amisulpride / Generic mfg. - LARVOL DELTA

Following the Action of Atypical Antipsychotic Clozapine and Possible Prediction of Treatment Response in Schizophrenia. (PubMed, Life (Basel)) - "Clozapine is one of the most effective antipsychotics, and there is potential to improve performance by combining it with different compounds to limit adverse effects or by augmenting it with other antipsychotics (amisulpride, paliperidone), other active substances with different properties (minocycline, N-acetylcysteine, memantine), or alternative therapies (electroconvulsive therapy, repetitive transcranial magnetic stimulation). There are also significant steps in optimizing clozapine efficacy by predicting treatment response, which could be determined by testing the following: plasma levels of clozapine N-oxide and N-desmethylclozapine, serum levels of neurotrophins and glutamate, genetic testing, the polygenic risk score, morphometry, or even the identification and accurate determination of persistent negative symptoms."

Journal • Review • CNS Disorders • Depression • Psychiatry • Schizophrenia • ADRA1B • RPS6

Efficacy of Antipsychotic Treatment for Delusional Infestation: A Retrospective Cohort Study. (PubMed, J Cutan Med Surg) - "Amisulpride, followed by paliperidone and risperidone, emerged as the most effective treatments for DI, with the greatest reductions in symptom severity, confirming previous studies. The effect is significant over time."

Journal • Retrospective data • CNS Disorders • Dermatology • Mental Retardation • Psychiatry

Impact of Early Antipsychotic Prescription Choice on Weight Gain in the First 5 Years of Psychotic Illness: a Retrospective Cohort Study. (PubMed, Neurol Ther) - "Younger women were at elevated risk for weight gain as were people prescribed multiple antipsychotics in the 1st year. Some older antipsychotics associated with as much weight gain as the newer prescribed agents. More than 40% of people did not put on weight."

Journal • Retrospective data • CNS Disorders • Obesity • Psychiatry • Schizophrenia

Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysis. (PubMed, EClinicalMedicine) - "Clozapine showed superior efficacy for overall symptoms compared to haloperidol, chlorpromazine, quetiapine, and sulpiride (SMDs 0.35 to 1.00). It slightly outperformed olanzapine for positive symptoms (SMD 0.19; 95% CI 0.00 to 0.37) and risperidone for response rates (OR 0.64; 95% CI 0.41 to 1.01). Clozapine combinations with amisulpride, duloxetine, memantine, mirtazapine, topiramate, and ziprasidone improved overall symptoms more than clozapine monotherapy (SMDs -1.53 to -0.51)...These results emphasise the need for personalised treatment, further research comparing non-clozapine antipsychotic combinations to high-dose clozapine monotherapy, and studies on long-term outcomes. None."

Journal • Retrospective data • CNS Disorders • Psychiatry • Schizophrenia

Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2. (PubMed, J Med Chem) - "High-affinity substrates included berberine, pentamidine, and amisulpride, while epinephrine and atenolol had the highest Vmax. However, machine learning classifiers using 15 parameters allowed 69 to 87% correct prediction. The large number of substrates indicates a possibly broad role of multidrug and toxin extrusion (MATE) transporters in pharmacokinetics and drug interactions."

Journal • SLC22A1

Temporal Dynamics of Gut Fungi in Drug-Naïve First-Episode Schizophrenia Patients During Antipsychotics Treatment (CINP-AsCNP 2025) - "We analyzed fungal composition and abundance alterations at four time points (baseline, 4 weeks, 8 weeks, and >12 weeks) during treatment with antipsychotics (olanzapine, risperidone, aripiprazole, and amisulpride) and assessed changes in fungal networks over time. Our study demonstrated that the gut fungal community in SCZ patients undergoes dynamic changes during antipsychotic treatment. These findings highlight the importance of considering temporal changes in gut mycobiota of microbiota research related to schizophrenia."

Clinical • CNS Disorders • Psychiatry • Schizophrenia

Bidirectional modulation of reward-guided decision making by dopamine. (PubMed, Psychopharmacology (Berl)) - "Together, our data provide evidence for a role of dopamine in controlling the influence of value parameters on choice irrespective of decision strategies."

Journal

A Review of the Literature on Case Reports Describing Post-Stroke Psychosis Treatment (APA 2025) - "All 9 patients were treated with antipsychotics, with olanzapine used in 5 cases, risperidone in 3 cases, aripiprazole in 2 cases, quetiapine in 1 case, amisulpride in 1 case, and clozapine in 1 case. Prior studies show that right hemispheric lesions, history of mental health problems, and pre-existing subcortical atrophy may be risk factors for post-stroke psychosis. This literature review included cases with right-sided or bilateral lesions. The majority of cases included patients without past psychiatric histories, which is not consistent with the literature but was based on a small sample size."

