amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Multimodal diagnostic approach for identifying Actinomyces odontolyticus pneumonia: a case report and literature review. (PubMed, Front Med (Lausanne)) - "The patient exhibited marked clinical and radiological improvement following a period of amoxicillin/clavulanic acid therapy...We anticipate that these findings will enhance clinical awareness of PA, facilitating early detection, accurate diagnosis, and improved patient management. To our knowledge, this represents the first reported case of A. odontolyticus pneumonia diagnosed using a combined NGS and histopathology approach, as well as the largest case series published for this condition."

Journal • Cough • Infectious Disease • Pneumonia • Pulmonary Disease • Pyoderma Gangrenosum • Respiratory Diseases

Expanding the diagnostic spectrum of malignant otitis externa: a case report of proteus infection in a non-immunosuppressed patient. (PubMed, Front Med (Lausanne)) - "Empirical treatment with amoxicillin/clavulanic acid was ineffective. Culture identified Proteus mirabilis, resistant to multiple antibiotics but sensitive to piperacillin/tazobactam, which was administered with supportive care...It emphasizes the need to consider uncommon pathogens and atypical clinical profiles in MOE. Early diagnosis, microbiological confirmation, and tailored antimicrobial therapy were critical for favorable outcomes."

Journal • Infectious Disease • Metabolic Disorders • Otorhinolaryngology • Pain

A Rare Case of Parapharyngeal Abscess in a Healthy Adult: Importance of Timely Diagnosis and Intervention. (PubMed, Cureus) - "Treatment was initiated with clindamycin, intravenous dexamethasone, and Toradol for analgesic relief. Otolaryngology consultation suggested a transoral incision and drainage (I/D) under general anesthesia. A prophylactic seven-day course of oral Augmentin (amoxicillin-clavulanate) was prescribed at discharge. This case provides an excellent investigation into the importance of early intervention for rare bacterial infections of the head/neck region occurring in a patient population with no relevant risk factors."

Journal • Anesthesia • Cardiovascular • Dermatology • Hematological Disorders • Infectious Disease • Otorhinolaryngology • Pain • Pulmonary Disease • Septic Shock • Thrombosis

Efficacy of meglumine antimoniate treatment on boxer Leishmania infantum skin lesions: case report. (PubMed, Front Vet Sci) - "The dog underwent a therapeutic protocol consisting of miltefosine (Milteforan™ - Virbac®) (2 mg/Kg b.w. per os) for 28 days and allopurinol 300 mg (10 mg/Kg b.w. po) for 6 months...The subsequent antibiotic and anti-inflammatory therapy based on amoxicillin+clavulanic acid (12.5 mg/kg b.w. po for 15 days), metronidazole (75000UI + 12.5 mg po for 15 days), and prednisone (0.5 mg/kg b.w. po for 10 days) failed to be effective; thus, the lesion worsened and also spread to the dorsal femoral surface of both hind limbs, presenting as blackish, swollen, painful, alopecic and oozing bloody and purulent material...Interestingly, the experimental localized treatment with Glucantime® proved to be crucial in counteracting Leishmania skin lesions. The results obtained suggest that, through an appropriate diagnosis, it is possible to define targeted and effective therapeutic protocols useful in the management of canine leishmaniasis."

Journal • Dermatology • Infectious Disease • Pain

Trimethoprim/sulfamethoxazole and risk of haemophagocytic lymphohistiocytosis (HLH): a literature review and disproportionality analysis using individual case safety reports from FAERS. (PubMed, J Antimicrob Chemother) - "Trimethoprim/sulfamethoxazole may be linked to an increased risk of HLH. Further pharmacoepidemiologic research is necessary to confirm these findings and inform the safe clinical use of trimethoprim/sulfamethoxazole."

Journal • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Nephrology • Rare Diseases

National survey on aspiration pneumonia in elderly hospitalized or institutionalized patients in France in 2023. (PubMed, Infect Dis Now) - "This survey shows consensus regarding diagnostic criteria and antibiotic therapy. However, the significant variation in prevention and nutritional management across specialties and practice settings highlights the need for specific recommendations."

