amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Amoxicillin-induced Erythema Scarlatiniforme Desquamativum Recidivans with cross-reactivity to cefadroxil in a child: A case report and review of literature. (PubMed, Br J Clin Pharmacol) - "This case establishes the first report of generalized ESDR triggered by amoxicillin in a paediatric patient. It emphasizes a unique pattern of drug hypersensitivity, characterized by cross-reactivity to cefadroxil and tolerance to other tested penicillins (phenoxymethylpenicillin and oxacillin). It is essential to conduct a complete allergy work-up, which includes OPTs, to conduct a customized cross-reactivity assessment. This assessment is essential for the safe guidance of future therapeutic decisions in patients with drug-induced ESDR."

Journal • Allergy • Dermatology • Immunology • Pediatrics

PEN-DEL: implementing penicillin allergy de-labeling in hospitalized older adults - a quality improvement initiative. (PubMed, Antimicrob Steward Healthc Epidemiol) - "Only 1 patient experienced a delayed reaction to amoxicillin-clavulanate. From surveying ACE unit nursing, physician, and pharmacy staff, frequently reported barriers to allergy assessment and de-labeling included time and staffing constraints, and patient complexity. Our pharmacy-driven interdisciplinary penicillin allergy de-labeling initiative is effective and safe for eligible hospitalized older adults with low PEN-FAST scores (≤1)."

Journal • Allergy • Immunology • Infectious Disease

Antimicrobial Resistant Isolates in Surgical and Bite Wounds in Dogs and Cats: A 12-Year Retrospective Analysis. (PubMed, Animals (Basel)) - "High resistance rates were recorded for amoxicillin-clavulanate, cephalexin, enrofloxacin, and marbofloxacin. Resistance to carbapenems remained low. Although samples were limited, these findings underscore the ongoing impact of AMR in surgical and bite wounds and highlight the importance of implementing rigorous antimicrobial stewardship practices in veterinary medicine."

Journal • Retrospective data • Infectious Disease • Pneumonia

Nocardia Otomastoiditis in a Chemotherapy-Induced Neutropenic Patient With Diffuse Large B-cell Lymphoma: Successful Medical Management. (PubMed, Cureus) - "She had a 15-year history of intermittent otorrhea, previously treated with oral amoxicillin-clavulanate with transient improvement. Computed tomography (CT) imaging demonstrated otomastoiditis without bony erosion or intracranial extension.  The patient was treated with a brief empiric course of intravenous imipenem, followed by eight weeks of oral TMP-SMX, resulting in the complete resolution of clinical symptoms and significant radiologic improvement.  This case highlights the importance of considering Nocardia infection in patients with chronic or refractory otorrhea, particularly in the setting of chemotherapy-induced neutropenia. An early microbiologic diagnosis and focused therapy can lead to complete healing without surgery or long-term use of multiple drugs."

Journal • B Cell Lymphoma • Chemotherapy-Induced Neutropenia • Diffuse Large B Cell Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology

Successful treatment of pulmonary melioidosis in an Australian dog. (PubMed, Aust Vet J) - "Antimicrobial therapy included amoxicillin clavulanic-acid (AMC) (day 1-21, then day 28-84), trimethoprim sulfadiazine (day 8-28), enrofloxacin (day 2-16) and doxycycline (day 8-16). There was no evidence of recurrence during the follow-up period, and the dog died of unrelated causes 785 days after the original presentation. This case is the first description of successful treatment of canine pulmonary melioidosis in a region not previously associated with high endemicity."

Journal • Infectious Disease • Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases

NECROTIZING INFECTION BY LACTOBACILLUS ACIDOPHILUS: FRIEND OR FOE (WRMC 2026) - "She initially received oral clindamycin prescribed by her primary care physician without improvement...Based on these results, her antimicrobial regimen was narrowed to intravenous ampicillin/sulbactam, followed by oral amoxicillin/clavulanate upon discharge, with ongoing wound care follow-up. Although probiotics are generally considered safe, this case demonstrates that L. acidophilus can act as a pathogen in high-risk patients. Necrotizing infection due to L. acidophilus is exceptionally uncommon but should be recognized as possible, particularly in immunocompromised hosts."

Cardiovascular • Dermatology • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Septic Shock

Racial Disparities in Severe Cutaneous Adverse Reactions: A Report of Two Cases on Preventable Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Prescription Errors Through Medication Stewardship. (PubMed, Cureus) - "The first patient was a 28-year-old male with antibiotic-related SJS after receiving amoxicillin-clavulanate for fungal balanitis. The second patient was a 54-year-old male with allopurinol-induced TEN despite no history of gout or hyperuricemia. These cases underscore the importance of medication stewardship, careful medication reconciliation, and clear communication between patients and providers."

