Akis (diclofenac injection) / IBSA Institute Biochemical SA - LARVOL DELTA

Quantitative Proteomic and Metabolomic Profiling Reveals Altered Purine Metabolism in Acute Kidney Injury after On-Pump Coronary Artery Bypass Graft. (PubMed, J Proteome Res) - "Our research suggests that the panel could play a significant role in distinguishing AKIs from non-AKIs prior to surgery. We propose targeting purine metabolism pathways that may help to identify potential renal protective approaches in acute kidney injury. This study helps to reveal changes in urinary metabolomics and proteomics after CABG and may provide diagnostic clues for patients with postoperative renal injury."

Journal • Acute Kidney Injury • Nephrology • SOD2

Aurora kinases signaling in cancer: from molecular perception to targeted therapies. (PubMed, Mol Cancer) - "Researchers are also exploring combination therapies that use Aurora kinase inhibitors alongside other targeted treatments to overcome resistance and improve patient outcomes. Additionally, advancements in biomarker discovery are expected to facilitate the identification of patients most likely to benefit from Aurora kinase-targeted therapies, paving the way for more personalized approaches to cancer treatment."

Journal • Review • Oncology • AURKA • AURKB

Aurora kinases, emerging critical targets for cancer treatment and related new therapeutic strategies. (PubMed, Bioorg Chem) - "Furthermore, we reviewed the current development of a new generation of AKI, such as PROTAC degrader. Further understanding the mechanism underlying the responsiveness of AKIs could help evaluate their effect and improve them as potential therapeutic targets."

Journal • Review • Breast Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • Targeted Protein Degradation • Triple Negative Breast Cancer

Attention to early stages: predicting acute kidney injury in a post cardiosurgical ICU setting using an inclusive time-to-event model. (PubMed, Comput Biol Med) - "We demonstrated the importance of early-stage AKI predictions and presented a novel approach to achieve this. Under similar assumptions, our results showed improvement and approached outcomes comparable to the literature. While practical validation is pending, we are confident that our approach proves useful in assisting physicians to prevent AKI development."

Journal • Review • Acute Kidney Injury • Cardiovascular • Critical care • Nephrology • Renal Disease

Accuracy of Diagnostic Coding for Acute Kidney Injury in Japan-Analysis of a Japanese Hospital-Based Database. (PubMed, Pharmacoepidemiol Drug Saf) - "The ICD-10 codes for AKI showed poor positive predictive values for AKI as defined by the KDIGO criteria, suggesting that it may be difficult to identify AKI using ICD-10 codes alone in the Japanese context."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Cost-Effectiveness of Team-Based Coaching With Surveillance for Prevention of Acute Kidney Injuries. (PubMed, JAMA Netw Open) - "More than 10% of US patients undergoing endovascular procedures experience contrast-associated acute kidney injuries (AKIs), resulting in increased costs and health deficits...In this economic evaluation of implementation strategies for AKI prevention, virtual learning collaborative with automated surveillance reporting was the economically preferred intervention and was estimated to decrease AKI likelihood, permanent kidney disease, and their associated costs after undergoing cardiac catheterization. These results may be generalizable to other endovascular procedures and practice-changing protocols or checklists implementation efforts."

Clinical • HEOR • Journal • Acute Kidney Injury • Nephrology • Renal Disease

Not "a cute" complication: phenotypic analysis of acute kidney injury in Staphylococcus aureus bacteraemia. (PubMed, Clin Microbiol Infect) - "AKI is a frequent complication of SAB and is associated with 30-day mortality. Some AKI phenotypes have rapid resolution, which supports the consideration of delayed antimicrobial dose reduction."

Journal • Retrospective data • Acute Kidney Injury • Nephrology • Renal Disease

Advances in the Design, Discovery, and optimization of aurora kinase inhibitors as anticancer agents. (PubMed, Expert Opin Drug Discov) - "The integration of artificial intelligence and computational approaches is poised to accelerate the development of AKIs as anticancer agents. However, the associated challenges currently hindering its impact in drug development must be overcome before drugs can successfully translate from early drug development into clinical practice."

Journal • Review • Oncology

Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease. (PubMed, Clin Kidney J) - "AKIs and adverse drug reactions (ADRs) were prospectively identified from hospital reports, medical records, and patient interviews...Drug-related AKI is prevalent among patients with CKD. Even though a substantial proportion of these events were classified as stage 1, our findings point to a poor prognosis."

Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Nephrology • Renal Disease

Understanding rhabdomyolysis induced acute kidney injury in patients with COVID-19. (PubMed, World J Virol) - "It is clear from these findings that clinicians must closely monitor and assess for the presence of rhabdomyolysis in COVID-19 patients who have developed AKIs. Moreover, additional research is required to further understand the mechanisms behind the development of RIAKI in COVID-19 patients in order to better inform treatment guidelines and protocols."

Journal • Acute Kidney Injury • Infectious Disease • Musculoskeletal Pain • Nephrology • Novel Coronavirus Disease • Pain • Renal Disease • Respiratory Diseases • CRP • MB

A cost effectiveness analysis of a quality improvement intervention to increase preferential balanced fluid prescribing. (PubMed, BMC Health Serv Res) - "The QI intervention was predicted to improve patient outcomes while yielding significant cost-savings. The marginally increased cost of balanced fluids should not discourage implementation of interventions aimed at increasing evidence-supported balanced fluid prescribing."

Cost effectiveness • HEOR • Journal • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Acute Kidney Injury Secondary to Hypertension-Related Thrombotic Microangiopathy: A Case Report and Literature Review. (PubMed, Cureus) - "The presence of acute kidney injuries (AKIs) in adults with microangiopathic hemolytic anemia and thrombocytopenia poses diagnostic and therapeutic challenges, as there are numerous causes that cannot always be rapidly differentiated...We report a case of AKI secondary to hypertension-related thrombotic microangiopathy and describe the clinical course from presentation to diagnosis and treatment. The patient remained hemodialysis-dependent despite attempts to control the blood pressure and administer anticomplement treatment."

Journal • Review • Acute Kidney Injury • Atypical Hemolytic Uremic Syndrome • Cardiovascular • Complement-mediated Rare Disorders • Hematological Disorders • Hypertension • Nephrology • Renal Disease • Thrombocytopenia

Drug-induced acute kidney injury: a cohort study on incidence, identification of pathophysiological mechanisms, and prognostic factors. (PubMed, Front Med (Lausanne)) - "Most nephrotoxic drugs caused type A reactions, with Vancomycin being the primary nephrotoxin. Although the mortality rate is lower among DI-AKIs compared to other AKI etiologies, the need for AKST was similar. Therefore, it is recommended that DI-AKI be recognized early to enable dose reduction or even drug suspension, depending on the type of reaction, to reduce healthcare costs and improve clinical outcomes for patients."

Biomarker • Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Prevalence of acute kidney injury and outcome in cats treated as inpatients versus outpatients following lily exposure. (PubMed, J Am Vet Med Assoc) - "Results of our study suggested that IP cats have a superior outcome than OP cats; however, cats treated as OPs may still have favorable outcomes."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Longitudinal Changes in Estimated Glomerular Filtration Rate Following Repeat Heart Transplant in Children and Young Adults. (PubMed, Pediatr Transplant) - "This study provides data on longitudinal changes in eGFR over 6 years and finds that female sex and repeat HT recipients with greater 2 AKIs between transplants are at greatest risk for CKD3 presence post-RT."

Journal • Retrospective data • Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Renal Disease • Transplantation

Rhabdomyolysis-related acute kidney injury in patients with COVID-19. (PubMed, World J Virol) - "Rhabdomyolysis was present in 13.0% of the patients who had AKI during COVID-19 infection. Rhabdomyolysis-related AKI is more proinflammatory and has a more mortal clinical course."

Journal • Acute Kidney Injury • Infectious Disease • Inflammation • Nephrology • Novel Coronavirus Disease • Renal Disease • Respiratory Diseases • CRP

Postoperative Fluid Accumulation is Associated With Underestimation of AKI Severity in Lung Transplant Recipients. (PubMed, Clin Transplant) - P=N/A | "Adjusting for FB and evaluating renal recovery patterns post-AKI may enhance the sensitivity of AKI detection. This approach could help identify patients with poor prognosis and potentially improve outcomes in lung transplant recipients."