Journal • Infectious Disease • Otorhinolaryngology • Pneumonia • Respiratory Diseases

Molecular characterization of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from Sonali chicken meat in Bangladesh. (PubMed, Sci Rep) - "Antimicrobial susceptibility testing by disc diffusion method revealed complete resistance to ampicillin (100%), with high resistance to erythromycin (87.59%) and third-generation cephalosporins. Furthermore, the lowest resistance was observed for amoxicillin-clavulanate (3.01%)...Significant positive correlations were observed among β-lactamase genes, highlighting the complexity of resistance mechanisms. Our results demonstrate the necessity of judiciously using antibiotics in Sonali chickens to prevent the emergence of resistant bacterial strains."

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NOSES: Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis (clinicaltrials.gov) - P4 | N=3720 | Recruiting | Sponsor: Daniel Merenstein | Active, not recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Endoscopic-guided cultures in pediatric recurrent acute rhinosinusitis. (PubMed, Int J Pediatr Otorhinolaryngol) - "In PRARS, endoscopic-guided middle meatal cultures provided an accurate identification of the causative organism. A culture directed antibiotic choice will lead to a more favorable medical outcome."

Journal • Anesthesia • Infectious Disease • Influenza • Novel Coronavirus Disease • Otorhinolaryngology • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Sinusitis

Antibiotic susceptibility patterns of Salmonella isolates from clinical, food, and environmental sources in Addis Ababa and surrounding towns, Ethiopia. (PubMed, Microbiol Spectr) - "Resistance to trimethoprim-sulfamethoxazole and chloramphenicol was noted in 24.6% and 19.7% of isolates, respectively. Azithromycin resistance was also sensible at 27.9%. In contrast, ciprofloxacin showed relatively low resistance at 8.2%...Gentamicin (3.3%), ceftriaxone (6.6%), and amoxicillin-clavulanic acid (9.8%) remained largely effective, showing low resistance rates...High antimicrobial resistance, especially to ampicillin and tetracycline, highlights the urgent need for improved surveillance, rational antibiotic use, and infection control...This study provides a comprehensive analysis of Salmonella isolates from clinical, food, and environmental samples in Addis Ababa and nearby towns, offering current data on antimicrobial resistance patterns. By using updated laboratory standards and sampling diverse sources, the findings highlight the urgent need for improved food safety practices, sanitation, and antimicrobial stewardship."

Journal • Infectious Disease

Characterization of bla NDM-5-carrying plasmids in two clinical Salmonella isolates from Jiaxing city, China. (PubMed, Front Microbiol) - "Both isolates were multidrug resistant, with insusceptibility to ampicillin, ampicillin/sulbactam, amoxicillin/clavulanic acid, cefuroxime, ceftiofur, cefazolin, cefoxitin, cefotaxime, ceftazidime, cefepime, ceftazidime/avibactam, meropenem, imipenem, ertapenem, tetracycline, gentamicin, trimethoprim/sulfamethoxazole, florfenicol, chloramphenicol, ciprofloxacin, colistin, and polymixin B. The bla NDM-5-carrying plasmids in 2023JX045 and 2024-406 were named p23045-NDM5 and p2024406-NDM5, respectively, with both belonging to the incompatibility (Inc)HI2/IncHI2A group and sequence type ST3. IS26-flanked composite transposons appeared to play an important role in the formation of this region. The dissemination of blaNDM in Salmonella isolates and the complexity of the bla NDM-5 region highlight the urgent need to monitor carbapenem-resistant S. enterica."

Journal • Infectious Disease

Isolation, Identification, and Antibiogram Characteristics of Staphylococcus aureus From Dairy Cows Kept Under Extensive Management System, in the Uba DebreTsehay District of Southern Ethiopia. (PubMed, Vet Med Sci) - "aureus isolates showed no susceptibility (0%) to penicillin G or tetracycline, but exhibited 100% susceptibility to amoxicillin-clavulanate, cefoxitin, ciprofloxacin, chloramphenicol, oxacillin, trimethoprim-sulphamethoxazole, and gentamicin. Mastitis is a severe problem for dairy production in the study area, and the resistance of S. aureus to commonly used antibiotics was observed. Therefore, proactive management strategies including adequate sanitation of the dairy environment, regular screening of animals, and rational use of antibiotic agents were recommended to maintain the productivity and well-being of dairy cows in the study areas."