Journal • Gout • Inflammatory Arthritis • Rheumatology • Steven-Johnson Syndrome

Antimicrobial resistance of bacteria isolated in a resource-limited region: the experience of the North Kivu Provincial Reference Laboratory in the Democratic Republic of the Congo. (PubMed, Front Med (Lausanne)) - "In E. coli, resistance exceeded 60% to ampicillin, amoxicillin/clavulanate, and ciprofloxacin...pneumoniae showed uniform resistance to ampicillin and high resistance to cefuroxime, cefotaxime, gentamicin, and colistin...Recommended actions include participation in WHONET/GLASS program and antibiotic stewardship. In the interim, empiric strategies should favor nitrofurantoin for uncomplicated cystitis, judicious aminoglycoside use where appropriate, early culture, and prompt de-escalation, reserving carbapenems for severe ESBL-risk presentations."

Journal • Infectious Disease • Pneumonia

Distribution and antibiotic resistance of Gram-negative bacteria from blood cultures before and during the COVID-19 pandemic. (PubMed, J Infect Dev Ctries) - "K. pneumoniae remained the most frequently isolated bacterium in both periods, while A. baumannii showed a significant increase during the pandemic. The 2.6-fold increase in A. baumannii may have been caused by the increased use of broad-spectrum antibiotics during the pandemic. These findings reflect data from a single hospital and should be validated by further multicenter studies."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Gut check: antimicrobial stewardship opportunities in intra-abdominal infections. (PubMed, Antimicrob Steward Healthc Epidemiol) - "However, IAIs provide ASPs an opportunity to translate evidence into practice while also addressing empiric broad-spectrum antibiotic use and establishing relationships with surgical stakeholders. In this review, we analyze five areas of emerging evidence within this heterogeneous field that merit close attention from ASPs, including spontaneous bacterial peritonitis prophylaxis, antibiotic management of appendicitis and biliary tract infections, and optimal amoxicillin-clavulanate and metronidazole dosing."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Perioperative Antimicrobial Prophylaxis for Invasive Dental Procedures: A Systematic Review and Random-Effects Meta-Analysis of Randomized and Placebo-Controlled Studies. (PubMed, Cureus) - "Individual trials showed marked reductions in post-extraction bacteremia surrogates with chlorhexidine mouthwash prophylaxis and with intravenous amoxicillin-clavulanate in extraction settings, whereas in uncomplicated extractions among well-controlled type 2 diabetes, antibiotics did not reduce postoperative complications and were associated with greater analgesic consumption...In parallel, microbiological evidence indicates that single-dose prophylaxis can promote short-term ecological disturbance and selection of resistant oral flora. Future trials should standardize endpoints (distinguishing clinical infection/implant failure from surrogate bacteremia measures), stratify by baseline risk, and prioritize antimicrobial stewardship to identify the limited patient subsets most likely to benefit."

Journal • Retrospective data • Review • Diabetes • Infectious Disease • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus

Infectious mononucleosis with ampicillin rash and a positive rapid streptococcal antigen test: a case report. (PubMed, Fukushima J Med Sci) - "We report a 22-year-old woman with fever, sore throat, lymphadenopathy, and a generalized erythematous rash after a 7-day course of amoxicillin-clavulanate. Serology confirmed acute Epstein-Barr virus infection, and throat culture revealed only alpha-hemolytic streptococci. This case underscores the diagnostic overlap between IM and streptococcal pharyngitis, the need for caution in interpreting rapid antigen tests, and the importance of avoiding unnecessary antibiotics in suspected viral illness."

Journal • Epstein-Barr Virus Infections • Infectious Disease • Otorhinolaryngology

A Mysterious Case of Autoimmune Hepatitis Triggered by Herpes Zoster Virus Versus Drug-Induced Liver Injury. (PubMed, Cureus) - "While evaluating a patient with suspected autoimmune hepatitis, common causes such as viral hepatitis, Epstein-Barr virus, and medications like amoxicillin-clavulanic acid, statins, nitrofurantoin and methyldopa must be ruled out. She was observed with findings typical of cholestatic liver disease, and an extensive workup, including imaging and liver biopsy, was done to determine the cause of liver injury. Her clinical presentation, laboratory and Imaging findings favored Herpes Zoster virus as the likely culprit for autoimmune hepatitis."

