amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Fulminant Macrolide-Resistant Mycoplasma pneumoniae Pneumonia in a Young Adult: A Case Report. (PubMed, Cureus) - "Despite repeated negative rapid antigen tests for M. pneumoniae, the patient was suspected of having MRMP pneumonia based on the Japanese Respiratory Society (JRS) scoring system and bilateral pneumonia resistant to amoxicillin/clavulanate and azithromycin, which led to the administration of levofloxacin infusion. Hydrocortisone was administered as treatment for severe CAP...The diagnosis and treatment strategy resulted in early improvement. This case highlights the diagnostic approach for MRMP and the clinical course of severe ARDS associated with MRMP."

Journal • Acute Respiratory Distress Syndrome • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Thyroid Abscess Following Influenza Infection (ATA 2025) - "She was treated with intravenous ampicillin/sulbactam which was transitioned to oral amoxicillin/clavulanate, to complete a 10 day course of antibiotics. A potential risk factor for her thyroid abscess was impaired immune function given the recent infection. Our case highlights the importance of early diagnosis and management of acute thyroiditis and the consideration of abscess formation in healthy individuals during transient, immunocompromised states."

Diabetes • Endocrine Disorders • Human Immunodeficiency Virus • Infectious Disease • Influenza • Metabolic Disorders • Otorhinolaryngology • Respiratory Diseases

Recurrent breast abscess caused by Lawsonella clevelandensis: A case report and literature review. (PubMed, Medicine (Baltimore)) - "The clinical manifestations of Lawsonella clevelandensis infection are similar to those of other acid-fast bacilli (e.g., Nocardia and Mycobacterium tuberculosis), potentially leading to misdiagnosis and mistreatment, thereby delaying resolution of the condition. The methods used for treating infections by bacterial pathogens differ significantly, as do the prognoses, indicating the importance of precise diagnosis. Lawsonella clevelandensis should be included in the differential diagnosis of infections caused by acid-fast bacteria. Due to the extreme difficulty in culturing this bacterium in vitro, gene sequencing is used primarily for diagnosis. Overall, the prognosis of patients with Lawsonella clevelandensis infection is good. Timely debridement and drainage, combined with antibiotic treatment, can usually lead to a cure."

Journal • Review • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CAT • IFNG

Tender Nodules On Palms After Amoxicillin-Clavulanate And Ciprofloxacin Treatment (EADV 2025) - No abstract available

False equivalence: differences in the in vitro activity of ampicillin-sulbactam and amoxicillin-clavulanate in several Enterobacterales species. (PubMed, JAC Antimicrob Resist) - "Isolates of E. coli, K. pneumoniae group and P. mirabilis with susceptibility profiles consistent with ESBL production (ceftriaxone resistant and cefoxitin susceptible) were more likely to be susceptible to AMC but not susceptible to SAM than isolates without this susceptibility phenotype (E. coli, 38% versus 27%, P < 0.0001; K. pneumoniae group: 40% versus 10%, P < 0.0001; P. mirabilis: 24% versus 6%, P < 0.0001). The high prevalence of SAM-not susceptible, AMC-susceptible isolates supports reporting AST results for both SAM and AMC to maximize options for antimicrobial therapy and to support antimicrobial stewardship."

Journal • Preclinical • Infectious Disease • Pneumonia

Prevalence, characterization, and transmissible factors of foodborne pathogens in the Al-Qassim Region, Saudi Arabia. (PubMed, Cell Mol Biol (Noisy-le-grand)) - "coli isolates exhibited complete resistance (100%) to ampicillin, amoxicillin-clavulanic acid, cefoxitin, and cephalothin. High resistance rates were also observed for norfloxacin (80.8%) and tetracycline (73.1%)...Imipenem remained the most effective antibiotic, showing 100% susceptibility among E. coli and S. aureus isolates and 93.3% effectiveness against A. baumannii. These findings underscore the critical need for routine microbial surveillance, implementation of rapid diagnostic tools, and enforcement of stringent food safety regulations to curb the spread of antimicrobial-resistant pathogens through the food supply chain."

Journal

Melioidosis presenting as septic arthritis in hip joint of a 60-year old patient: Findings from a hospital-based surveillance in Bangladesh. (PubMed, J Infect Public Health) - "pseudomallei was isolated from blood culture and it was sensitive to meropenem, amoxicillin-clavulanic acid, cotrimoxazole, ceftazidime and doxycycline. The findings of the case report are valuable for raising clinical suspicion and prompting laboratory testing to detect melioidosis. The report also detailed the disease progression and the response to antibiotic therapy."

