amantadine / Generic mfg. - LARVOL DELTA

Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report. (PubMed, Vet Med Sci) - "All clinical signs secondary to the amantadine toxicity resolved following intravenous lipid emulsion therapy and remained normal on 24 h, day 5, day 18, and day 50. This represents the first report of amantadine toxicity in a clinical setting and is the first case showing that intravenous lipid emulsion therapy could be an effective treatment for amantadine toxicity."

Journal • Movement Disorders • Ophthalmology

Correlation of motor symptoms and cardiovascular dysfunction in Parkinson's disease (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "Obtained data indicate the presence in patients with the initial stages of PD of autonomic CV dysfunction, closely related to the motor (especially walking and postural balance) symptoms of PD by a single neurodegenerative process covering both central and peripheral structures of the autonomic nervous system."

Journal • Cardiovascular • CNS Disorders • Hypertension • Hypotension • Movement Disorders • Parkinson's Disease

Acute liver injury and diffuse subcutaneous pneumatosis following compound paracetamol and amantadine hydrochloride tablets poisoning: a case report. (PubMed, Front Pharmacol) - "Acute liver injury and diffuse subcutaneous pneumatosis affecting multiple regions, caused by the ingestion of a large quantity of Compound paracetamol and Amantadine hydrochloride tablets, is a rare occurrence. With early gastric lavage, blood purification, and supportive therapy, the patient was successfully treated and discharged."

Journal • Critical care • Hepatology • Liver Failure • Pain • Psychiatry

FIFTY-YEAR ANALYSIS OF INFLUENZA VACCINE EFFECTIVENESS AND ANTIVIRAL USE PATTERNS THROUGH MACHINE LEARNING: IMPLICATIONS FOR PAEDIATRIC INFLUENZA MANAGEMENT (ESPID 2025) - "Data were stratified by virus subtypes, including Influenza A(H1N1), A(H3N2), and Influenza B, as well as by the use of major antivirals such as Amantadine, Rimantadine, Zanamivir, Oseltamivir, Peramivir, and Baloxavir...Conclusions/Learning Points This analysis highlights the dynamic nature of influenza vaccine effectiveness and antiviral medication consumption over five decades. The findings underscore the necessity of ongoing research, global surveillance, and adaptability in influenza prevention and treatment strategies to address changing epidemiological patterns, particularly in vulnerable populations such as children."

Machine learning • Infectious Disease • Influenza

A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid (clinicaltrials.gov) - P2 | N=30 | Recruiting | Sponsor: University of Texas Southwestern Medical Center | Trial completion date: Jun 2025 ➔ Oct 2025 | Trial primary completion date: May 2025 ➔ Sep 2025

Trial completion date • Trial primary completion date • Cognitive Disorders • Infectious Disease • Novel Coronavirus Disease

AmantadineLC: Amantadine Therapy for Cognitive Impairment in Long COVID (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: Ohio State University | Phase classification: P1 ➔ P2 | Trial completion date: May 2025 ➔ Dec 2025 | Trial primary completion date: Apr 2025 ➔ Dec 2025

Phase classification • Trial completion date • Trial primary completion date • Cognitive Disorders • Infectious Disease • Novel Coronavirus Disease

The Presence of an Absence: Withdrawal of Dopaminergic Medications Leading to Neuroleptic Malignant Syndrome (ATS 2025) - "The patient's family admitted confusion regarding his home PD medications (including both carbidopa/levodopa and amantadine) in the setting of multiple, differing prescriptions...Next, the supportive, ICU care necessary included common interventions and also rare interventions like dantrolene. Finally, non-oral PD formulations or carbidopa/levodopa ODT may help prevent NMS in acute ill PD patients with severe dysphagia. Hospital pharmacies should strategically stock at least one form of them."

