AvidinOx/Lu-177 DOTA biotin / Leadiant Biosci - LARVOL DELTA

AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Cancer (clinicaltrials.gov) - P1; N=14; Terminated; Sponsor: Alfasigma S.p.A.; N=30 ➔ 14; Recruiting ➔ Terminated; Low recruitment rate

Clinical • Enrollment change • Trial termination

Safety, Tolerability, PK, Dosimetry, MTD and Preliminary Efficacy of Intra-lesionally Injected AvidinOX, Followed by IV Escalating Doses of [177Lu]DOTA-biotin in Pts With Injectable Solid Tumors or Lymphomas (clinicaltrials.gov) - P1; N=3; Terminated; Sponsor: Alfasigma S.p.A.; N=24 ➔ 3; Recruiting ➔ Terminated; low recruitment rate

Clinical • Enrollment change • Trial termination

AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Cancer (clinicaltrials.gov) - P1; N=30; Recruiting; Sponsor: Alfasigma S.p.A.; Trial primary completion date: Jan 2019 ➔ May 2019

Clinical • Trial primary completion date