amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Efficacy and Safety of Oral Cloxacillin Versus Amoxicillin-Clavulanic Acid in Treating Pediatric Acute Bacterial Lymphadenitis. (PubMed, Cureus) - "This finding suggests the non-inferiority of cloxacillin in comparison with amoxicillin-clavulanic acid. Conclusion Oral cloxacillin is as effective and safe as compared to amoxicillin-clavulanic acid in uncomplicated pediatric bacterial lymphadenitis."

Journal • Pediatrics • CRP

Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation? (PubMed, BMC Microbiol) - "This study showed no correlation between the resistance profiles of the clinical and effluent isolates. The relationship between AMR in hospital effluent and clinical resistance may depend on the antimicrobial agents and bacterial species studied."

Journal • Infectious Disease • Pneumonia

THE CARBON COST OF INAPPROPRIATE ANTIBIOTIC PRESCRIPTIONS IN PAEDIATRIC EMERGENCY CARE: A MULTICENTER OBSERVATIONAL STUDY (ESPID 2025) - "In total, 12,386 antibiotics were prescribed to these children, most commonly amoxicillin (n= 3,144, 25.4%), amoxicillin/ clavulanate (n=2,322, 18.7%), and penicillin (n=1,900, 15.3%)...Conclusions/Learning Points Targeted antibiotic prescribing results in better clinical care and reduces antibiotic resistance, but also has a significant impact on carbon footprint. Interventions for optimizing antibiotic prescriptions can lead to a significant reduction in CO2 emission as a secondary outcome."

Clinical • Observational data • Infectious Disease

CLINICAL PRACTICE INDICATORS IN INFECTION PREVENTION/CONTROL AND ANTIMICROBIAL STEWARDSHIP IN THE PEDIATRIC POPULATION BEFORE AND AFTER THE PARTICIPATION IN THE PILOT PHASE OF AN ONLINE EDUCATIONAL PROJECT (TEAM-COACH PROJECT) (ESPID 2025) - "Clinical practices were assessed the month before the training and one and three months after, and included: volume of hydro-alcoholic solution requested per unit/patient-day or visit, the proportion of patients receiving antibiotics/total admitted patients or visits, and ampicillin/cefotaxime-ceftriaxone ratio (hospitalized) or amoxicillin/amoxicillin-clavulanate ratio (outpatient). This initiative holds promise as a foundation for multilingual IPC-AMS training. Co-funded by the European Union (GA:101079939)."

Clinical • Infectious Disease

Frequency and antimicrobial susceptibility profiles of bacterial species isolated from canine and feline urine samples in Sydney, Australia, 2012-2021. (PubMed, Vet Microbiol) - "Susceptibility of S. pseudintermedius to amoxicillin-clavulanic acid and oxacillin decreased from 100 % in 2012 to 54 % in 2021.Twenty-two percent of S. pseudintermedius isolates were methicillin-resistant. Compared to reports from other locations, our findings suggest that amoxicillin may be less effective as a first-line choice for treating canine and feline UTI in Sydney."

Journal • Infectious Disease • Nephrology

Association between hospitalised childhood pneumonia and follow-up chest radiographs in high-risk populations: a secondary analysis of a multicentre randomised controlled trial. (PubMed, Arch Dis Child) - "In high-risk settings, younger age, those with previous pneumonia hospitalisation, or ongoing respiratory symptoms/signs 4 weeks post-discharge from hospitalised CAP may be associated with incomplete CXR resolution. Consequently, follow-up imaging and monitoring may be warranted in these children."

Journal • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Disease • Respiratory Diseases

Prevalence of Salmonella enterica serotypes isolated from broiler liver and their antibiotic resistance profiles. (PubMed, J Food Prot) - "The Salmonella isolates (n=38) were resistant to cefepime (60.5%), chloramphenicol (57.9%), trimethoprim-sulfamethoxazole (50.0%), amoxicillin-clavulanic acid (39.5%), azithromycin (28.9%), ofloxacin (26.3%), and cefoxitin (13.2%). Multidrug-resistance (MDR) accounted for 47.4% of Salmonella isolates. MDR was observed in S. Infantis (17/31, 54.8%) and S. Agona (1/2, 50.0%), nevertheless not in S. Enteritidis."