Acute Kidney Injury • CNS Disorders • Gastrointestinal Disorder • Movement Disorders • Nephrology • Parkinson's Disease • Renal Disease

Amantadine-Induced Hypoglycemia in a Patient Without a History of Diabetes Mellitus (ATS 2025) - "This abstract is funded by: none Introduction : Hypoglycemia, a state of low blood glucose, has multiple etiologies with the most common being drug-induced hypoglycemia particularly in individuals with a history of diabetes with insulin, sulfonylureas, and metformin as the most frequent offenders. Amantadine was discontinued with notable stable improvement in blood glucose levels.Discussion : Amantadine has been demonstrated to decrease glucagon levels and increase insulin levels which could potentially lead to hypoglycemia.3 While the etiology of hypoglycemia in this case is possibly multifactorial given the recent decreased PO intake, infection and poor reserves, Amantadine as a possible culprit was highly likely given the negative work up for other instigating factors. In essence, this case highlights the importance of comprehensive history taking and medication reconciliation in hospitalized patients."

Clinical • Asthma • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • CNS Disorders • Diabetes • Endocrine Disorders • Epilepsy • Glaucoma • Hypoglycemia • Immunology • Infectious Disease • Metabolic Disorders • Movement Disorders • Multiple Sclerosis • Ophthalmology • Osteoporosis • Parkinson's Disease • Pneumonia • Psychiatry • Respiratory Diseases • Rheumatology • Schizophrenia

D-Cycloserine, a potential candidate for reducing hepatitis B virus cccDNA in vitro. (PubMed, J Virol Methods) - "Among them, several chemicals including danoprevir, L- and D-cycloserine, phenytoin sodium, amantadine, and germacrone showed a decrease in cccDNA levels. Especially, D-cycloserine diminished the secretion of HBV antigens and induced cccDNA degradation in the HBV infection system. This screening system helps to develop the therapeutic drug target to cccDNA This screening system may help develop therapeutic drugs targeting cccDNA."

Journal • Preclinical • Fibrosis • Hepatitis B • Hepatitis C • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Inflammation • Oncology • Solid Tumor

Toward Personalized Medicine: The Effect of Treatment of Chronic Enterovirus Diarrhea in an Immunocompromised Patient and the Correlation With In Vitro Models. (PubMed, Open Forum Infect Dis) - "To explore treatment options, we assessed the presence of neutralizing antibodies (nAbs) against CVA1 in pooled IVIG from South Africa, where EV-Cs are prevalent, and tested the antiviral efficacy of US Food and Drug Administration-approved drugs like fluoxetine, itraconazole, ribavirin, and remdesivir (RDV) against CVA1 in vitro...The patient, treated with Dutch IVIG, also received a combination of amantadine and fluoxetine, which were discontinued due to side effects...In concordance with unfavorable antiviral response in the patient, preliminary tests on a co-culture model containing isogenic human intestinal cells and intestinal fibroblasts showed no significant reduction in CVA1 RNA copies after RDV administration. In conclusion, our results showed that repurposing of drugs that have shown in vitro efficacy does not translate well to the patients, and this is also reflected in a more physiologically relevant model of the human intestine."

Journal • Preclinical • Infectious Disease • Oncology • Primary Immunodeficiency • Rhabdomyosarcoma • Sarcoma • Solid Tumor

