ATUX-1215 / Atux Iskay Group - LARVOL DELTA

PP2a Activating Compound Sensitizes Group 3 Medulloblastoma Cells to Irradiation (Quick-Shot) (ACS-CLINCON 2024) - "PP2A activation downregulates DNA damage repair responses, leading us to hypothesize that pretreatment of human medulloblastoma patient-derived xenograft (PDX) cells with the novel PP2A activating compound, ATUX-1215, would sensitize the cells the effects of irradiation... Our findings illustrate that pretreatment with a PP2A activator, prior to XRT, sensitized the cells to irradiation. These results underscore the need for additional exploration of PP2A activators as a potential therapeutic adjunct for medulloblastoma."

Brain Cancer • Endocrine Disorders • Medulloblastoma • Oncology • Pediatrics • Solid Tumor

PP2A activation overcomes leptomeningeal dissemination in Group 3 medulloblastoma. (PubMed, J Biol Chem) - "The PP2A activators employed in this study are ATUX-6156 and ATUX-6954 (diarylmethylcycloamine sulfonylureas), and ATUX-1215 and ATUX-5800 (diarylmethyl-4-aminotetrahydropyran-sulfonamides)...The present investigation offers proof-of-principle data for PP2A-based reactivation therapy for Group 3 MB and provides the first indications that PP2A reactivation may challenge the current paradigm in targeting the 3-stage process of MB LMD. Further investigations of PP2A activators are warranted as these compounds may prove beneficial as therapeutics for MB."

Journal • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor • CASP9 • CCL2 • CCR2 • CIP2A

PP2A activation as a new therapeutic strategy in neuroblastoma: Making sense out of senescence. (ASCO 2024) - "Topotecan, a common NBL chemotherapeutic, known to induce senescence, and ATUX-1215, a small molecule PP2A activator, were utilized. Activation of PP2A with a novel small molecule ameliorates topotecan-induced TIS in NBL cells irrespective of MYCN status. These results are promising, providing a potential novel therapeutic adjunct to children who are most in need of innovative interventions."

CNS Tumor • Neuroblastoma • Oncology • Pediatrics • Solid Tumor • CCL2 • MYC • MYCN