Journal • Retrospective data • Acute Kidney Injury • Nephrology • Renal Disease • Transplantation

Stent vs Stent-Less Ileal Conduits After Radical Cystectomy: Is There a Difference in Early Postoperative Outcomes? (PubMed, Urol Pract) - "There was no significant difference in 30-day rates of UTIs, AKIs, renal failure, ileoileal anastomotic leaks, ureteral obstruction, reoperations, and readmissions...Stent-less patients had non-inferior outcomes compared to stented patients in most important 30-day outcomes. Our analysis suggests that stents may not be necessary in ileal conduit urinary diversion procedures."

Journal • Acute Kidney Injury • Bladder Cancer • Genito-urinary Cancer • Infectious Disease • Nephrology • Oncology • Renal Disease • Small Intestinal Carcinoma • Solid Tumor

Acute Kidney Injury and Its Association With Dementia and Specific Dementia Types: Findings From a Population-Based Study in Sweden. (PubMed, Neurology) - "Individuals who experienced an AKI were at increased risk of receiving a diagnosis of dementia."

Journal • Acute Kidney Injury • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Lewy Body Disease • Movement Disorders • Nephrology • Parkinson's Disease • Renal Disease

AURKA activates FOXO3a to form a positive feedback loop in the proliferation and migration of keloid fibroblasts. (PubMed, Adv Wound Care (New Rochelle)) - "AURKA/FOXO3a loop promotes the proliferation and migration of keloid fibroblasts via AKT signaling. Despite the anti-keloid effects of AKIs, AURKA acts as a transcription factor independently of kinase activity, deepening our understanding on AKI insensitivity."

Journal • Fibrosis • Oncology • AURKA

Nephrons and non-relapse mortality: simplified comorbidity index and acute kidney injury are associated with NRM in adults undergoing allogeneic hematopoietic cell transplant. (PubMed, Front Transplant) - "Through multivariate analysis, we found that patients with an SCI of greater than 4 had a higher risk of NRM. Additionally, we noted that AKIs stages 2-3 prior to day +100 was independently associated with a 3-fold greater NRM than patients who did not experience clinically significant AKI."

Journal • Acute Kidney Injury • Bone Marrow Transplantation • Chronic Kidney Disease • Nephrology • Renal Disease • Transplantation

Acute Kidney Injury Duration and 20-Year Risks of CKD and Cardiovascular Disease. (PubMed, Kidney Int Rep) - "AKIs were categorized as rapid reversal AKI (≤48 hours), persistent AKI (2-7 days), and acute kidney disease (AKD) (>7 days)...However, persistent AKI was associated with a slightly increased aHR of heart failure (1.09; 95% CI, 1.02-1.16), and aHRs of heart failure, ischemic heart disease, and peripheral artery disease were slightly increased for AKD (1.09 [95% CI, 1.03-1.15], 1.11 [95% CI, 1.03-1.19], and 1.10 [95% CI, 1.02-1.17], respectively). AKI duration was associated with development of CKD, but not overall CVD; however, rates of heart failure, ischemic heart disease, and peripheral artery disease increased slightly with AKI duration."

Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Nephrology • Peripheral Arterial Disease • Renal Disease

Increased risk of acute kidney injury in the first part of an ultra-trail-Implications for abandonment. (PubMed, Physiol Rep) - "Acute kidneys injuries (AKIs) have been described in marathon and trail running...The consumption of NSAIDs (nonsteroidal anti-inflammatory drugs) before or during an ultra-distance race should therefore be prohibited. Attention should be paid to hydration disorders."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

A comprehensive review on role of Aurora kinase inhibitors (AKIs) in cancer therapeutics. (PubMed, Int J Biol Macromol) - "The drawbacks of existing inhibitors like selectivity, drug resistance and toxicity have also been addressed. Since, majority of inhibitors are Aurora kinase inhibitor (AKI) type-1 that bind to the active (DFGin and Cin) conformation of the kinase, this information may be utilized to design highly selective kinase inhibitors that can be combined with other therapeutic agents for better clinical outcomes."

Journal • Review • Oncology • Solid Tumor • AURKA • AURKB

Acute Kidney Injury in Different Anticoagulation Strategies: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data. (PubMed, Cardiovasc Drugs Ther) - "Particular attention should be directed toward monitoring renal function in individuals receiving anticoagulants, including warfarin and direct oral anticoagulants, as well as other anticoagulant agents. This diligence is particularly imperative within the first month after anticoagulant administration for individuals with a tendency for AKI."

Journal • Real-world • Real-world evidence • Acute Kidney Injury • Glomerulonephritis • Hematological Disorders • Nephrology • Renal Disease