Journal • Immunology • Infectious Disease • Musculoskeletal Pain • Pain • Pneumonia • Respiratory Diseases • Rheumatology

DILI Is an Important Cause of Hepatocellular and Mixed Liver Injury-A Nationwide Prospective Study on Elevated Liver Enzymes. (PubMed, Liver Int) - "The most common cause in both groups was choledocholithiasis. IH was associated with hepatocellular injury whereas HBC was associated with cholestatic injury. DILI was an important aetiology with 8% prevalence in the cohort and was similar in the two groups."

Journal • Biliary Cancer • Hepatology • Infectious Disease • Inflammation • Liver Failure • Oncology • Solid Tumor • Transplantation

PO-llution control: a cross-sectional study on the role of antimicrobial stewardship in reducing healthcare's carbon footprint. (PubMed, JAC Antimicrob Resist) - "Piperacillin-tazobactam, amoxicillin-clavulanic acid, cefuroxime, metronidazole and meropenem together accounted for over 84% of total emissions, with piperacillin-tazobactam alone contributing 97.5 kg CO₂e and 41.6 kg of waste from 62 prolonged prescriptions. In addition to patient safety risks, prolonged IV antimicrobial courses generate considerable environmental waste. Aligning AMS with sustainability goals may contribute to addressing the dual crises of antimicrobial resistance and climate change."

Journal • Observational data

An antibiotic stewardship initiative focused on community-acquired bacterial pneumonia (CABP) in outpatient clinics and urgent care centers: a 2023-2024 community health system experience. (PubMed, Antimicrob Steward Healthc Epidemiol) - "Among patients with comorbidities, combination antibiotics increased by 12% post-intervention, driven by concordant prescriptions including amoxicillin/clavulanate plus azithromycin while the most frequently prescribed discordant combination was amoxicillin plus azithromycin. A stewardship intervention, including an order-set and awareness campaign improved the selection of combination therapy for appropriate patients but did not improve overall guideline concordance. For health systems without a dedicated outpatient ASP, these data will help bolster stewardship efforts towards more effective strategies."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Oncology • Pneumonia • Renal Disease • Respiratory Diseases

A Cross-Sectional Study of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated From Clinical Samples: Single-Center Investigation in Indonesia. (PubMed, Int J Microbiol) - "ESBL-producing E. coli isolates demonstrated high sensitivity (above 90%) to amoxicillin-clavulanic acid, ceftazidime, ertapenem, meropenem, and tigecycline. The results highlight the urgent need for enhanced surveillance and infection control measures in healthcare settings to combat the spread of ESBL-producing E. coli. Healthcare professionals, including nurses and clinicians, must be aware of this resistance pattern to guide empirical treatment choices and improve patient outcomes in managing infections caused by these resistant strains."

Journal • Observational data • Infectious Disease

Amoxicillin-Clavulanic Acid-Induced Rash in Epstein-Barr Virus Infection: A Case Report of a Diagnostic Pitfall in a 24-Year-Old Male. (PubMed, Cureus) - "This case underscores the critical need for careful differential diagnosis between viral and bacterial tonsillitis. It demonstrates that an amoxicillin-clavulanic acid-induced rash can serve as an important clue for underlying EBV infection, thereby preventing unnecessary antibiotic use and enabling the correct direction of investigation and management."

Journal • Epstein-Barr Virus Infections • Infectious Disease • Otorhinolaryngology

Children with confirmed nonimmediate allergic reactions to beta-lactam antibiotics can develop tolerance after a long period of drug avoidance. (PubMed, Pediatr Allergy Immunol) - "T cell responses to βLs can subside. Children who experience NIRs to amoxicillin or amoxicillin/clavulanate can develop tolerance."

Journal • Allergy • Dermatology • Immunology • Pediatrics • Urticaria

Bacteriological profile of pilonidal sinus disease: Results of the PILOBAC study and implications for antibiotic prophylaxis (ESCP 2025) - "Bacterial species were identified, and resistance profiles to common prophylactic antibiotics (amoxicillin-clavulanate, second-/third-generation cephalosporins, and metronidazole) were analyzed...The findings question the current national recommendations and advocate for a reassessment of prophylactic protocols based on local microbial ecology and resistance patterns. A tailored antibiotic approach or even the omission of prophylaxis should be considered in minimally invasive procedures with appropriate perioperative care."