Stable expression of SARS-CoV-2 envelope viroporin promotes intracellular calcium depletion in human cells: relevance for endoplasmic reticulum stress, cell proliferation, pluripotency and lineage differentiation. (PubMed, Cell Calcium) - "Electrophysiological recordings in HEK293 cells revealed E-protein self-assembles in the plasma membrane to mediate a cation efflux pore that is sensitive to amantadine blockade. Calcium fluorescence imaging in HEK293 and hiPS cells demonstrated E-protein expression induces a marked depletion of thapsigargin-sensitive intracellular calcium stores...Finally, trilineage differentiation of hiPS cells indicated E-protein expression preserves cell pluripotency while selectively impairs mesodermal differentiation. These results unveil a critical role of stable E-viroporin expression that through alteration of ER Ca²⁺ homeostasis, metabolic activity and induction of ER stress affects important cellular functions, including the differentiative process from pluripotent to mesodermal progenitors, a critical cell population in self-repair and homeostasis of most human tissue and organs."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Adamantine Amantadine. (PubMed, J Gen Intern Med) - "Recognition of the serendipitous history of amantadine, first as a flu treatment and now as a Parkinson disease drug, and its adamantine persistence, and how small changes, like rearranging a few letters in a word or a DNA strand, can have a big impact."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Neurostimulant Use for Rehabilitation and Recovery After Stroke: A Narrative Literature Review. (PubMed, Stroke) - "The qualitative analysis included 34 trials testing the following neurostimulants: methylphenidate (n=6), amphetamines (n=8), memantine (n=2), modafinil (n=2), levodopa (n=14), amantadine (n=1), bromocriptine (n=3), and ropinirole (n=1). In conclusion, there are promising results of positive effects of neurostimulants with few side effects, though studies are limited by heterogeneous designs and small sample sizes. Neurostimulant efficacy must be assessed in conjunction with specific rehabilitation modalities as part of larger, well-designed studies to best understand their effects on impairment."

Journal • Cardiovascular • CNS Disorders • Cognitive Disorders • Depression • Fatigue • Psychiatry

Unveiling the Uncommon: Rickettsial Infections Promoting Sudden-Onset Parkinsonism. (PubMed, Cureus) - "He was treated with a seven-day course of 100 mg doxycycline, plus a six-month course of 100 mg amantadine and 0.5 mg clonazepam, both twice daily. Additionally, these reported cases were predominantly observed in Asia, while our patient resides in the United States. This case can guide clinicians treating movement difficulties after Rickettsial infections and raise awareness of the existence of the rare etiology, treatment, and prognosis."

Journal • CNS Disorders • Developmental Disorders • Infectious Disease • Inflammation • Movement Disorders • Parkinson's Disease • Psychiatry

Cocrystallization of amantadine hydrochloride with nutrient: Insights into directed self- assembly and optimized biopharmaceutical character by integrating theory and experiment. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "Emphatically, these experimental findings are corroborated by DFT-based theoretical models, demonstrating some positive correlations between macroscopic properties and microstructures of the cocrystal. Thereby, the dual-optimization of in vivo/vitro properties of ADH allows to be fulfilled through the cocrystallization-driven strategy."

Journal

INFLUENCE OF SOCIODEMOGRAPHIC VARIABLES ON PATIENT AND PRACTITIONER KNOWLEDGE OF PHARMACOLOGICAL MANAGEMENT FOR PARKINSON'S DISEASE (ADPD 2025) - "Younger age is significantly related to higher knowledge of several PD management (aOR 0.42 -0.58) including extended - release capsules, Levodopa -Carbidopa -Entacapone tablets, Rasagiline, Safinamide, R opinirole, Pramipexole, Opicapone, Amantadine, and Trihexyphenidyl/Benzhexol. Practitioners have a statistically significant advantage in identifying most pharmacological management for PD compared to patients. Future research should investigate the quality of communication between patients with PD and practitioners to identify what might be causing this knowledge gap."

Clinical • CNS Disorders • Movement Disorders • Parkinson's Disease

Levodopa treatment: impacts and mechanisms throughout Parkinson's disease progression. (PubMed, J Neural Transm (Vienna)) - "In many patients, the LID and OFF-phases can be alleviated by modifying the levodopa therapy to provide a more continuous delivery or by using additional medications, such as monoamine oxidase-B (MAO-B) inhibitors, amantadine, or dopaminergic receptor agonists. Understanding the challenges faced by levodopa therapy also requires considering that the PD striatum is characterized not only by the loss of DA neurons but also by neuroplastic adaptations and PD-induced degenerations of other neural populations. This review provides a broad overview on the use of levodopa in treating PD, with a focus on the underlying science of the challenges encountered in late stages of the disease."

