amphetamine / Generic mfg. - LARVOL DELTA

Evaluation of forensic toxicological characteristics of cases under the age of eighteen with substance use: a sample from Türkiye. (PubMed, Turk J Pediatr) - "This study assessed substance use profiles in adolescent populations through substance testing. ATS were the most frequently detected substances. The analysis revealed a significant increase in the proportion of female cases over time. While cannabis use was more prevalent among males, ATS use was more common among females. Collecting objective, valid, and definitive data will facilitate the identification of substance use issues and support the development of effective preventive policies."

Journal • Retrospective data • Pediatrics • Substance Abuse

Non-endemic Skeletal Fluorosis as a Result of Inhalant Abuse (ENDO 2025) - "History was taken by another provider a couple of years later and after further questioning the patient admitted to being addicted to amphetamine and inhaling dust cleaner almost 2-3 cans a day for 4 years, last used in 2019... History taking is a fundamental element in medicine, as always. Although there is no specific therapy for skeletal fluorosis except removing the offending agent, calcium and vitamin D deficiency seems to worsen the condition. Efforts to understand the worsening of his Z-scores include repeating fluoride as well as NTX levels to observe a trend, and re-history taking to make sure nothing else is missed."

Cardiovascular • Chronic Obstructive Pulmonary Disease • Coronary Artery Disease • Dyslipidemia • Hypertension • Immunology • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Respiratory Diseases • Thermal Injury

"Powers Unleased, Glucose Decreased: The Paradox of Superhuman Drug!" (ENDO 2025) - "Hydrocortisone was added, leading to eventual stabilization...Drugs like benzodiazepine, ecstasy, amphetamine, eutylone, cannabinoids, and cocaine have been reported in the past to be adulterated with sulfonylureas (1)(3)...Our patient had refractory hypoglycemia, was positive for PCP, and had very high urine glipizide levels confirming the diagnosis. It's important to rule out drug adulteration with sulfonylurea as a potential cause and treat it appropriately with dextrose and octreotide."

Addiction (Opioid and Alcohol) • Brain Cancer • CNS Disorders • CNS Tumor • Diabetes • Epilepsy • Hypoglycemia • Infectious Disease • Meningioma • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Solid Tumor

Characterizing Melanin-Concentrating Hormone (MCH) Neuron Subpopulations Using an Intersectional Reporter Mouse Line (ENDO 2025) - "Notably, one subset of MCH neurons exhibits an enrichment in transcripts expressing cocaine- and amphetamine-regulated transcript (Cartpt) and tachykinin receptor-3 (Tacr3)...We then identified unique anatomical projection targets of labeled MCH(Tacr3+) neurons within the forebrain and midbrain. Ultimately, this approach will enable us to identify molecularly distinct MCH subpopulations and their anatomical projections, providing important groundwork for future studies aimed at understanding the roles of these neuronal subpopulations in distinct behaviors."

Preclinical

Amphetamine and Nicotine Reduce Sucrose Self-Administration Independent of Sex. (PubMed, bioRxiv) - "The effects of both amphetamine and nicotine did not differ by sex for either drug. Overall, these results suggest that the mechanisms mediating the addictive qualities of these drugs and their appetite suppressing effects may be distinct and therefore could be a potential target for future obesity therapeutics."

Journal • Genetic Disorders • Obesity

Navigating the challenges of substance use and psychopathology in depression, bipolar disorder, and schizophrenia. (PubMed, Compr Psychiatry) - "Overall, most manuscripts recording SUDs concerned the following drugs: alcohol (N = 26), cannabis (N = 19), opioids (N = 10), cocaine (N = 10), and amphetamine (N = 3), while several studies described SUDs in general (N = 12)...In the case of psychotic symptoms and SUDs, aripiprazole appeared to be the most used medication in the maintenance therapy not only for its effectiveness but also for its safety profile. Alternatively, despite the side effects, clozapine showed a good efficacy in the management of symptoms and in terms of relapse prevention...With regard to the treatment of MDD/BD and SUDs, there are mixed findings regarding the best medication for symptom control; notably, different degrees of efficacy were recorded if added to psychological/behavioural interventions, or combined with specific SUD treatments, such as opioid receptor agonist/antagonist therapies or the anti-glutamatergic drugs..."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • Schizophrenia

Prefrontal and ventral striatal dendritic morphology: effects of life-long complex housing and amphetamine administration. (PubMed, Behav Brain Res) - "Thus, both complex housing and amphetamine can produce a range of synaptic changes depending upon sex and area examined. Furthermore, the effect of complex housing varies depending on the details of when complex housing is begun and how long it lasts."