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RESPIRATORY-ASSOCIATED DISEASE IN SNOW LEOPARDS (PANTHERA UNCIA) IN A NORTH AMERICAN ZOOLOGICAL INSTITUTION: 1997-2022. (PubMed, J Zoo Wildl Med) - "Coinfections were common (91%, 21/23), with only two cases identifying a single agent. Antibiogram results suggest that aminoglycosides, tetracyclines, trimethoprim-sulfa, enrofloxacin, and amoxicillin-clavulanic acid were the most effective antibiotic choices for the identified respiratory pathogens."

Journal • Pulmonary Disease • Respiratory Diseases

Evaluating Dog Bite-Induced Facial Trauma: A Study from a Single Tertiary Care Center (AAO-HNSF 2025) - "There were 878 patients prescribed intravenous or oral antibiotics (96.9%), and amoxicillin-clavulanate was the most frequently prescribed (61.2%)... Dog bites to the head and neck are a common injury. Many cases require hospital admission and bedside or operative repair. Understanding the demographics of dog bites to the head and neck is important in order to understand the physical and socioeconomic burden of disease, identify gaps in adherence to protocols and guidelines, and identify areas of targeted education and preventative interventions."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Genetic Disorders • Infectious Disease • Psychiatry • Tetanus

Repeat Antibiotic Usage and Antibiotic Associated Complications in Chronic Rhinosinusitis (AAO-HNSF 2025) - "Amoxicillin-clavulanate was the most prescribed repeat antibiotic (23.98%) followed by levofloxacin (12.87%) and doxycycline (12.03%). Although antibiotic usage for CRS has decreased recently, the substantial utilization of first-line and repeat antibiotics may contribute to complications such as antibiotic allergy."

Immunology • Infectious Disease • Inflammation • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Prevalence of Shiga toxin-producing Escherichia Coli O157 in Moroccan food and antimicrobial resistance profiles of the strains isolated. (PubMed, World J Microbiol Biotechnol) - "All isolates were resistant to amoxicillin/clavulanic acid, 11/14 (78.6%) were resistant to streptomycin, 10/14 (71.4%) were resistant to tobramycin, 9/14 (64.3%) were resistant to ertapenem and piperacillin, 8/14 (57.1%) were resistant to cefotaxime and 7/14 (50.0%) were resistant to ampicillin and ceftazidime. All isolates were sensitive to amikacin, ceftazidime/avibactam, gentamicin, imipenem, nitrofurantoin and trimethoprim/sulfamethoxazole. Results indicate food producers and sellers may need further training in good hygiene rules, highlighting the importance of implementing strict quality control to ensure food safety."

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Sociodemographic and clinical factors influencing typhoid fever prevalence and multidrug resistance in Niger State, Nigeria. (PubMed, PLoS One) - "Among the 624 participants, typhoid fever prevalence was recorded at 36.5%, with young adults (ages 18-27) and semi-urban residents demonstrating higher infection rates. Antibiotic sensitivity testing revealed 98% resistance to amoxicillin/clavulanic acid, whereas gentamicin and levofloxacin exhibited high efficacy. Our findings underscore the urgent need for health education, improved antibiotic regulation, and Water, Sanitation, and Hygiene (WASH) interventions to control typhoid fever and mitigate MDR challenges."

Journal • Infectious Disease

Bacteria species and antibiotic resistance in bovine mastitis within the framework of the «ReLait» project (PubMed, Schweiz Arch Tierheilkd) - "Increased antimicrobial resistance to aminopenicillins (90,3 %) and amoxicillin/clavulanic acid (20,8 %) was found among coliform bacteria...To counteract this, the use of antibiotics for the treatment of subclinical or clinical mastitis should be reconsidered. Bacterial milk culture is always indicated to ensure specific bacterial treatment with or without antibiotics."

