amphetamine / Generic mfg. - LARVOL DELTA

Intravenous non-medical mephentermine use among young men: A consecutive case series from a tertiary addiction treatment facility in India. (PubMed, Asian J Psychiatr) - "This series highlights an emerging pattern of intravenous mephentermine misuse among young men in performance-oriented contexts. Given the associated psychosis and cardiovascular risks, clinicians should routinely screen for stimulant use. Community awareness campaigns and stricter regulation of over-the-counter stimulants are crucial for harm reduction."

Journal • Cardiovascular • CNS Disorders • Mental Retardation • Psychiatry

INFLUENCE OF COMORBIDITIES ON COLORECTAL CANCER SCREENING PARTICIPATION AND MORTALITY (DDW 2025) - "Significant comorbidity was defined as having at least one of the following: albumin10,000 copies or CD44 mg/dL, platelets4 µmol/L, NH3>20, positive urine amphetamine or cocaine, serum ethanol>80, hemoglobin A1C>10%, and stage 3 or 4 cancer...These patients also had higher all-cause mortality. Tailoring programmatic population outreach to account for significant comorbidities should improve the delivery of organized screening services."

Colorectal Cancer • Human Immunodeficiency Virus • Infectious Disease • Oncology • Solid Tumor • CD4

Plasticity of ventral tegmental area disturbance during abstinence after repeated amphetamine exposure: restoration by selective activation of group II metabotropic glutamate receptors. (PubMed, Front Pharmacol) - "The involvement VTA afferent regions with respect to AMPH actions was analyzed either by local instillation of drugs or through inactivation by tetrodotoxin. AMPH re-exposure after abstinence turned VTA activity down, but this suppression involved alternative circuits and could no longer be rescued by mGluR activation. Thus, abstinence from repeated AMPH intake drives VTA activity from hypo-into hyperdopaminergic states, and both can be readjusted towards physiological levels via different members of group II mGluRs."

Journal • Psychiatry

Successful treatment of pulmonary hypertension due to HIV infection and amphetamine snorting: a case report. (PubMed, Front Med (Lausanne)) - "In this study, we report a case of pulmonary hypertension with several concomitant risk factors who experienced a complete clinical improvement after drug rehabilitation, application of anti-retroviral therapy (ART), and sildenafil. Our case intends to raise awareness that PH should be suspected among HIV-positive patients with unexplained dyspnea. It is notable that investigating the coexistent risk factors and a multidisciplinary team are crucial for early diagnosis and better prognosis of HIV-related PH."

Journal • Cardiovascular • Hepatology • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Initial exposure to addictive drugs activates polysialylated NCAM-mediated hippocampal memory-associated synaptic plasticity in the rat prior to the emergence of dependence behaviour. (PubMed, Prog Neuropsychopharmacol Biol Psychiatry) - "Using a rodent model, we assessed hippocampal NCAM PSA expression and synaptic remodelling in response to acute and repeated administration of heroin, cocaine, and amphetamine...These results identify hippocampal memory machinery as a key early target of addictive drugs and suggest that drug-associated memories may co-opt normal learning processes, contributing to the persistent and intrusive nature of drug cravings. The study provides novel insights into the mechanisms by which early drug experiences shape enduring behavioural vulnerability to addiction."

Journal • Preclinical • CNS Disorders • Psychiatry • KLK3 • NCAM1

Effects of Repetitive Transcranial Magnetic Stimulations in Patients With Amphetamine Use Disorders (clinicaltrials.gov) - P=N/A | N=20 | Not yet recruiting | Sponsor: TsaoTun Psychiatric Center, Department of Health, Taiwan

Biomarker • New trial

Reduced Sensitivity to Negative Feedback May Lead to Risky Decision-Making in Amphetamine Users. (PubMed, Addict Biol) - "Amphetamine users were less sensitive to punitive or aversive stimuli. This reduced sensitivity might lead to a higher tendency for risky decision-making, with them less able to learn from mistakes and thus repeatedly engage in risky behaviours."