Journal

Vonoprazan-based therapy versus standard regimen for Helicobacter pylori infection management in Egypt: an open-label randomized controlled trial. (PubMed, Sci Rep) - P4 | "The study evaluates the efficacy, safety, and compliance of vonoprazan dual and triple therapy (VDT and VTT) both consisting of vonoprazan 20 mg twice daily and amoxicillin/clavulanate 875 mg/125 three times daily plus clarithromycin 500 mg twice daily added in VTT versus standard triple therapy (STT), in which vonoprazan 20 mg in VTT is replaced by PPI standard or double dose all for 14 days, along with investigating factors influencing compliance, treatment response, and symptoms severity. Gender, frequency of COVID-19 vaccination, height, and BMI were the only factors assessed influencing infection symptoms severity. ClinicalTrial.gov ID identifier: NCT05614934, first posted date (07/11/2022)."

Journal • Infectious Disease • Novel Coronavirus Disease

Comparison of Disc Diffusion and Sensititre® Broth Microdilution Methods for Antimicrobial Susceptibility Testing of Bacteroides fragilis Group clinical isolates following the French Guidelines. (PubMed, Anaerobe) - "DDT and Sensititre® Broth Microdilution demonstrated strong concordance for most antibiotics. Predictive values estimated using Bayesian model showed that Sensititre® offered the highest overall Se and Sp."

Journal

RISK FACTORS, CLINICAL PRESENTATIONS, AND TREATMENT OUTCOMES IN PATIENTS WITH SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) AND SIBO WITH INTESTINAL METHANOGEN OVERGROWTH (IMO): A 10-YEAR RETROSPECTIVE STUDY (DDW 2025) - "All patients received fluoroquinolone, amoxicillin-clavulanate, or metronidazole for 10–14 days...Conclusion : SIBO and SIBO with IMO share similar demographic and clinical features, with notable differences in abdominal radiation exposure and abdominal pain. However, treatment response did not differ significantly, suggesting that identifying IMO in SIBO patients may have limited clinical meaningfulness."

Retrospective data • Constipation • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Pain • Scleroderma • Systemic Sclerosis

EFFICACY OF PHARMACOLOGICAL TREATMENT IN PEDIATRIC INTESTINAL PSEUDO-OBSTRUCTION (DDW 2025) - "We identified the first instance each patient was treated with erythromycin, amoxicillin/clavulanic acid, prucalopride, pyridostigmine, or octreotide and recorded symptoms before and 1 month after starting the medication. Response to prokinetic medications was variable in our cohort of children with PIPO. While less than half improved with erythromycin, over half had some degree of improvement with prokinetics with a more generalized effect like prucalopride, pyridostigmine, and octreotide. Prospective studies are needed to further investigate this potential difference in prokinetic efficacy."

Clinical • Constipation • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics

Kounis Syndrome after Oral Amoxicillin Clavulanate. (PubMed, Int J Appl Basic Med Res) - "Electrocardiogram (ECG) showed ST segment changes along with elevated troponin I. Suspecting Kounis syndrome, she was administered pheniramine maleate, hydrocortisone, and oral antiplatelets along with intravenous fluids. She recovered completely and was discharged after 48 h. This case highlights coronary vasospasm during an ongoing allergic reaction and its management with antihistamines, steroids, and antiplatelet drugs. Nebulized adrenaline was safely given with ECG monitoring for airway edema."

Journal • Allergy • Cardiovascular • Hematological Disorders • Immunology • Thrombosis

Parotid Lithiasis Revealing Previously Undiagnosed Diabetes Mellitus: A Case Report (ESPE-ESE 2025) - "The patient was admitted in our department and started on Amoxicillin-clavulanic acid...ConclusionThis observation underlines the importance of looking for diabetes mellitus in patients with lithiasic parotiditis, particularly when associated risk factors are present. Early recognition of diabetes allows for timely intervention and prevention of long-term complications."