Infectious Disease • Obesity • Otorhinolaryngology

Treatment failure and adverse events after amoxicillin-clavulanate versus amoxicillin for acute sinusitis in adults (IDWeek 2025) - No abstract available

Adverse events • Clinical • Infectious Disease

Pharmacokinetic Comparison of Augmentin ES-600 and a Reduced Concentration Clavulanate Formulation in Young Children; Modeling of amoxicillin/clavulanic acid in vitro effects on bacterial growth and killing and in vivo exposure evaluation (IDWeek 2025) - No abstract available

PK/PD data • Preclinical • Infectious Disease

Smoking Cessation Leading to Ulcerative Colitis and Autoimmune Pancreatitis (ACG 2025) - "Here, we present a case of a 37-year-old-male who was newly diagnosed with both pancreatitis and severe pancolonic UC that manifested after abrupt smoking cessation.Case Description/ A 37-year-old male with a history of alcohol and tobacco use disorder presented with nausea, vomiting, diarrhea, and abdominal cramping that resolved with amoxicillin-clavulanic acid...He was transitioned to oral steroids on discharge and then initiated on infliximab and azathioprine therapy, with complete resolution UC symptoms and parenchymal pancreas injury and lesion on cross-sectional imaging with MRI...Tobacco smoking has been associated with significantly more pancreatic damage, and potentially disease relapse rates, impacting the clinical course and increasing rates of complications, such as diabetes or exocrine pancreatic insufficiency. This case highlights the complex role of nicotine in immune modulation and clinical course of UC and AIP.Figure: Figure 1: Index colonoscopy during..."

Colorectal Cancer • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immune Modulation • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Nicotine Addiction • Pancreatitis • Tobacco Addiction • Tobacco Cessation • Ulcerative Colitis

Cytological diagnosis of paracoccidioidomycosis in pleural fluid (ECP 2025) - " The hospitalized patient initially received treatment with Koide D and Dipyrone...Subsequently, Amoxicillin and Clavulanate were prescribed. After seeking care at another hospital, Clarithromycin, Atrovent inhalations, and another course of corticosteroids were added to her treatment regimen... Diagnosing paracoccidioidomycosis through pleural fluid cytology presents a significant challenge due to the rarity and complexity of identifying Paracoccidioides brasiliensis. This case underscores the importance of meticulous cytological evaluation, particularly in patients who do not respond to conventional treatments for respiratory symptoms. Accurate identification of the fungus is crucial for effective clinical management, highlighting the value of cytology as a vital, though sometimes underutilized, diagnostic tool in complex clinical scenarios."

Cough • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Coexisting hepatic actinomycosis and IgG4-related disease mimicry: a diagnostic challenge (ECP 2025) - "A multidisciplinary team agreed to treat the patient with amoxicillin/clavulanate... This unique case highlights the diagnostic complexity of hepatic lesions with IgG4 positivity in the context of infection and emphasizes the importance of differentiating between IgG4-RD and conditions that mimic it. Although persistent IgG4 elevation may be misleading, microbiological studies confirmed Actinomyces and Fuso-bacterium co-infection, allowing appropriate treatment without unnecessary intervention for IgG4-RD. At the most recent follow-up, there was a marked clinical improvement and a significant reduction in the size of the liver mass."

Anemia • Cardiovascular • Endocrine Disorders • Fibrosis • Hepatology • Immunology • Infectious Disease • Inflammation • Thrombosis

A Rare Case of TMP-SMX Induced Idiosyncratic Drug-Induced Liver Injury (ACG 2025) - "Direct DILI (dDILI) is dose-dependent, predictable, and commonly linked to agents such as acetaminophen, aspirin, tetracyclines, and vitamin A. In contrast, idiosyncratic DILI (iDILI) is dose-independent, unpredictable, and difficult to replicate in preclinical models...Agents such as amoxicillin-clavulanate, isoniazid, ciprofloxacin, and trimethoprim-sulfamethoxazole (TMP-SMX) have been implicated among antibiotics.Case Description/ We present a case of a 59-year-old female with no significant medical history who developed iDILI following a short course of TMP-SMX...TMP-SMX was discontinued, and she was treated with prednisone, famotidine, and diphenhydramine...Given the widespread use of TMP-SMX, clinicians should maintain a high index of suspicion for iDILI, particularly in patients presenting with systemic symptoms after recent drug exposure. Prompt identification, cessation of the offending agent, and supportive care are essential to prevent progression to severe..."