Journal

Exploring landscape of drug abuse trends in Pakistan: A decade and a half of clinical laboratory big data analysis. (PubMed, PLOS Glob Public Health) - "The panel includes screening of common drugs, amphetamine (AMP), benzodiazepine (BZO), barbiturates (BAR), cannabinoids (THC), cocaine (COC), and opioids (OPI) as well as blood alcohol (ALC) levels...Yearly trend analysis shows an increasing number of THC tests requested over time, with THC exhibiting the highest positivity rate, followed by BZO, OPI, and ALC.The 15-year patterns depict the rising prevalence of drug consumption which is subsequently increasing the demand for drug screening tests. The study highlights Pakistan's growing drug prevalence and calls for targeted policies to address its use, including strengthened prevention programs, improved regulation and better management and rehabilitation access."

Journal

Use of antidotes in cases of poisoning from drugs of abuse treated in Spanish emergency departments. (PubMed, Emergencias) - "Antidotes, usually naloxone and flumazenil, were used to treat a high percentage of patients poisoned by drugs of abuse who are attended by Spanish EDs belonging to the REDUrHE. In a third of these cases, both antidotes were used. Use was associated with diminished consciousness. Use of the antidote, especially flumazenil, was inappropriate in most of the episodes."

Journal • Anesthesia • CNS Disorders • Critical care • Epilepsy

Amphetamine Induced Group I Pulmonary Hypertension: A Case Report of Unforseen Consequences (ATS 2025) - "This abstract is funded by: None Introduction: Pulmonary hypertension (PH) is a medical condition in which there is hypertension in the lungs. In patients classified as intermediate-high risk based on their REVEAL score, PAH therapy should be initiated with endothelin receptor antagonist (bosentan), phosphodiesterase type 5 inhibitor (sildenafil), soluble guanylate cyclase stimulator (riociguat), prostanoid (epoprostenol), and/or prostacyclin agents (selexipag, and treprostinil). Treatment of PAH can be challenging as hemodynamics can be compromised with induction of these vasodilative agents; however, is necessary to prevent disease progression."

Case report • Clinical • Asthma • Cardiovascular • CNS Disorders • Congestive Heart Failure • Endocrine Disorders • Gastrointestinal Disorder • General Anxiety Disorder • Heart Failure • Hypertension • Immunology • Mood Disorders • Nephrology • Nicotine Addiction • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • Tobacco Addiction

A Fatal Case of Bupropion Overdose (ATS 2025) - "Case Report A 48-year-old woman with of past medical history anxiety, depression and alcohol use disorder presented lethargic to the emergency department (ED) for bupropion overdose after reportedly ingesting 15-20 Bupropion 300mg tablets and unknown propranolol with Vodka with a witness 45-second seizure that resolved without intervention...Initial investigation revealed bupropion level of 1436 ng/mL, elevated lactate of 4.1 mmol/L, positive amphetamine metabolites on toxicology screen and arterial blood gas consistent with metabolic acidosis...Role of VA ECMO in poison patient is with severe cardiogenic shock is still unclear and need to be studied well. Fig: EKG in the ED ."

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Constipation • Depression • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hypotension • Major Depressive Disorder • Metabolic Disorders • Mood Disorders • Pain • Psychiatry • Tobacco Cessation • Ventricular Tachycardia • Xerostomia

Low to moderate doses of 3-methylmethcathinone (3-MMC) produce analgesic effects in healthy volunteers: a proof of principle study with a designer drug. (PubMed, Psychopharmacology (Berl)) - "At present, there are no medical applications for synthetic cathinones, but in the past cathinone and other compounds that are structurally related to amphetamine have been evaluated and recognized for their intrinsic analgesic quality...It is concluded that 3-MMC produces prolonged analgesic effects at doses that appear low enough to avoid a challenging subjective experience and that have been associated with a benign side effect profile. The present data warrant further research into the analgesic effects of low to moderate doses of 3-MMC in patient populations."

