amphotericin b liposome / Generic mfg. - LARVOL DELTA

Potentially Preventable? A Case of Recurrent Blastomycosis Involving the Central Nervous System. (PubMed, J Assoc Med Microbiol Infect Dis Can) - "Following surgery, the patient was once again started on voriconazole after completing a course of liposomal amphotericin B. Social work was engaged early on during this admission. A case of recurrent blastomycosis with involvement of the CNS is presented, where treatment failure occurred due to an inability of the patient to afford the required medication. Medication cost should always be considered and discussed with a patient when developing a treatment plan."

Journal • Ataxia • Infectious Disease • Movement Disorders • Pain

A Phase II, Multicentre, Randomized, Two-arm Blinded Study to Assess the Efficacy and Safety of Two LXE408 Regimens for Treatment of Patients With Primary Visceral Leishmaniasis (clinicaltrials.gov) - P2 | N=101 | Active, not recruiting | Sponsor: Drugs for Neglected Diseases | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease

Rhinocerebral Mucormycosis in New-Onset Type 1 Diabetes: A Diagnostic Challenge (ENDO 2025) - "Treatment intensified with liposomal amphotericin B, posaconazole, and targeted antibiotics (vancomycin and zosyn) leading to clinical improvement.This case highlights the critical importance of considering rhinocerebral mucormycosis in poorly controlled diabetics (especially type 1) with sinonasal/neurological symptoms. This case highlights the critical importance of considering rhinocerebral mucormycosis in poorly controlled diabetics (especially type 1) with sinonasal/neurological symptoms. Conditions that can mask the diagnosis, including bacterial co-infections, DKA, electrolyte abnormalities can delay diagnosis. Prompt, aggressive antifungal treatment and surgical debridement are crucial, given the high mortality (up to 50%)."

Cardiovascular • CNS Disorders • Diabetes • Heart Failure • Infectious Disease • Metabolic Disorders • Otorhinolaryngology • Respiratory Diseases • Sinusitis • Type 1 Diabetes Mellitus

Disseminated Saprochaete capitata Fungemia in Acute Myeloid Leukemia: A Case Report and Literature Review From the United Arab Emirates. (PubMed, Cureus) - "The isolate was resistant to fluconazole and echinocandins but susceptible to amphotericin B and voriconazole. Combination antifungal therapy with liposomal amphotericin B and voriconazole was initiated, and the PICC line was removed...Despite aggressive antifungal management, the patient developed persistent fungemia, multi-organ failure, and died on hospital day 81. This case underscores the diagnostic complexity, intrinsic antifungal resistance, and high mortality associated with S. capitata, and highlights the need for early species identification, tailored antifungal therapy, and improved fungal diagnostics in the region."

Journal • Acute Myelogenous Leukemia • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology

How to interpret MICs of amphotericin B, echinocandins and flucytosine against Candida auris (Candidozyma auris) according to the newly established EUCAST breakpoints. (PubMed, Clin Microbiol Infect) - "The following ECOFFs and breakpoints were established for C. auris: amphotericin B: ECOFF: 2 mg/L, S: ≤ 0.001 mg/L, R: >2 mg/L; implying that the entire wild-type distribution is "susceptible, Increased exposure" (I) (increased dose: 5 mg/kg liposomal amphotericin B daily); anidulafungin and micafungin: ECOFFs: 0.25 mg/L, S: ≤ 0.25; R: >0.25; rezafungin: ECOFF: 0.125 mg/L; and flucytosine: ECOFF: 0.5 mg/L. Importantly, notable MIC variations have been reported for C. auris and some agents across commercial tests. Consequently, important detailed guidance is provided on how to validate your MIC test in house before adopting the EUCAST breakpoints for MIC interpretation."

Journal • Review

Unlocking the Unreachable: Cationic ThermoSomes for Next-Generation Posaconazole Therapy. (PubMed, Mol Pharm) - "While lipid-based formulations, such as AmBisome, have achieved clinical success, scalability is restricted by high costs and complex manufacturing. Here, we have broadened the therapeutic framework of PCZ by targeting critical organs and maintaining therapeutic concentrations, which are difficult to achieve by conventional formulations. Thus, PCZ-ThermoSomes serve as a safe, stable, nontoxic, efficacious, scalable, and cost-effective alternative to existing treatment modalities for IFIs."