Journal

Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice. (PubMed, Behav Brain Funct) - "This study finds that BMAL1 ablation in dopaminergic neurons induces ADHD-like phenotypes in male mice, identifying hyperactive dopamine signaling as a potential mediator of these phenotypes. It unveils a novel role for BMAL1 in regulating dopamine signaling and provide insights into circadian gene-driven psychiatric pathophysiology."

Journal • Preclinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mental Retardation • Psychiatry • ARNTL • BMAL1

Fatal Outcome of Suicidal Multi-Substance Ingestion Involving Sodium Nitrate and Nitrite Toxicity: A Case Report and Literature Review. (PubMed, Acta Med Litu) - "Toxicology results confirmed a blood alcohol concentration of 1.22‰, with trace levels of amphetamine, atropine, and quetiapine, while nitrites detected in the gastric contents confirmed sodium nitrite as a primary toxic agent. Due to the inherent instability of nitrite in blood, its post-mortem detection is often challenging, thereby complicating toxicological confirmation. The increasing accessibility and misuse of sodium nitrite underscore an urgent need for regulatory oversight, public awareness, and enhanced preventive measures to address the rising incidence of intentional sodium nitrite toxicity, particularly within at-risk populations."

Journal • Addiction (Opioid and Alcohol) • Hematological Disorders

COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT (CART) PEPTIDE MEDIATES INTRACELLULAR CA2+ RELEASE IN SENSORY NEURONS AND INDUCES FIRING OF THE COLON-INNERVATING LUMBAR SPLANCHNIC NERVE (UEGW 2025) - No abstract available

Fatalities following DMT use: Two case reports and a review of the literature. (PubMed, J Anal Toxicol) - "There have been two recent deaths following DMT use in the UK, both in the context of polydrug use which may have caused death due to excessive serotonergic innervation leading to serotonin syndrome. Polydrug use is increasingly common in the UK, and users of unregulated drugs should caution their use in combination with other unregulated drugs and also any prescribed medications."

Journal • CNS Disorders

Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance. (PubMed, Addict Biol) - "Previous reports indicate that trace conditioning, where drug administration occurs after removal from the conditioning chamber, results in CPA to ethanol, nicotine and amphetamine...This approach revealed a subset of subjects sensitive to the aversive state immediately following cocaine administration. Our findings suggest that striatal dynorphin has opposing roles in mediating the aversion associated with acute cocaine intoxication versus cocaine withdrawal."

Journal • Mood Disorders • Psychiatry • PENK

Visualization of the existence of LEAP2 in the nucleus accumbens and its role in amphetamine-induced locomotor activity. (PubMed, Mol Brain) - "However, its inhibitory effects were absent following chronic AMPH exposure, indicating that the effect of LEAP2 on AMPH-induced locomotor activity varies depending on drug-exposed physiological status. These results provide new insights into a state-dependent regulatory role of LEAP2 in AMPH-induced locomotor activity."

Journal

Global and regional burden of four drug use disorders in the elderly, 1990 to 2021: an analysis of the global burden of disease study. (PubMed, BMC Geriatr) - "The burden of DUDs among the elderly varies across countries, regions, SDI levels, and genders, underscoring the need for targeted public health policy adjustments and strategic allocation of medical resources to mitigate this burden."

HEOR • Journal • Geriatric Disorders • Substance Abuse

Neurochemical alterations in monoaminergic systems induced by excessive sucrose consumption from the juvenile period to adolescence in mice. (PubMed, Neurosci Lett) - "Response to amphetamine (AMP) treatment was determined using the open-field test...Excessive SUC and SAC consumption during the critical developmental window induces region-specific alterations in DA and 5-HT metabolism, suggesting distinct neural effects of caloric vs. noncaloric sweeteners. These findings emphasize the need for further research on their long-term neurodevelopmental consequences."

Journal • Preclinical • CNS Disorders • Mental Retardation • Oncology • Psychiatry

The Effect of Dual Diagnosis of Substance Use Disorders on Circadian Rhythm and Sleep Quality in Patients with Bipolar Disorder. (PubMed, Noro Psikiyatr Ars) - "In addition, further comparisons were made by dividing Group 2 according to dominant substance use as alcohol, cannabis and other (amphetamine, opiate) Sleep (p=0.011) and social subscale values (p<0.001) from the BRIAN subscales of Group 1 were lower than in the cannabis group...It was determined that dual diagnosis of SUD negatively affected sleep quality, increased daytime sleepiness and caused deterioration in circadian rhythm, and there was no significant change in chronotype preference in patients with BD. In addition, in patients accompanied by cannabis use; it was determined that there was a greater deterioration in biological rhythm and sleep quality."