Case report • Clinical • Review • Cardiovascular • CNS Disorders • Psychiatry

Unsupervised Graph Clustering Reveals a Clinical Taxonomy of Antipsychotics (APA 2025) - "Cluster 1 contained Aripiprazole, Brexpiprazole, Cariprazine, Lurasidone, Sertindole, and Ziprasidone, and was characterized by an excellent side-effect profile but also with the lowest efficacy. Cluster 2 contained Chlorpromazine, Haloperidol, Loxapine, Molindone, Perphenazine, and Thiothixene, and showed strong efficacy in positive symptoms, but also had a high-risk for EPS, QTc prolongation and seizures. Cluster 3 contained Clozapine, Iloperidone, Olanzapine, Quetiapine, Thioridazine, and Zotepine, and showed strong overall efficacy but carried the highest risk for sedation and metabolic side effects. Cluster 4 contained Amisulpride, Asenapine, Paliperidone, Risperidone, and Sulpride, and showed excellent positive and negative symptom efficacy but carried the highest risk of hyperprolactinemia. Cluster 5 contained Flupentixol, Fluphenazine, Pimozide, and Trifluoperazine and showed the lowest efficacy with a high risk of causing EPS. Conclusion Despite traditional..."

Clinical • Anesthesia • CNS Disorders • Epilepsy • Hypotension • Psychiatry • Schizophrenia

Comparative mortality risk of antipsychotics in 41,695 patients with schizophrenia: an 11-year population-based cohort study in Hong Kong. (PubMed, Eur Neuropsychopharmacol) - "Several commonly-used second-generation-antipsychotics (olanzapine (Zyprexa)/quetiapine/risperidone (Risperdal)/aripiprazole/amisulpride) were also associated with reduced mortality-risk relative to perphenazine. Our results highlight that mortality-risk is differentially associated with various antipsychotics and regimens, and indicate the critical role of clozapine and LAI antipsychotics in alleviating excess mortality-risk. Our findings underscore the importance of ensuring early access to clozapine and LAI antipsychotics to optimize psychiatric and physical outcomes in schizophrenia patients."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Development of a method for rapid determination of 98 PPCPs in drinking water by SPE-UPLC-MS/MS. (PubMed, Anal Methods) - "Residues such as amisulpride and 1,7-dimethylxanthine were detected in water samples. This method is simple, sensitive, and suitable for high-throughput detection of trace PPCPs in drinking water, providing reliable technical support for water quality monitoring."

Journal

AMISULPRIDE FOR THE TREATMENT OF IDIOPATHIC GASTROPARESIS: RESULTS OF A DOUBLE-BLINDED PLACEBO-CONTROLLED STUDY (DDW 2025) - No abstract available

Clinical • Gastrointestinal Disorder

Antipsychotics cause reversible structural brain changes within one week. (PubMed, Neuropsychopharmacology) - "Within arms, participants were randomized to receive daily doses of either the active compound (Arm 1= amisulpride 400 mg/day, N = 24; Arm 2= aripiprazole 10 mg/day, N = 24) for one week, followed by placebo or vice versa. Short-term exposure to either one of two different antipsychotics results in a transient increase in striatal volume measured with T1-weighted MRI that normalizes rapidly on stopping treatment without cortical changes. Our findings suggest that striatal volumetric MRI differences detected in people with schizophrenia taking antipsychotics are, at least in part, attributable to pharmacological effects."

Clinical • Journal • CNS Disorders • Psychiatry • Schizophrenia

Bioequivalence and Safety of Two Amisulpride Formulations in Healthy Chinese Subjects Under Fasting and Fed Conditions: A Randomized, Open‑Label, Single‑Dose, Crossover Study. (PubMed, Drugs R D) - "The test and reference amisulpride formulations were bioequivalent under fasting and fed conditions. Both formulations showed similar safety and tolerability in the population studied."

Journal • CNS Disorders

Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery (clinicaltrials.gov) - P2 | N=276 | Recruiting | Sponsor: Instituto do Cancer do Estado de São Paulo | Not yet recruiting ➔ Recruiting

Enrollment open • Gynecology

Aripiprazole alleviates the high prolactin levels induced by amisulpride via distinct molecular mechanisms: a network pharmacology and molecular docking study. (PubMed, BMC Psychiatry) - "These findings highlight the distinct signaling pathways and molecular networks involved in prolactin regulation by aripiprazole and amisulpride and provide new insights into the mechanisms of these drugs in schizophrenia treatment. Further pharmacological and clinical research is needed to validate the complex regulatory networks and in vivo effects."