Journal • Candidiasis • Infectious Disease

Diagnosis and treatment of Aspergillus terreus and Klebsiella pneumoniae coinfection following myocardial infarction: A case report and literature review. (PubMed, IDCases) - "Despite aggressive antimicrobial therapy-including isavuconazole, liposomal amphotericin B, piperacillin-tazobactam, and mechanical support strategies (e.g., extracorporeal membrane oxygenation [ECMO], continuous renal replacement therapy [CRRT])-infection control was difficult. Moreover, recognizing and managing bacterial and viral coinfections are vital for optimizing patient outcomes. This case highlights the necessity of prompt, multimodal diagnostic approaches and individualized antifungal and antibacterial therapy in the management of ICU-acquired infections post-myocardial infarction."

Journal • Cardiovascular • Critical care • Cytomegalovirus Infection • Herpes Simplex • Infectious Disease • Myocardial Infarction • Pneumonia

Laryngeal Cryptococcosis in the Setting of Dupilumab Treatment: A Case Report (AAO-HNSF 2025) - "At that time, he was treated with a 14-day course of Bactrim for possible bacterial laryngitis...After ruling out disseminated infection, our patient was successfully treated with liposomal amphotericin B and a prolonged course of fluconazole... Our case represents an exceedingly unique situation in which an already rare disease presentation is coupled with a background of immunomodulation with Dupilimab. While prior studies have reported rare cryptococcal infections in patients on inhaled corticosteroids, the role of Dupilumab in cryptococcal infections has not been explored. Further research is warranted to explore the relationship between dupilumab and susceptibility to fungal infections."

Case report • Clinical • Asthma • Chronic Cough • Cough • Dermatology • Dermatopathology • Dysphonia • Immunology • Infectious Disease • Otorhinolaryngology • Rare Diseases • Respiratory Diseases • IL13 • IL4

Mucosal Leishmaniasis: From Diagnosis to New Treatment Perspectives (AAO-HNSF 2025) - "Stage I: Nodulation in the nasal septum mucosa; Stage II: Fine-grained superficial ulceration; Stage III: Deep-grained ulceration; Stage IV: Nasal septum perforation and Stage V: Destruction of the nasal pyramidAntimonial therapy remains the first-line therapy for ML across South and Central American countries due to the high cost of liposomal amphotericin B. However, this drug is associated with numerous adverse effects and contraindications.In the last two decades, newer and more effective therapies have been increasingly utilized for CL and ML, including amphotericin B, pentamidine, miltefosine, and combinations of antimony with other agents such as pentoxifylline or granulocyte/macrophage colony-stimulating factor. THIS MAKES AN EARLY DIAGNOSIS OF THE DISEASE NECESSARY. IN ADDITION TO DEMONSTRATING NEW TREATMENT ALTERNATIVES AS EARLY AS POSSIBLEComprehensive Otolaryngology Track Statement :"

Dermatology • Infectious Disease • Oncology • Otorhinolaryngology

Current trends on antifungal prophylaxis in solid organ transplantation: a study from ESCMID-EFISG, ESCMID-ESGICH, SITA, and SEIMC-GESITRA-IC. (PubMed, Infection) - "This global survey reveals substantial variation in antifungal prophylaxis practices among solid organ transplant centers, driven by a lack of standardized, evidence-based guidelines. Our findings underscore the urgent need for harmonized recommendations that reflect evolving fungal epidemiology, improved diagnostics, and new antifungal agents."

Journal • Infectious Disease • Solid Organ Transplantation • Transplantation

Disseminated paracoccidioidomycosis under biological therapy. (PubMed, J Infect Dev Ctries) - "This case highlights the risk of opportunistic infections under anti-TNF alpha therapy and raises awareness of paracoccidioidomycosis associations. Early diagnosis and management are essential for better patient outcomes."

Journal • Chronic Cough • Cough • Immunology • Infectious Disease • Mycosis Fungoides • Oncology • Pulmonary Disease • Respiratory Diseases

Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in Human Immunodeficiency Virus-associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa. (PubMed, Clin Infect Dis) - "Mortality from cryptococcal meningitis was higher in recent ART initiators. ART interruption in this group may lead to improved outcomes."

Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • CD4

A clinico-epidemiological study, assessing possible predictors of mortality and health-related quality of life for people living with visceral leishmaniasis - human immune virus (VL-HIV) co-infection in a high burden kala-azar endemic state of India: a descriptive cross-sectional study. (PubMed, BMC Infect Dis) - "The present study documents a time gap between the initiation and cessation of ART, as well as the duration from VL treatment to death. It suggests that regular adherence to ART may have a significant impact on reducing mortality and relapses. Therefore, a comprehensive people-centric approach for specific groups must be adopted for VL-HIV patients. Additional epidemiological studies on VL-HIV co-infection are warranted."