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An Atypical Manifestation of Cellulitis Induced by Proteus mirabilis. (PubMed, Cureus) - "Treatment was adjusted to amoxicillin-clavulanate, but persistent inflammation required a second course of antibiotics due to the patient's sulfa allergy...Tailoring antibiotics based on culture results is essential to achieving resolution and avoiding complications. A broad diagnostic approach can be valuable in managing unusual or resistant infections."

Journal • Allergy • Cardiovascular • Dermatology • Immunology • Infectious Disease • Inflammation • Nephrology

Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Trial (clinicaltrials.gov) - P=N/A | N=366 | Not yet recruiting | Sponsor: Universitat Jaume I

New trial • CNS Disorders • Depression • Hepatology • Major Depressive Disorder • Mood Disorders • Psychiatry

PEN-FAST in pediatrics: a reliable tool for penicillin allergy assessment? (PubMed, Eur J Pediatr) - "In outpatient settings, PEN-FAST may facilitate the rapid identification of low-risk patients and aid in the planning of diagnostic testing. New validated point-of-care clinical tools are needed to identify low-risk penicillin allergies in children, and further validation of PEN-FAST is required in larger international cohorts."

Journal • Retrospective data • Allergy • Immunology • Pediatrics

Synergistic antimicrobial and probiotic activity of lactic acid bacteria isolated from Tarkhineh against Candida albicans. (PubMed, Sci Rep) - "However, strains of Ta19 and Ta51 demonstrated higher susceptibility to nine common antibiotics (cefixime, azithromycin, amoxicillin, doxycycline, sulfamethoxazole, ciprofloxacin, cephalexin, amoxicillin-clavulanic acid, and vancomycin), as evidenced by susceptibility spectrum ranging from 12.00 to 39.67 mm...plantarum PTCC 1745) and antibiotic (fluconazole)...In conclusion, a new bacterial extract formulation containing 25% L. plantarum subsp. plantarum Ta19 and 75% L. mesenteroides Ta51 has potential as a powerful probiotic against Candida."

Journal • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • CAT

A case of post-traumatic orbital cellulitis caused by Eikenella corrodens. (PubMed, BMC Ophthalmol) - "This report details a unique case of orbital cellulitis due to Eikenella corrodens infection. The treatment strategy, combining targeted antibiotics with ultrasound-guided abscess management, proved effective."

Journal • Dermatology • Infectious Disease • Ocular Infections • Ocular Inflammation • Pain

Clival osteomyelitis as a rare complication of paediatric melioidosis. (PubMed, BMJ Case Rep) - "The patient initially received intravenous ceftazidime and oral trimethoprim-sulfamethoxazole (TMP-SMX). However, she developed hypersensitivity reactions to TMP-SMX, requiring a switch to oral amoxicillin-clavulanate. She responded well with complete resolution of the submandibular and parotid abscesses after 4 weeks of treatment. This case emphasises the importance of a high index of suspicion of melioidosis in endemic regions due to its diverse clinical presentation and diagnostic challenges."

Journal • Immunology • Infectious Disease • Inflammation • Pediatrics

Resistance Profiling of Predominant Non-E. coli Enterobacteriaceae Isolated From Humans, Food Animals, and the Environment in the Fako Division of Cameroon. (PubMed, Biomed Res Int) - "The quinolones (norfloxacin, 94.7%, and ofloxacin, 91.2%), carbapenem (imipenem, 96%), aminoglycoside (amikacin, 95.5%), and chloramphenicol (91.3%) were the most active drugs. Penicillins (amoxicillin, 24.7%; ampicillin, 21.2%; and amoxicillin-clavulanic acid, 19.9%) were the most inactive drugs. However, isolates showed the highest rate of intermediate susceptibility (48.6%) to cefepime...Five (17.9%) isolates out of the 28 screened for PMQR and beta-lactamase genes were positive for both sets of genes. Resistance to antibiotics was high with strains of the different genera carrying PMQR and beta-lactamase resistance genes circulating in humans, food animals, and the environment in the Fako Division of Cameroon."

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