Journal • Pain

Rapid Assessment of Samples from Large-Scale Clandestine Synthetic Drug Laboratories by Soft Ionization by Chemical Reaction in Transfer-High-Resolution Mass Spectrometry. (PubMed, J Am Soc Mass Spectrom) - "The aim of this work is to evaluate the suitability of the SICRIT (soft ionization by chemical reaction in transfer) ion source, which is based on the dielectric barrier discharge ionization principle, combined with high-resolution mass spectrometry (HRMS), for the rapid classification of liquid samples from amphetamine production in a seized large-scale clandestine drug laboratory...In addition, supervised machine learning algorithms were evaluated to obtain a classification model for the assessment of production waste samples from one dismantled synthetic drug laboratory, and a random forest classifier showed the best performance with an accuracy of 97%. The potential of the novel SICRIT-HRMS approach for the assessment of synthetic drug laboratories was demonstrated."

Journal

Changing age profile and incidence of injecting drug use initiation among people in Australia who inject drugs: evidence from two national repeated cross-sectional studies. (PubMed, Lancet Reg Health West Pac) - "Meth/amphetamine was consistently the predominant drug injected at initiation among IDRS participants, although there were peaks in heroin as the drug injected at initiation in the early 1980s and mid-1990s...This has implications for health service delivery to people who inject drugs, with increasing age likely to be accompanied by a rise in chronic health conditions and an increase in injecting duration potentially resulting in higher incidence of injecting-related injuries and diseases. Australian Government Department of Health and Aged Care."

Journal • Observational data

EHR Trends in First-Time ADHD Diagnoses and Amphetamine Prescriptions Across Age Groups (2021-2024) (ISPOR 2025) - "We observed increases in first-time ADHD diagnoses and amphetamine prescriptions amongst adult populations. These findings highlight the need for further research to understand the drivers behind these trends and their implications for healthcare delivery and public health."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Risks and Benefits of Prescription Stimulants in Older Adults: A Scoping Review (ISPOR 2025) - "Electronically available literature published through March 2024 that documented identifiable efficacy and/or safety outcomes related to prescription amphetamine and/or methylphenidate use among people aged ≥65 years were considered for inclusion. Many studies showed potential benefit of prescription stimulant use in older adults, however, some demonstrated potential risks. Further research is warranted to establish comprehensive guidelines for safe prescribing practices in this population."

Clinical • Review • ADHD (Impulsive Aggression) • Alzheimer's Disease • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Depression • Fatigue • Gastrointestinal Disorder • Insomnia • Mood Disorders • Movement Disorders • Narcolepsy • Oncology • Parkinson's Disease • Psychiatry • Sleep Disorder

Astroglial CB1 Reveal Sex-Specific Synaptic Effects of Amphetamine. (PubMed, Glia) - "Consistently, locomotor effects of amphetamine require astroglial CB1 receptors in male, but not female mice. These results, by revealing unforeseen mechanisms underlying sex-dependent effects of amphetamine, pave the way to a better understanding of the diverse impact of psychostimulants in women and men."

Journal

Neuropeptides and reproductive flexibility in songbirds: A mini review. (PubMed, J Neuroendocrinol) - "The well-studied pathways include gonadotropin-releasing and inhibiting hormones (GnRH, GnIH), neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART), vasoactive intestinal peptide (VIP) and other peptides like arginine vasotocin (VT), oxytocin (mesotocin), and spexin...The autumn breeding spotted munia, on the other hand, is an atypical photosensitive species. It responds to both short and long photoperiods and presumably lacks photorefractoriness."

Journal • Review

Current drug use patterns and HIV and HCV prevalence among people who inject drugs in suburban areas of Malaysia. (PubMed, J Int AIDS Soc) - "This study observed low HIV prevalence among PWID, primarily associated with ATS use, while HCV prevalence, linked to heroin use, remained high. Higher odds of being HCV positive among PWID who reported to have ever but not currently enrolled in methadone programmes indicate that treatment may not be continuous once initiated, potentially due to exposure to the criminal justice system. These findings underscore the need for a dual approach: enhanced harm reduction programmes for PWID and a legal reform to address potential barriers posed by criminalization."