Case report • Clinical • CNS Disorders • Diabetes • Endocrine Disorders • Metabolic Disorders • Otorhinolaryngology • Type 1 Diabetes Mellitus

DIAGNOSIS AND THERAPEUTIC MANAGEMENT OF INFECTED DIABETIC FOOT: INSIGHTS FROM 278 CASES (ESPE-ESE 2025) - "Third-generation cephalosporins were the most prescribed antibiotics (91%), followed by ciprofloxacin (77%), metronidazole (66.9%), and amoxicillin-clavulanic acid in 8.2%. This study highlights the complexity of managing diabetic foot infections. It underscores the importance of a multidisciplinary approach combining local care, rigorous medical follow-up, and tailored patient education."

Clinical • Diabetes • Infectious Disease • Metabolic Disorders • Type 2 Diabetes Mellitus

Kimura disease: A rare case affecting the inguinal lymph node. (PubMed, Int J Surg Case Rep) - "This case underscores the need for awareness of atypical presentations of Kimura disease. Early recognition and appropriate management can prevent unnecessary interventions and misdiagnosis. Surgical excision combined with corticosteroid therapy was effective, leading to an uneventful recovery."

Journal • Cardiovascular • Coronary Artery Disease • Heart Failure • Hypertension • Immunology • Infectious Disease • Mood Disorders • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Escherichia coli in septic arthritis: prevalence and antibiotics susceptibility patterns. (PubMed, Iran J Microbiol) - "The identified E. coli strain showed significant resistance to common antibiotics: amoxicillin, amoxicillin-clavulanate, ceftriaxone, sulfamethoxazole/trimethoprim, gentamicin, tetracycline, and erythromycin. Antibiotic resistance in E. coli from SA patients suggests the need for accurate antibiotic selection to ensure prompt treatment."

Journal • Hematological Disorders • Immunology • Orthopedics • Rheumatology • CRP

Exploring of spectroscopic, dielectric, and bioactivity performance of bioglass/sodium alginate-PVP loaded-Amoxicillin/Clavulanic Acid microspheres for bone tissue engineering. (PubMed, Sci Rep) - "Furthermore, antimicrobial results of BIOGLASS/SA-PVP/Amoxicillin/Clavulanic Acid microspheres reveal a notable impact on the antimicrobial performance. The in-vitro tests established that fabricated bio-microspheres are a promising opportunity for bone tissue engineering (substitutes and regeneration), signifying their promise for bone application."

Journal

Q Fever Pneumonia: Cross-reactivity and Diagnostic Complexity (ATS 2025) - "He had received two outpatient courses of antibiotics (amoxicillin and amoxicillin/clavulanate) and a short prednisone course without improvement...Empiric treatment was initiated with piperacillin-tazobactam and vancomycin, with the later addition of doxycycline for atypical coverage...Given severity of pneumonia and systemic involvement, he was started on planned 12-18 months of doxycycline and hydroxychloroquine...Additionally, cross-reactivity among autoimmune and infectious markers can result in false positives, further complicating the diagnostic process. A detailed exposure history and serologic testing are essential for timely diagnosis and treatment."

Cardiovascular • Cough • Crohn's disease • Dermatology • Fatigue • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Liver Failure • Musculoskeletal Pain • Nephrology • Nicotine Addiction • Pain • Pneumonia • Renal Disease • Respiratory Diseases • Vasculitis

No Cap! Recurrent Pneumonia in a Young Immunocompetent Adult (ATS 2025) - "The patient transitioned to amoxicillin-clavulanic acid and completed 6 weeks of total antibiotic therapy...The diagnosis and treatment of FΒA is dependent upon visualization of the foreign body with brοոϲhοѕϲοpy. In this case, the patient's history of recurrent pneumonia and subtle CT findings highlight the necessity of maintaining a high index of suspicion for FBA, even when initial patient history does not suggest it."

Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Cough • Infectious Disease • Pain • Pneumonia • Respiratory Diseases

Intraoperative Discovery of Nephrobronchial Fistula (ATS 2025) - "Case Descriptoin: A 52 year old woman who had completed a course of ciprofloxacin for cystitis two weeks prior presented to the hospital for three days of left flank pain, nausea, and dizziness...She remained on a prolonged course of amoxicillin-clavulanate after surgical intervention and was discharged home without further pulmonary complication...In these patients, there is risk for fistula formation to pararenal structures, including the lung. Early recognition of bronchial fistulization can prevent pulmonary complications and ensure the patient has involvement by appropriate care teams."

Infectious Disease • Inflammation • Nephrology • Pain • Renal Calculi • Urology

A Case of Unilateral Pulmonary Edema (ATS 2025) - "Intravenous clavulanate/amoxicillin and oral clarithromycin were commenced to treat a possible pneumonia. (C) TOE demonstrating severe MR jet. (D) Post-operative CXR demonstrating prosthetic mitral valve and resolved right-sided opacity."

Clinical • Cardiovascular • Cough • Infectious Disease • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • CRP

Dude, Where's My Dentures? Aspiration of Partial Dentures Leading to Post-obstructive Pneumonia (ATS 2025) - "He was discharged home with a seven-day course of amoxicillin-clavulanate for his post-obstructive pneumonia...While attempting to use a bronchial blocker to pull the dentures into the tube, we noted that the dentures were wedged at the end of the ET tube with insignificant changes to peak pressures or gas exchange. We were able to remove the dentures easily."

Infectious Disease • Pain • Pneumonia

Walking Into the Diagnosis: Severe Mycoplasma Pneumonia Complicating Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) (ATS 2025) - "He was diagnosed with community-acquired pneumonia (CAP), was admitted to the hospital, and received ceftriaxone and azithromycin. He was discharged 2 days later with a prescription for amoxicillin/clavulanic acid to complete an outpatient course...He was started on linezolid, piperacillin-tazobactam, and azithromycin...The patient was also started on steroids and rituximab... This case exemplifies a multifactorial presentation involving CLL with secondary infection and autoimmune complications. This highlights the importance of a thorough workup in cases of unresolving pneumonia and persistent leukocytosis to identify underlying hematologic conditions and atypical pathogens."

Anemia • Autoimmune Hemolytic Anemia • Chronic Lymphocytic Leukemia • Complement-mediated Rare Disorders • Cough • Genito-urinary Cancer • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Influenza • Leukemia • Novel Coronavirus Disease • Oncology • Pneumonia • Renal Cell Carcinoma • Respiratory Diseases • Respiratory Syncytial Virus Infections • Solid Tumor

Abdominal Pain in an Immunocompromised Lung Transplant Recipient Leading to Pneumaturia (ATS 2025) - "His immunosuppressive regimen consisted of mycophenolic acid, prednisone, and tacrolimus, along with prophylactic acyclovir/letermovir, bactrim, and itraconazole...He was empirically treated with piperacillin and tazobactam, which was transitioned to amoxicillin/clavulanate on discharge...Broad spectrum antibiotics alone are often insufficient. Our patient recognized pneumaturia quickly, leading to a timely intervention with a good outcome."

Clinical • Gastrointestinal Disorder • Hematological Disorders • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Leukopenia • Pain • Pulmonary Disease • Respiratory Diseases • Septic Shock • Transplantation • Urology

What Is in That Airway (ATS 2025) - "Chest X-ray revealed right lower lobe pneumonia for which he received Amoxicillin-Clavulanate for 10 days and azithromycin for 5 days...The patient was discharged on Levofloxacin with pulmonary clinic follow-up...Broncholiths are generally found by imaging and confirmed with bronchoscopy. Asymptomatic patients can be observed while symptomatic patients will usually undergo bronchoscopic or surgical removal."

Back Pain • Cardiovascular • Cough • Diabetes • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Musculoskeletal Pain • Oncology • Pain • Pneumonia • Respiratory Diseases • Tuberculosis • Type 2 Diabetes Mellitus