Journal • Review • CNS Disorders • Movement Disorders • Parkinson's Disease

PINK1 Parkinson's Disease in New Zealand: An Overview (P3-5.019). (PubMed, Neurology) - "The most common other treatments were apomorphine (n=7) and amantadine (n=5)...The institution of Dr. Roxburgh has received research support from Roche."

Journal • Retrospective data • CNS Disorders • Movement Disorders • Parkinson's Disease

Pharmacokinetic-pharmacodynamic Modeling of Amantadine Extended-release Capsule Effects on Dyskinesia in Parkinson Disease (P7-5.028). (PubMed, Neurology) - "Dr. Rubin has received intellectual property interests from a discovery or technology relating to health care."

Clinical • Journal • PK/PD data • CNS Disorders • Movement Disorders • Parkinson's Disease

Amantadine for Multiple Sclerosis-related Fatigue: A Systematic Review and Meta-analysis of Randomized Controlled Trials (P7-1.002). (PubMed, Neurology) - "Sarmento has nothing to disclose. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff."

Clinical • Journal • Retrospective data • Review • CNS Disorders • Fatigue • Insomnia • Multiple Sclerosis • Sleep Disorder

Efficacy and Safety of Amantadine for Functional Recovery in Adults with Traumatic Brain Injury: An Updated Systematic Review and Meta-analysis (P6-4.002). (PubMed, Neurology) - "Dr. Mazon has nothing to disclose."

Clinical • Journal • Retrospective data • Review • CNS Disorders • Epilepsy • Gastrointestinal Disorder • Vascular Neurology

Treatment of Motor Symptoms of Parkinson's Disease. (PubMed, Neurol Clin) - "Dopamine agonists, monoamine oxidase-B enzyme inhibitors, catechol-O-methyltransferase enzyme inhibitors, amantadine, istradefylline, and anticholinergics can be used as adjuncts to levodopa. With disease progression, pharmacologic interventions alone may not suffice to manage motor symptoms, making it necessary to consider device-aided therapies (eg, levodopa-carbidopa intestinal gel infusion, continuous subcutaneous infusions of apomorphine, levodopa, or foslevodopa) or invasive surgical techniques (eg, deep brain stimulation or MRI-guided high-frequency focused ultrasound)."

Journal • Review • CNS Disorders • Movement Disorders • Parkinson's Disease • COMT

Network based approach for drug target identification in early onset Parkinson's disease. (PubMed, Sci Rep) - "Notably, shared pathway analysis shows that prioritized drugs such as Amantadine, Apomorphine, Atropine, Benztropine, Biperiden, Bromocriptine, Cabergoline, Carbidopa, and Citalopram, currently used for other conditions, interact with key EOPD-associated diagnostic markers, suggesting their potential for drug repurposing. The constructed functional network's validity is reinforced by statistically significant drug-target pairs. The findings provide new insights into EOPD drug mechanisms and identify promising therapeutic candidates, potentially leading to more effective, personalized treatment approaches for EOPD patients."

Biomarker • Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • APOA1 • BDNF • PTK2B

Demise of the Milwaukee protocol for rabies. (PubMed, Clin Infect Dis) - "The protocol has included therapeutic (induced) coma, ketamine, ribavirin, and amantadine and details of the protocol have changed over time. Likely critical care, which has been used for over 50 years, is an important component of an aggressive approach. The time has now come to abandon the failed Milwaukee protocol for the therapy of rabies and consider new approaches based our current knowledge of rabies pathogenesis."

Journal • Critical care

Disorders of Consciousness and pharmacotherapy: a systematic update on drugs inducing consciousness improvement. (PubMed, Eur J Pharmacol) - "Over the last 10 years, amantadine and baclofen have proven to be the most promising treatments in terms of efficacy."

Journal • Review • CNS Disorders