Journal • Autoimmune Hepatitis • Cholestasis • CNS Disorders • Diabetes • Endocrine Disorders • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Hepatitis C • Hepatology • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Keratitis • Liver Failure • Metabolic Disorders • Neuralgia • Ocular Inflammation • Ophthalmology • Pain • Rheumatoid Arthritis • Rheumatology • Scleritis • Type 1 Diabetes Mellitus • Ulcerative Colitis • Uveitis • Varicella Zoster

Molecular pharmacodynamics of amoxicillin-clavulanic acid for urinary tract infections caused by Escherichia coli (ESCMID Global 2026) - No abstract available

PK/PD data • Infectious Disease • Nephrology

Development of a rapid actinomycetoma rapid in vitro susceptibility assay for determining the susceptibility towards amikacin, trimethoprim/sulfametoxazole and amoxicillin/clavulanic acid (AMAnTA) in actinomycetoma causative agents (ESCMID Global 2026) - No abstract available

Preclinical

Cessation of amoxicillin/clavulanate selective reporting and association with antibiotic prescribing and C. difficile infection in Ontario, 2017-2024: a natural experiment (ESCMID Global 2026) - No abstract available

Infectious Disease

Combined application of bacteriophages and amoxicillin/clavulanate in a dynamic bladder infection model to target uropathogenic Escherichia coli (ESCMID Global 2026) - No abstract available

Infectious Disease

Antimicrobial levels in hepatobiliary infections (ALIBI study): a prospective PK/PD study of amoxicillin/clavulanic acid and piperacillin/tazobactam in biliary fluid (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Hepatology • Infectious Disease

Deciphering the impact of age on amoxicillin/clavulanate disposition in older adults: a population pharmacokinetic analysis (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data

Impact of phenoxymethylpenicillin, amoxicillin and amoxicillin/clavulanic acidon the gut microbiome, resistome and mobilome: a randomised clinical trial with healthy adults (ESCMID Global 2026) - No abstract available

Clinical

A rare case of Streptomyces fradiae hand actinomycetoma. (PubMed, IDCases) - "A skin biopsy of the lesion confirmed the diagnosis of actinomycetoma, and the patient was treated with ceftriaxone IV for 14 days followed by oral amoxicillin clavulanic acid for a total of 3 months. The patient had significant clinical recovery with no recurrence of the infection. Streptomyces fradiae is a rare causative agent of actinomycetoma, and this case highlights the importance of early diagnosis and prolonged antibiotic therapy in the management of this infection."

Journal • Infectious Disease

Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae in Vietnam: a systematic review and meta-analysis. (PubMed, Lancet Reg Health West Pac) - "High non-susceptibility rates were observed for penicillin (64%), macrolides (70%-91%), sulfamethoxazole-trimethoprim (70%), tetracycline (84%), and several other antibiotics. Moderate to low non-susceptibility rates were observed for amoxicillin (22%), amoxicillin-clavulanate (6%), moxifloxacin (1%), vancomycin (1%), and rifampicin (0%)...Inclusion of PCV into the country's National Immunisation Program at the earliest opportunity will have a large impact on childhood disease. Gavi, the Vaccine Alliance, and Australia's Department of Foreign Affairs and Trade (DFAT) provided funding support for this project."

Journal • Retrospective data • Infectious Disease • Pneumococcal Infections • Pneumonia

Effect of Vonoprazan-Amoxicillin Combined with Compound Lactobacillus acidophilus on Symptoms and Gut Microbiome in Patients with Functional Constipation (ChiCTR) - P=N/A | N=136 | Not yet recruiting | Sponsor: The First Affiliated Hospital with Nanjing Medical University; The First Affiliated Hospital with Nanjing Medical University

New trial • Constipation • Gastroenterology • Gastrointestinal Disorder

Resistance of uropathogens to gepotidacin: a systematic review of in vitro antimicrobial susceptibility studies. (PubMed, Int J Antimicrob Agents) - "Gepotidacin has very good antimicrobial activity against a variety of pathogens that cause uUTIs. Importantly, it retains activity against uropathogen isolates that exhibit resistance to other antibiotics commonly used for UTIs making it a useful addition to a physician's therapeutic arsenal."

Journal • Preclinical • Review • Infectious Disease • Nephrology • Pneumonia

Antibacterial resistance in urinary samples from long term care-facility and community-dwelling older people in Gauteng, South Africa. (PubMed, J Glob Antimicrob Resist) - "LTCF residence was independently associated with higher AMR in several common urinary pathogens. These findings suggest that empirical UTI regimens commonly used in community-dwelling older adults may be inadequate for LTCF residents. Setting-specific antibiograms, improved diagnostic stewardship, and strengthened AMS interventions are needed to support appropriate prescribing. Further studies incorporating patient-level clinical factors are warranted to refine empirical treatment recommendations for older adults across care settings."

Journal • Infectious Disease • Nephrology