Journal • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation

"Powers Unleased, Glucose Decreased: The Paradox of Superhuman Drug!" (ENDO 2025) - "Hydrocortisone was added, leading to eventual stabilization...Drugs like benzodiazepine, ecstasy, amphetamine, eutylone, cannabinoids, and cocaine have been reported in the past to be adulterated with sulfonylureas (1)(3)...Hypoglycemia after ingestion of "Street Valium" containing glyburide, alcohol, and cocaine...[10.1210/jendso/bvae163.641]*. .*"

Addiction (Opioid and Alcohol) • Brain Cancer • CNS Disorders • CNS Tumor • Diabetes • Epilepsy • Hypoglycemia • Infectious Disease • Inflammation • Meningioma • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Solid Tumor

Non-endemic Skeletal Fluorosis as a Result of Inhalant Abuse (ENDO 2025) - "History was taken by another provider a couple of years later and after further questioning the patient admitted to being addicted to amphetamine and inhaling dust cleaner almost 2-3 cans a day for 4 years, last used in 2019... History taking is a fundamental element in medicine, as always. Although there is no specific therapy for skeletal fluorosis except removing the offending agent, calcium and vitamin D deficiency seems to worsen the condition. Efforts to understand the worsening of his Z-scores include repeating fluoride as well as NTX levels to observe a trend, and re-history taking to make sure nothing else is missed."

Cardiovascular • Chronic Obstructive Pulmonary Disease • Coronary Artery Disease • Dyslipidemia • Hypertension • Immunology • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Respiratory Diseases • Thermal Injury

Characterizing Melanin-Concentrating Hormone (MCH) Neuron Subpopulations Using an Intersectional Reporter Mouse Line (ENDO 2025) - "Notably, one subset of MCH neurons exhibits an enrichment in transcripts expressing cocaine- and amphetamine-regulated transcript (Cartpt) and tachykinin receptor-3 (Tacr3)...Ultimately, this approach will enable us to identify molecularly distinct MCH subpopulations and their anatomical projections, providing important groundwork for future studies aimed at understanding the roles of these neuronal subpopulations in distinct behaviors.*. .*"

Preclinical

Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets. (PubMed, Sci Adv) - "Behaviorally, activity was elevated in a marmoset version of the amphetamine-induced activity test, and impaired probabilistic discrimination learning was seen in an OFC/striatum-dependent task that computational modeling suggests was due to loss of goal-directed behavior. Together, these findings demonstrate that a loss of primate aHipp PNNs is sufficient to induce striatal and prefrontal dysfunction consistent with that observed in humans with schizophrenia."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Synergistic Cardiotoxic Effects of Captagon and Azithromycin in Rat via Oxidative stress, Apoptosis and Upregulation of the PI3K/AKT/NF-kB pathway. (PubMed, Toxicol Lett) - "Fenethylline (Captagon) is a blend of amphetamine and theophylline that functions as a stimulant, while azithromycin (AZ) is a commonly prescribed macrolide antibiotic. Coadministration of AZ and Capta induced cardiotoxicity through oxidative stress, inflammation, and apoptosis pathways. It is important to educate healthcare providers and patients about the potential harmful interactions."

IO biomarker • Journal • Preclinical • Cardiovascular • Inflammation • BAX • BCL2 • CASP3 • CAT • IL1B • IL6 • TNFA

Infective Endocarditis in People Who Inject Drugs-A 5-Year Follow-up: "I've Seen the Needle and the Damage Done". (PubMed, Open Forum Infect Dis) - "Buprenorphine and amphetamine or other stimulant were the most used substances among PWID...Long-term survival of PWID with IE is poor, and they are at increased risk of a new IE episode as compared with non-PWID with community-acquired IE. More efforts in the treatment of addiction are needed."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Psychiatry • Substance Abuse