Clinical • Cardiovascular • Dermatology • Fatigue • Hepatology • Infectious Disease • Liver Failure • Musculoskeletal Pain • Nephrology

A Rare Complication of Hepatic Cysts in Advanced Autosomal Dominant Polycystic Kidney and Liver Disease (ACG 2025) - "Patient was empirically started on intravenous meropenem and later de-escalated to ampicillin-sulbactam...The patient improved clinically and was discharged on oral amoxicillin-clavulanate, with plans for outpatient dialysis, and outpatient kidney and liver transplant evaluation. This case highlights a rare, but serious complication of ADPKD/PLD: hepatic cyst infection leading to sepsis and AKI on CKD...Figure: Figure 1: Non-contrast CT Imaging of the Abdomen Showing Extensive Polycystic Changes in Both Kidneys and Liver, Consistent with Advanced Autosomal Dominant Polycystic Kidney and Liver Disease. Liver cyst with measurement (13.8 cm x 11 cm) indicates the hepatic cyst that was drained percutaneously, with 1000 mL serous drainage output."

Metastases • Autosomal Dominant Polycystic Kidney Disease • Chronic Kidney Disease • Genetic Disorders • Hepatology • Infectious Disease • Nephrology • Polycystic Kidney Disease • Renal Disease • Septic Shock

Rare but Real: Doxycycline-Induced Hepatocellular Liver Injury (ACG 2025) - "Several antibiotics are commonly associated with DILI, such as amoxicillin-clavulanate, sulfonamides, and isoniazid. This case emphasizes the importance of high suspicion of DILI, even with antibiotics considered relatively safe.Figure: Figure 1. Trend of LFTs improvement after doxycycline discontinuation"

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Fatigue • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Liver Failure • Lyme Disease • Psychiatry

Lawsonella clevelandensis as a Rare Cause of Complex Liver and Abdominal Wall Abscess: A Case Report and Literature Review (ACG 2025) - "The patient improved following insertion of three separate pig-tail drains and treatment with broad spectrum intravenous antibiotics that were eventually transitioned to oral amoxicillin-clavulanic acid...Clinicians should pursue molecular diagnostics when conventional cultures fail and involve infectious diseases specialists early. Recognition of this elusive pathogen can facilitate timely diagnosis and appropriate therapy, reducing morbidity associated with delayed or inadequate treatment.Figure: Contrast abdominal CT showing liver abscess at initialpresentation.Figure: Contrast abdominal CT showing abscess improvement fivemonths after initial presentation"

Case report • Clinical • Review • Diabetes • Gastrointestinal Disorder • Hepatology • Infectious Disease • Metabolic Disorders

A Rare Case of Fusobacterium Nucleatum Causing Greater Than 20 Pyogenic Hepatic Abscesses (ACG 2025) - "He was started on a heparin drip for the nonocclusive portal vein thrombus and piperacillin/tazobactam...The patient was discharged against medical advice with amoxicillin/clavulanic acid and apixaban. This case presents a patient with no significant periodontal disease however, found to have Fusobacterium nucleatum bacteremia. There have been some associations of the bacteria with colon cancer, which remains a risk in this patient has he had no historical colonoscopies. However, this case highlights the extensive disease with numerous abscess that may be formed with the organism requiring both drainage and long-term antibiotic therapy.Figure: Computed tomography of the abdomen demonstrating multi-level views of the liver with numerous, complex cystic appearing lesions with largest hepatic lesion measuring 6 cm."

Clinical • Colon Cancer • Colorectal Cancer • Dental Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Pancreatitis • Periodontitis • Solid Tumor • Thrombosis

Mesenteric Venous Ischemia Due to Splanchnic Venous Thrombosis in a Case of Clostridioides difficile Colitis (ACG 2025) - "Two weeks prior, he was treated for presumed diverticulitis at urgent care with amoxicillin-clavulanate but noted worsening symptoms...The patient began a 10-day course of vancomycin and apixaban with symptomatic improvement...showed almost twice the chance of VTE formation in C. diff positive versus negative patients (p = 0.049). Abdominal deep vein thromboses should be considered in the setting of C. diff colitis given risks in morbidity and mortality.Figure: Figure 1: CT angiogram showing filling defects are noted again in the posterior right portal vein branch.Figure: Figure 2: CT angiogram showing thrombus at the distal aspect of the main portal vein at the portal splenic confluence."

Clinical • Cardiovascular • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Septic Shock • Thrombosis • Venous Thromboembolism