A244/B.63521 with ALFQ adjuvant / U.S. Army Medical Research and Development Command - LARVOL DELTA

Identifying and sorting live vaccine-specific B cells from peripheral blood and bone marrow using spectral enhanced flow cytometry (IMMUNOLOGY 2025) - "To refine assay parameters, peripheral blood (PB) and bone marrow (BM) samples were isolated from non-human primates (NHPs) that received a bivalent group M HIV mRNA vaccine with or without a boost of A244+B.63521 adjuvanted with ALFQ...Our preliminary results show that this technique successfully identified and sorted HIV-specific ASCs in NHP samples. This refined technique will be used to detect ASCs in preclinical and clinical vaccine and therapeutic trials to further inform future vaccination strategies and capture novel bnAbsKeywords: Animals Human Non-Human Primate; Cells B Cells; Infections AIDS Viral"

Human Immunodeficiency Virus • Immunology • Infectious Disease • Oncology

RV 575 study: a phase 1 double blinded dose optimization study of ALFQ adjuvant with an HIV envelope vaccine containing A244 and B.63521... results of a blinded interim analysis (HIVR4P 2024) - "Preliminary blinded data show ALFQ-adjuvanted bivalent HIV-1 vaccine is safe and well-tolerated. Binding antibody titers and CD4+ T-cell responses were ALFQ dose-dependent and increased with the first two vaccinations."

Clinical • P1 data • Fatigue • Human Immunodeficiency Virus • Infectious Disease • Musculoskeletal Pain • Pain • CD40LG • IFNG • IL2 • TNFA

Safety, Tolerability, and Immunogenicity of ALFQ in a HIV Vaccine Containing A244 and B.65321 in Healthy Adults (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: U.S. Army Medical Research and Development Command | Not yet recruiting ➔ Recruiting

Enrollment open • Human Immunodeficiency Virus • Infectious Disease • CD4 • CD8

Safety, Tolerability, and Immunogenicity of ALFQ in a HIV Vaccine Containing A244 and B.65321 in Healthy Adults (clinicaltrials.gov) - P1 | N=60 | Not yet recruiting | Sponsor: U.S. Army Medical Research and Development Command

New P1 trial • Human Immunodeficiency Virus • Immunology • Infectious Disease • CD4 • CD8