HEOR • Journal • Observational data • Retrospective data • Human Immunodeficiency Virus • Infectious Disease

Invasive Saprochaete capitata Infection in an Immunocompromised Patient With Acute Myeloid Leukemia: A Case Report. (PubMed, Cureus) - "Due to its resistance to both echinocandins and fluconazole, S. capitata presents significant treatment challenges, with no established optimal therapeutic strategy for invasive infections. Despite profound immunocompromise, the patient successfully recovered following treatment with combination antifungal therapy, which included liposomal amphotericin B and voriconazole. This case highlights the critical importance of early diagnosis and prompt initiation of appropriate antifungal therapy, particularly in immunocompromised patients, to reduce the exceptionally high mortality and morbidity associated with this severe IFI."

Journal • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology

Fatal pulmonary mycoses by Emergomyces pasteurianus in a renal transplant recipient from India. (PubMed, J Mycol Med) - "He succumbed to the illness despite antifungal therapy comprising of liposomal amphotericin B followed by itraconazole. The case emphasizes the emergence of E. pasteurianus in renal transplant recipients."

Journal • Dermatology • Infectious Disease • Respiratory Diseases • Transplantation

Management of infection and ocular complications in pediatric SJS/TEN-like acute graft-versus-host disease: a clinical case study and literature review. (PubMed, Front Immunol) - "A patient diagnosed with grade IV skin aGVHD received effective treatment for multidrug-resistant Stenotrophomonas maltophilia using minocycline, aztreonam, and ceftazidime-avibactam. Combination therapy with liposomal amphotericin B and voriconazole was efficacious against mixed fungal infections...Evaluating drug susceptibility and immune status is vital for formulating precise therapies. Early recognition and management of ocular symptoms in SJS/TEN-like aGVHD are essential to prevent irreversible damage."

Journal • Acute Graft versus Host Disease • Bone Marrow Transplantation • Graft versus Host Disease • Immunology • Infectious Disease • Ocular Infections • Pediatrics • Steven-Johnson Syndrome • Transplantation • CD4 • PD-1

Visceral leishmaniasis concealed under a diagnosis of haemophagocytic lymphohistiocytosis. (PubMed, BMJ Case Rep) - "The treating team considered a diagnosis of primary HLH and treated him with an etoposide-based regimen...Thereafter, the patient was prescribed liposomal amphotericin B, but unfortunately, he succumbed to the illness. This case reiterates that infection is a frequent trigger of sHLH. The diagnosis of primary HLH in adults should be considered only after excluding all putative infectious causes, particularly in tropical regions."

Journal • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Rare Diseases

Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient. (PubMed, Med Mycol Case Rep) - "We report the case of a 61-year-old neutropenic female with hepatosplenic T-cell lymphoma and profound neutropenia, who developed a breakthrough infection with Trichoderma longibrachiatum while receiving liposomal amphotericin B for probable invasive pulmonary aspergillosis. Trichoderma longibrachiatum and Aspergillus fumigatus were identified as causative fungal pathogens. Antifungal susceptibility testing of the T. longibrachiatum isolate revealed resistance to isavuconazole but susceptibility to amphotericin B, voriconazole, itraconazole and olorofim."

Journal • Hematological Disorders • Hematological Malignancies • Hepatosplenic T-cell Lymphoma • Infectious Disease • Lymphoma • Neutropenia • Oncology • Pulmonary Disease • Respiratory Diseases • T Cell Non-Hodgkin Lymphoma

A Rare Battle: Multidisciplinary Care for a Child with Rhino-Orbital Cerebral Mucormycosis in Somali Region of Ethiopia. (PubMed, Int Med Case Rep J) - "Treatment included intravenous liposomal amphotericin B (requiring dose adjustment for transient nephrotoxicity), extensive endoscopic nasal debridement, right eye exenteration, and intensive glycemic control...Successful management involved prompt recognition, aggressive multimodal therapy (medical and surgical), and close multidisciplinary collaboration (Pediatrics, Ophthalmology, ENT). This outcome demonstrates the feasibility of successful treatment even in resource-constrained environments and underscores the critical importance of managing underlying conditions like diabetes to prevent opportunistic infections."