Journal • CNS Disorders • Psychiatry • Schizophrenia • CDC42 • DRD2 • ER • MAPK3 • MMP9 • PPARG

Photodegradation of psychotropic medications: Impact on efficacy, safety, and drug properties. (PubMed, Comput Biol Med) - "Our results indicate that photoproducts such as amisulpride_TP166, TP246, quetiapine_D4, and quetiapine_PH1 show enhanced biological affinity and ADME-Tox profiles similar to their parent compounds, suggesting possible therapeutic advantages in their interaction with targeted receptors. However, some of the photocompounds exhibit lower predicted binding affinities when interacting with those receptors compared to their parent compounds, indicating a possible loss of function. These findings emphasize the need for further investigation into the effects and safety of drug photoproducts, particularly in the context of long-term pharmacotherapy."

Journal • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry • Schizophrenia

Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT) (clinicaltrials.gov) - P3 | N=762 | Completed | Sponsor: Shanghai Mental Health Center | Unknown status ➔ Completed | Phase classification: P4 ➔ P3 | N=1260 ➔ 762

Enrollment change • Phase classification • Trial completion • CNS Disorders • Psychiatry • Schizophrenia

Drug-associated hyperprolactinemia: a comprehensive disproportionality analysis based on the FAERS database. (PubMed, Eur J Pharmacol) - "Sensitivity analysis indicated that most signals remained robust, with risperidone exhibiting the strongest signal for HPRL, followed by amisulpride, paliperidone, fluphenazine, and thioridazine. In conclusion, we identified and ranked drugs associated with HPRL, primarily psychotropic medications, and observed variations in signal strength and onset time across gender and age. These findings emphasize the importance of individualized HPRL screening based on specific medications, gender, and age."

Journal • CNS Disorders

Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients At High Risk for Nausea and Vomiting Undergoing Gynecological Surgery (clinicaltrials.gov) - P2 | N=276 | Not yet recruiting | Sponsor: Instituto do Cancer do Estado de São Paulo

New P2 trial • Gynecology

QT Interval, Antipsychotics and Correlates Among Patients with Schizophrenia: Cross-Sectional Data from the Multicentric Real-World FACE-SZ. (PubMed, Drug Saf) - "The prescription of antipsychotics should always be accompanied by close monitoring of the QTc interval to prevent the risk of severe cardiac arrhythmia, particularly concerning clozapine."

Journal • Real-world evidence • Cardiovascular • CNS Disorders • Psychiatry • Schizophrenia

Paliperidone-induced neuroleptic malignant syndrome: A case report. (PubMed, Medicine (Baltimore)) - "Although NMS is not very common in patients using antipsychotics, it is important because it is an emergency condition that can result in death if not treated appropriately. Clinicians should consider NMS in patients taking atypical antipsychotics such as paliperidone."

Journal • Cardiovascular • CNS Disorders • Movement Disorders • Psychiatry • Schizophrenia

Aborted Sudden Cardiac Death Due to Acquired QT Prolongation: A Case Report. (PubMed, Cureus) - "We present the case of a 60-year-old woman with a history of schizoaffective disorder treated with escitalopram and amisulpride and a recent prescription for ciprofloxacin for a urinary tract infection, who was admitted following a cardiac arrest. This case highlights the importance of thorough medication review and early identification of individuals at risk for acquired LQTS to prevent potentially fatal arrhythmias. It also highlights the necessity of considering underlying genetic predisposition, especially in cases where QT prolongation persists despite the discontinuation of the offending agents and/or correction of other contributing factors, making genetic testing advisable in selected patients, as it will guide further management."

Journal • Cardiovascular • CNS Disorders • Endocrine Disorders • Heart Failure • Infectious Disease • Nephrology • Psychiatry • Schizophrenia

Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system. (PubMed, BJPsych Open) - "Ziprasidone, amisulpride and olanzapine are associated with increased risk of QTc prolongation. Regular electrocardiogram monitoring is recommended when clinicians prescribe such drugs."

Journal • Real-world evidence • Retrospective data • Cardiovascular • CNS Disorders

Antipsychotic drug dosing and study discontinuation in schizophrenia: A systematic review and dose-response meta-analysis. (PubMed, Eur Neuropsychopharmacol) - "Dose discontinuation curves varied between the antipsychotics and included U-shaped, monotonic, and hyperbolic patterns. Future studies should consistently present disease-related and side-effect-related dropouts due to adverse events separately."

Journal • Retrospective data • Review • CNS Disorders • Psychiatry • Schizophrenia