amphetamine / Generic mfg. - LARVOL DELTA

Preoperative illicit drug screening among elective surgery patients in West Bank, Palestine: unveiling the hidden. (PubMed, J Ethn Subst Abuse) - "Of the 224 participants who agreed to urine testing, 13.4% tested positive for at least one drug: benzodiazepines (3.6%), THC (3.1%), tramadol (2.7%), morphine (2.2%), ketamine (1.8%), and MDMA (0.4%). Cocaine, barbiturates, amphetamine, synthetic cannabinoids, and TCA tested negative in all samples...The study highlights significant discrepancies between urine screening results and self-reports, indicating high illicit drug use among surgical patients. Comprehensive preoperative screening, including interviews and urine tests, is essential for ensuring patient safety."

Journal • Anesthesia • Substance Abuse

Racial disparities in urine drug screening among seizure patients in the emergency department. (PubMed, PLoS One) - "Increased UDS testing was seen in Black patients compared to White patients in our single-institution cohort, warranting further research into the underlying causes of this disparity."

Journal • Retrospective data • CNS Disorders • Critical care • Epilepsy

AMPHETAMINE-INDUCED ACUTE EOSINOPHILIC PNEUMONIA AND ASSOCIATED PNEUMOMEDIASTINUM (CHEST 2025) - No abstract available

Infectious Disease • Pneumonia • Respiratory Diseases

Medical cannabis legalization and the use of illicit drugs, alcohol, and tobacco. (PubMed, J Cannabis Res) - "It explores associations between MC sales, and variables including tobacco use, alcohol consumption, amphetamine, cocaine and cannabis prevalence, and gross domestic product (GDP), using a fixed effects (FE) panel regression model...Nonetheless, they highlight the potential economic relevance of cannabis legalization in expanding regulated markets and reshaping consumer behavior. The study contributes to debates on legalization, public health, and economic policy by providing empirical evidence on the associations between legal reforms and market dynamics."

Journal

Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism. (PubMed, Sci Signal) - "The magnitude of amphetamine-induced NVDR was partially mediated by an increase in DAT abundance stimulated at a transcriptional level, and the administration of F. nucleatum or butyrate enhanced NVDR by increasing DAT expression. The findings indicate that F. nucleatum supports AUD through epigenetic regulation of dopamine signaling and identify potential targets for AUD treatment."

Journal • CNS Disorders • Mental Retardation • Psychiatry • HDAC1

Intraday trends of chemical biomarkers in wastewater monitored through automated real-time surveillance. (PubMed, Water Res) - "Population biomarkers exhibited distinct temporal profiles: paraxanthine remained stable during working hours, while candesartan declined even at peak population times - highlighting implications for normalization, particularly with day visitors...During the special events, MDMA, ketamine, and amphetamine loads rose with distinct profiles - one event showing a gradual overnight rise, the other a morning peak...Levamisole loads rose on weekends and during events, mirroring benzoylecgonine, indicating continued presence as harmful cocaine adulterant. Automated analysis reveals short-term intraday trends, providing additional insights into the sources of chemical marker loads - such as consumption, excretion, and contributions from transient populations - that are typically averaged out in standard 24-hour composite samples."

Biomarker • Journal

Assessing TDApp: An AI-based clinical decision support system for ADHD treatment recommendations. (PubMed, Front Psychiatry) - "TDApp evaluated over 10 drugs, including recently marketed ones, with amphetamine derivatives emerging as the most frequently recommended interventions...TDApp is an advanced prototype of an CDSS offering automated, participatory, personalized, and explanatory treatment recommendations for ADHD. It represents a promising alternative to CPGs for aiding clinicians and patients in shared treatment decision-making."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Pediatrics • Psychiatry • NBN

mGlu2 Receptors in the Basal Ganglia: A New Frontier in Addiction Therapy. (PubMed, Front Biosci (Landmark Ed)) - "Here, we highlight that recent progress in mGlu2 biology research demonstrates the pivotal roles of mGlu2 receptors in different aspects of drug addiction. mGlu2 subtype-selective agents (both orthosteric and allosteric compounds) thus have the potential to be developed into novel pharmacotherapies for addictive conditions."

Journal • Review • Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry • Substance Abuse

Mussel-inspired polydopamine-functionalized ultralight cellulose aerogel for simple and portable extraction of synthetic cathinones from biological samples. (PubMed, J Chromatogr A) - "Their greater accessibility compared with the traditional amphetamine-type stimulants has contributed to their increasing popularity in recent years...After eight consecutive cycles, the aerogel retained over 84 % of its initial extraction performance. Therefore, this green and sustainable aerogel shows strong potential for applications in forensic toxicology."

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Thoracic surgical confirmation of histoplasmosis after kidney transplantation (NTX) (DGT 2025) - "This was confirmed microbiologically, and treatment with isosomal amphetamine B was initiated... Histoplasmosis infection must be considered if pulmonary melting or abscesses are found in organ recipients and if they have previously resided in areas affected by histoplasmosis. Due to the high mortality from hematogenous spread in immunosuppressed patients, antifungal therapy with amphotericin B, or less frequently voriconazole, is required."

Fatigue • Hematological Disorders • Infectious Disease • Nephrology • Septic Shock • Transplantation

Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization. (PubMed, Mol Psychiatry) - "Interestingly, reduction of membrane cholesterol selectively increased amphetamine-induced efflux via SERT, while efflux via DAT and NET was reduced...Hence, the increased efflux at SERT due to cholesterol depletion appears to depend on the ability of PIP2 to bind to SERT. Thus, we hypothesize that the interaction profile between cholesterol and MATs may fine-tune the transporter functionality and influence MAT-dependent disorders."

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Computational Evaluation of the Use of Fluorescein Isothiocyanate as a Preliminary Test for Amphetamines and Cathinones. (PubMed, ACS Omega) - "Forty-two amphetamine-type stimulants were examined using density functional theory (DFT) and UV-vis spectra via TD-DFT...Hence, FITC-based tests might be useful as part of a series of presumptive assays but are not suitable as a sole method. Furthermore, the study highlights how in silico methods can effectively evaluate new reagents for forensic purposes, providing faster and more cost-efficient alternatives to experimental testing."

Journal

Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids. (PubMed, European J Org Chem) - "Ibogaine has been shown to reduce opiate, amphetamine, alcohol, and nicotine self-administration in rodents...While there have been over twenty total syntheses of ibogamine, ibogaine, and closely related family members, there are far fewer syntheses of recently isolated iboga alkaloids. In this targeted review, we discuss the synthetic strategies applied to the synthesis of classical and non-classical iboga alkaloids."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • Substance Abuse

Stimulant Medications and Sleepiness in ADHD: Insights from a Sleep Deprivation Study (WSS 2025) - "Stimulant medications, such as Methylphenidate and Amphetamine, effectively mitigate excessive sleepiness experienced by young men diagnosed with ADHD, even under conditions of extended sleep deprivation. These findings have important clinical and theoretical implications. Given the negative effects of sleepiness on cognition and emotional regulation, these results suggest that the beneficial effects of stimulant medications in ADHD may partially stem from their effect on sleepiness."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry • Sleep Disorder

Treatment Considerations in Co-morbid Schizophrenia and Narcolepsy: A Case Report (WSS 2025) - "Some alertness promoting medications used in narcolepsy treatment, such as modafinil, methylphenidate and amphetamine, may exacerbate psychosis by increasing dopamine activity...He was previously intolerant to modafinil (emotional numbing) and Concerta (appetite suppression) as per chart review.Paliperidone was effective for psychosis but worsened sleepiness, which was disabling... In conclusion, some traditional stimulants may worsen psychosis in PWN. Pitolisant, an inverse H3 agonist, which does not theoretically affect dopamine pathways, may be a suitable treatment for sleepiness and cataplexy in comorbid psychosis."

Case report • Clinical • Cataplexy • CNS Disorders • Narcolepsy • Psychiatry • Schizophrenia • Sleep Disorder

Evidence of Nose-To-Brain Delivery of Lithium: Implications for Mood Disorders and Beyond (WFSBP 2025) - "(3) in vivo rat model showed that intranasal lithium delivery produced same behavioural response than intraperitoneal lithium delivery in an amphetamine model of mania... This study provides the first evidence of successful nose-to-brain delivery of lithium using nanoparticle network hydrogels. The results also suggest that intranasal lithium can exert significant behavioural changes with significantly less circulating serum levels. These results have important implications for translational research in mood disorders, given the need for long-term treatments with potential for systemic side effects."

Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Diagnostic Changes in Amphetamine-Induced Psychotic Disorder: A Retrospective Study (WFSBP 2025) - "A substantial proportion of patients with AIPD experience diagnostic changes over time. Several hospitalizations and antipsychotic use are significant predictors of diagnostic changes. These findings highlight the dynamic nature of amphetamine-induced psychosis and emphasize the need for careful longitudinal assessment and flexible treatment approaches."