Journal • Addiction (Opioid and Alcohol) • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

AMPHETAMINE-INDUCED ACUTE EOSINOPHILIC PNEUMONIA AND ASSOCIATED PNEUMOMEDIASTINUM (CHEST 2025) - No abstract available

Infectious Disease • Pneumonia • Respiratory Diseases

Stimulant Use in Adolescent ADHD is Associated with Attenuated and Distinct Cortical Differences (OHBM 2025) - "Stimulant medications (i.e., amphetamine and methylphenidate) appear to normalize ADHD-related differences in surface area and volume among 9- and 10-year-olds. Additionally, stimulant use was associated with differences in cortical thickness and cortical volume within brain regions that did not exhibit significant ADHD-status differences, suggesting broader neurodevelopmental impacts beyond ADHD-specific phenotypes. In contrast, nonstimulant medication use was not associated with significant alterations in brain MRI phenotypes."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Neuroprotective potential of novel CARTp analogs in the hippocampus of THY-Tau22 mouse model of Tau pathology. (PubMed, Neuropharmacology) - "One of the strong anorexigenic neuropeptides is called cocaine- and amphetamine-regulated transcript peptide (CARTp), which is the third most abundant transcript in the hypothalamus...Furthermore, treatment with CARTp analogs showed increased levels of synaptic markers in the hippocampus. A beneficial effect on these attributes makes CARTp analogs promising for AD therapy."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Inflammation • GFAP

Illegal drugs sensor: Performance evaluation and identification based on terahertz photonic crystal fiber. (PubMed, PLoS One) - "Three illegal drugs - ketamine, amphetamine, and cocaine - have been simulated for the sensor. These modifications have an impact on how light travels within the fiber. Drug molecules interact with light as a result of changes in the optical properties of the core that occur during light propagation through it."

Journal • CNS Disorders • Sleep Disorder

Magnetic Molecularly Imprinted Polymers for Extraction of Four Amphetamine-Type Stimulants From Sewage and Urine. (PubMed, J Sep Sci) - "Successful application to real sewage and urine samples confirmed robust matrix interference resistance and reliability (recoveries: 82.1%-116%, RSD < 6.4%). This study provides a sensitive, reusable, and environmentally friendly approach for monitoring ATSs in environmental and forensic matrices."

Journal

Cocaine-induced immediate-early gene expression in the nucleus accumbens: roles of separate cAMP sensors. (PubMed, bioRxiv) - "Immediate-early gene (IEG) induction after administration of amphetamine or cocaine has been used to trace the signaling pathways that mediate neuronal plasticity required for the short- and long-term behavioral effects of these psychostimulants...Thus, acute or chronic cocaine administration activates at least two cAMP-dependent signaling pathways in D1-MSNs: a PKA-Fos pathway and a RapGEF2-ERK-Egr-1 pathway. The finding that PKA also activates the ERK-Egr-1 signaling pathway by convergence on Rap1, and concomitantly activates c-Fos independently of Rap1, may underlie selective effects of metabotropic activation of RapGEF2 and PKA activation by cAMP on cocaine-dependent behaviors in mice."

Journal • FOS • PDE4D • RAP1A

In-syringe polypropylene fiber-supported liquid microextraction using natural deep eutectic solvents for the convenient analysis of amphetamine-type stimulants in biological and environmental samples. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Relative recoveries ranged from 81.8% to 104.8%, with relative standard deviations below 10.6%. The method's performance was successfully demonstrated in both environmental and biological sample analyses, providing a rapid, cost-effective, sensitive, and sustainable solution for ATS detection."

Journal

Chemical coding of piglets small intestine neurons after prenatal exposure to β-hydroxy-β-methylbutyrate. (PubMed, J Vet Res) - "Tissue sections were fixed in paraffin, reacted with anti-vasoactive intestinal peptide (VIP), anti-cocaine- and-amphetamine-regulated transcript (CART), anti-neuronal nitric oxide synthase (nNOS) and anti-substance P (SP) antibodies, and the immunoexpression of VIP, CART, nNOS and SP was determined histomorphometrically by calculating the area of fibres which were immunoreactive with each. Supplementation with HMB in sows caused significant changes in the ENS of newborn piglets, including an increase in the area of fibres reactive to CART and nNOS in certain layers and sections of the small intestine, and a decrease in the area of fibres reactive to SP and VIP. The results indicate that prenatal supplementation with HMB in sows may significantly influence the functioning of the gastrointestinal tract in newborn piglets."

Journal • Gastrointestinal Disorder

Pathway-specific regulation of amphetamine-induced conditioned place preference by chemogenetic modulation of basolateral amygdala projections to prelimbic cortex and nucleus accumbens subregions. (PubMed, Neurochem Int) - "In contrast, BLA-to-NAc core manipulations selectively modulated locomotor aspects of conditioned responses without affecting place preference, while BLA-to-NAc shell manipulations produced no significant effects on CPP expression. These results demonstrate that the BLA has a distinctive pathway-specific roles in the expression of contextual drug memory."

Journal