AIC649 / AiCuris - LARVOL DELTA

Treatment with the Immunomodulator AIC649 in Combination with Entecavir Produces Antiviral Efficacy in the Woodchuck Model of Chronic Hepatitis B. (PubMed, Viruses) - "As a combination partner to Entecavir, the antiviral efficacy of AIC649 was markedly enhanced. This preclinical study supports future evaluation of AIC649 for treatment of human CHB."

Clinical • Combination therapy • IO biomarker • Journal • Hepatitis B • Hepatology • Immune Modulation • Infectious Disease • Inflammation • TLR9

First in Human, single ascending dose clinical trial of AIC649 in patients with chronic hepatitis (EASL-ILC 2019) - "A single intravenous dose of AIC649 was safe and well tolerated in all dose groups. Despite the heterogeneity of the pts in the trial, there was evidence that a single dose of AIC649 stimulates immunity."

Clinical • P1 data