insulin resistance. Insulin RDD is a very challenging procedure due to the restriction of using corticosteroids to control breakthrough reactions."

Immunology

Patient-Reported Symptoms Associated with Over-the-Counter Allergy Eye Drops (ASCRS-ASOA 2022) - "The Purpose of this work was to evaluate a patient’s perceived ocular comfort after application of topical 0.7% olopatadine compared to 0.035% ketotifen fumarate or 0.3% pheniramine maleate/0.025% naphazoline hydrochloride. Both studies found that participants were numerically more likely to report that they strongly preferred or preferred 0.7% olopatadine over the comparison drops for all Likert symptoms evaluated except for vision fluctuation/blur, which was similar between 0.7% olopatadine and 0.3% pheniramine maleate. Conclusion Topical 0.7% olopatadine appears to be more comfortable and result in less ocular symptoms than 0.035% ketotifen fumarate or 0.3% pheniramine maleate, which suggests that patients may be more likely to comply with topical 0.7% olopatadine than its common market competitors."

Clinical • Allergy • Immunology

A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities. (PubMed, BMC Chem) - "Method greenness was evaluated and compared to the reported HPLC one via environmental, health and safety tool. The developed method has much potential over the reported one of being simple, selective, economic and time saving for the analysis of the five cited compounds."

Journal

Efonidipine-Induced Exanthematic Drug Eruption and Literature Review. (PubMed, J Cardiovasc Pharmacol) - "In view of her hypertension and left anterior descending artery stenosis, she was initiated on aspirin, clopidogrel, atorvastatin, pantoprazole, nebivolol, aldactone, and efonidipine a week ago. Her presenting complaints were initially managed with parenteral pheniramine maleate and hydrocortisone...She was prescribed topical beclomethasone and oral antihistamines for better control of her symptoms...World Health Organization-Uppsala Monitoring Centre causality assessment criteria indicated a "certain" association. To the best of the knowledge of the authors, this is one among the first reported cases of efonidipine-induced exanthematic drug eruption."

Journal • Dermatology • Dermatopathology

[VIRTUAL] Allergenic response of whole-body allergen extract of black ant in a pediatric patient (EAACI 2020) - "Pheniramine Maleate with supportive treatment...Instructions for ant-bite avoidance were given with prescription of epinephrine and directions for its appropriate use... Allergen sublingual immunotherapy can be a safe and effective therapy in such patients of insects bites with systemic reaction to insect bites."

Clinical • Allergy • Immunology

Is there enough naloxone to deter the diversion? Effect of concurrent administration of intravenous naloxone on opioid agonist effects of intravenous buprenorphine: A randomised, double-blind, within-subject, crossover study among opioid-dependent subjects. (PubMed, Drug Alcohol Rev) - "The 4:1 BNX condition did not impact the reinforcing agonist effects of buprenorphine. None of the intravenous BNX combination ratios precipitated opioid withdrawals. Findings emphasise the need for exploring more abuse deterrent mechanisms."

Clinical • Journal

Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal (clinicaltrials.gov) - P3; N=132; Completed; Sponsor: EMS; N=212 ➔ 132

Clinical • Enrollment change