Retrospective data • Bipolar Disorder • CNS Disorders • Mental Retardation • Mood Disorders • Personality Disorder • Psychiatry • Schizophrenia

A Rare Presentation of Gastric Ischemia Manifesting as Gastric Pneumatosis in the Context of Amphetamine Use (ACG 2025) - "A nasogastric tube was placed for decompression, and the patient was started on ceftriaxone and metronidazole. Our case highlights the need to consider gastric ischemia in patients with amphetamine use disorder presenting with nonspecific gastrointestinal symptoms and imaging suggestive of gastric pneumatosis. Early recognition of gastric pneumatosis is crucial to improve patient outcomes, as it may indicate ischemia and carries a risk of increased mortality.Figure: Axial computed tomography image of the abdomen demonstrating gastric pneumatosis, indicated by red arrows."

Cardiovascular • Gastrointestinal Disorder • Hypotension • Infectious Disease • Ischemic stroke

Beyond Varices: Left Gastric Pseudoaneurysm as a Rare Cause of Upper GI Bleed in Cirrhosis (ACG 2025) - "Several interventions, including hemostasis powders, epinephrine, and ethanolamine, were unsuccessful, so a fully-covered stent was placed to tamponade the bleed. It is possible that the pseudoaneurysm developed due to severe local inflammation from the amphetamine-induced esophagitis. Worsening esophagitis and coagulopathy likely caused the pseudoaneurysm to rupture, resulting in a bleed refractory to endoscopic intervention and requiring embolization.Figure: Figure 1: CT Angiography Demonstrating the Pseudoaneurysm in the Gastroesophageal Branch of the Left Gastric Artery"

Atherosclerosis • Cardiovascular • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatitis B • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Mood Disorders • Pancreatitis • Varicose Veins

In brief: New warning for extended-release stimulants for ADHD. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Assessment of risk factors associated with methadone-induced deaths: A population study based on forensic autopsies (2003-2022). (PubMed, Forensic Sci Int) - "This forensic study reveals that poly-drug use is a major contributor to methadone-related fatalities. Concomitant use of methadone with benzodiazepines or psychostimulants is particularly hazardous. Pharmacological interactions must be carefully assessed in methadone users. Our findings underscore the value of forensic data in identifying lethal drug combinations and supporting safer prescribing practices and public health strategies."

Journal

Gold-Containing Compound Auranofin Ameliorates 6-OHDA Induced Neurotoxicity in Rats: Via Targeting PI3K/Akt/GSK-3β Signalling. (PubMed, Clin Exp Pharmacol Physiol) - "After performing the amphetamine challenge test, rodents were treated with AUF (10 mg/kg) and AUFHNPs (5 and 10 mg/kg) for 21 days...It also restored morphological changes and increased expression of pPI3K/pAKT, followed by inhibition of GSK-3β. Thus, the AUFHNPs were more significant than AUF alone and exerted neuroprotection via modulation of PI3K/AKT/GSK-3β signalling pathways."

Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease • GSK3B

Global burden of disease due to opioid, amphetamine, cocaine, and cannabis use disorders, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. (PubMed, PLoS One) - "Sex and geographical variations were notable, with males and world regions like high-income North America, Australasia, and Eastern/Western Europe showing disproportionately higher rates. Overall, these findings highlight rising mortality and morbidity rates despite a modest decline in incidence, underscoring the need for tailored public health interventions, advancing harm reduction programs, and expanding access to treatment."

HEOR • Journal • Addiction (Opioid and Alcohol) • Substance Abuse

A novel cost-benefit decision-making task involving cued punishment; effects of sex and psychostimulant administration. (PubMed, Behav Brain Res) - "Similar to acute amphetamine, acute systemic administration of the D2/3 dopamine receptor agonist bromocriptine reduced preference for the large reward across all groups. These findings highlight the contributions of punishment cues to decision making, as well as the importance of sex as a biological variable in investigating cognitive alterations caused by chronic substance use."

HEOR • Journal

From garden to product: Scientific strategies for identity verification of botanical constituents (ACS-Fall 2025) - "For example, 1,3-dimethylamylamine (1,3-DMAA), an amphetamine derivative,was purported to be present in certain geranium plants, such as Pelargonium graveolens...In this poster, we will discuss some factors toconsider when verifying that a chemical compound is a constituent of a botanical and present some best practices to address these factors. Case examples will be provided to illustrate the intricacies surrounding chemical characterization of complex botanical mixtures."