Journal • Cardiovascular • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Ophthalmology • Pain • Pediatrics • Thrombosis • Type 1 Diabetes Mellitus

A TERTIARY CARE CENTRE EXPERIENCE OF INVASIVE FUNGAL INFECTIONS IN HAEMATOLOGY PATIENTS (EHA 2025) - "Initial treatment included liposomal amphotericin-B (58%), voriconazole (35%), and posaconazole (6%). Amphotericin was subsequently switched to voriconazole in 27 patients and isavuconazole in one.Among the 48 patients, 31% (n=15) succumbed to infection... IFI carry high mortality rates in haematological patients. Positive galactomannan is a surrogate marker; severity and duration of neutropenia are risk factors for mortality. Timely recognition of risk factors and use of mold-active antifungal prophylaxis may reduce mortality rates."

Clinical • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Anemia • Aplastic Anemia • B Acute Lymphoblastic Leukemia • Bone Marrow Transplantation • Dermatology • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Oncology • Otorhinolaryngology

Antifungal Use in Immunocompromised Children in Europe: A 12-Week Multicenter Weekly Point Prevalence Survey (CALYPSO). (PubMed, J Pediatr Hematol Oncol) - "All 21 HO and 10 HSCT/SOT units had prophylaxis policies for high-risk patients (27/31 used azoles, 14/31 echinocandins and 15/31 liposomal amphotericin B [LAMB])...Underdosing of micafungin for treatment in 50% of prescriptions and of fluconazole for treatment and prophylaxis in 70% of cases was noticed. In conclusion, most antifungal prescribing was for prophylaxis, with fluconazole being the main antifungal prescribed. Inadequate doses of antifungal prescribing and prophylaxis of non-high-risk patients could be targets for improvement."

Journal • Bone Marrow Transplantation • Candidiasis • Febrile Neutropenia • Hematological Disorders • Neutropenia • Oncology • Solid Organ Transplantation • Transplantation

Cryptococcosis in Pediatric Renal Transplant Recipients: Comparative Insights from Adult Cases. (PubMed, Medicina (Kaunas)) - "Management involves similar antifungal regimens such as liposomal amphotericin B, flucytosine, and fluconazole, but requires weight-based dosing and careful toxicity monitoring in pediatric patients. Early diagnosis through serum cryptococcal antigen screening, appropriate adjustment of immunosuppressive therapy, and coordinated multidisciplinary care are essential. The findings underscore the need for pediatric specific research and clinical vigilance, emphasizing tailored antifungal dosing and individualized immune management to improve outcomes in this vulnerable population."

Journal • Review • Chronic Kidney Disease • CNS Disorders • Hepatology • Infectious Disease • Nephrology • Pediatrics • Renal Disease • Respiratory Diseases • Solid Organ Transplantation • Transplantation

Comparative analysis of the nephrotoxicity of liposomal amphotericin B and amphotericin B lipid complex in hematological cancer patients: A multicenter retrospective study. (PubMed, Rev Iberoam Micol) - "Nephrotoxicity associated with L-AMB was lower than that associated with ABLC in patients with hematological cancer. Most AKI cases were mild to moderate and did not have significant short-term impact."

Journal • Retrospective data • Acute Kidney Injury • Chronic Kidney Disease • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Nephrology • Oncology • Renal Disease

Case Report: Fiberoptic bronchoscopy and thoracoscopic surgery as a treatment for pulmonary mucormycosis in pediatric acute lymphoblastic leukemia. (PubMed, Front Pediatr) - "Liposomal amphotericin B (L-AmB) remains the primary therapeutic agent for pulmonary mucormycosis, however, its efficacy is often limited...The treatment of childhood ALL complicated with pulmonary mucormycosis is particularly challenging and associated with a high mortality rate. For children with severe infections, combining antifungal therapy, such as L-AmB, with bronchoscopy and thoracoscopic surgery has been shown to be both feasible and effective."

Journal • Acute Lymphocytic Leukemia • Cough • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • Pediatrics • Respiratory Diseases

Histoplasmosis in Immunocompromised and Immunocompetent Patients in Guadeloupe. (PubMed, J Fungi (Basel)) - "Intravenous liposomal amphotericin B constituted the initial therapy in 71% of patients... Histoplasmosis in Guadeloupe is under-recognized and associated with appreciable morbidity and mortality in both immunocompromised and immunocompetent patients. The wider availability of rapid diagnostics and heightened clinical vigilance are essential to shorten diagnostic delays and improve outcomes in this Caribbean population."

Journal • Human Immunodeficiency Virus • Infectious Disease