AF106 / Afimmune - LARVOL DELTA

Examining antifungal activity of elexacaftor/tezacaftor/ivacaftor against Aspergillus fumigatus biofilms (NACFC 2024) - "We also treated A. fumigatus biofilms with ETA in combination with caspofungin, micafungin, or anidulafungin and assessed growth recovery after treatment...Af106-6.10 is also as or more susceptible to ETI in the CF-relevant stress conditions than standard laboratory conditions... ETI is effective at reducing A. fumigatus biofilm biomass in CF lung-relevant conditions. It increases the efficacy of echinocandins against A. fumigatus biofilms. A CF aspergillosis in vivo mouse model is in early development in our laboratory to test the impact of ETI against A. fumigatus biofilms alone and in combination with echinocandins in the mammalian lung."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Respiratory Diseases

Novel diversity of plasmatic thrombin pools to regulate Blood Clotting: Interference by an anti-fibrin nanobody (GTH 2024) - "Method A novel Syn-Nb-AF106 anti-fibrin nanobody (Nb106) was characterized, as described in Sun et al...One pool of soluble thrombin steers the proteolytic coagulation cascade, while a second pool is bound to growing fibrin fibers. The latter pool still cleaves TG substrate, is temporarily protected against antithrombin, and is required for fibrin fiber extension and blood clotting and clot retraction."

Thrombosis

Diversity of Plasmatic Thrombin Pools Regulate Thrombin Generation and Blood Clotting: Interference By a Novel Nanobody (ASH 2023) - "Collectivity, these data point to the existence of two major pools of proteolytically active thrombin, both of which contributing to thrombin generation, that are formed upon plasma and blood coagulation. One pool of soluble thrombin steers the proteolytic coagulation cascade, while another pool is bound to growing fibrin fibers. The latter pool still cleaves the conventional AMC thrombin substrate, is temporarily protected against antithrombin, and is required for fibrin fiber extension and blood clotting and clot retraction."

Thrombosis

Pattern of Allergic Sensitization in Lagos, Nigeria: Informing Cost Effective Testing for a Low Resource Setting (ATS 2023) - "The frequencies of positive tests were as follows: DP 239/392 (61%), DF 235/389 (60.4%), GC 186/392 (47.4%), AF 106/392 (27%), DD 54/215 (25.1%), BT 16/80 (20%), GM 71/371 (19.1%), AA 10/82 (12.2%) and BG 23/242 (9.5%)... Indoor allergens comprising dust mites (DP and DT), arthropod (GC) and fungi (AF) produced most aeroallergen sensitization in Lagos. These should be prioritized in testing panels in this locality. GM should be selected over BG as outdoor allergen."

Cost effectiveness • HEOR • Allergy • Asthma • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases

[VIRTUAL] Aspergillus fumigatus persistence and infection in cystic fibrosis: Adaptation to hypoxia and in vivo HOG pathway mutation (NACFC-I 2021) - "Clade 2 isolates have conserved phenotypes such as tolerance to osmotic stress and voriconazole, as well as reduced growth under normal oxygen conditions. Taken together, these results reveal new insights into adaptation mechanisms of Af CF isolates"

Preclinical • Allergic Bronchopulmonary Aspergillosis • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases