arotinolol / Generic mfg. - LARVOL DELTA

PRECISE: Protecting Renal Function in Chronic Kidney Disease Patients with Isolated Nighttime Hypertension (clinicaltrials.gov) - P=N/A | N=200 | Not yet recruiting | Sponsor: Shanghai Institute of Hypertension

New trial • Cardiovascular • Chronic Kidney Disease • Hypertension • Nephrology • Renal Disease

Medication status and related factors in essential tremor patients: a cross-sectional study in China. (PubMed, Neuroepidemiology) - "The proportion of medication intake is low among both all ET patients and recommended medication users. The top two commonly used medications among all ET patients are arotinolol and propranolol. Influencing factors of medication intake are different between all ET patients and recommended medication users. Clinicians are suggested to provide counseling and education on ET medication to promote medication intake."

Journal • Observational data • Essential Tremor • Movement Disorders

Drugs Used to Treat Essential Tremors (PubMed, Brain Nerve) - "Arotinolol is the first treatment of choice because it is the only drug developed in Japan approved for treating essential tremors. If sympathomimetic agents are unavailable or ineffective, a change to primidone, or a combination of both, should be considered. Benzodiazepines and other anti-epileptic drugs should also be administered."

Journal • Epilepsy • Essential Tremor • Movement Disorders

Effect of arotinolol on chronic heart failure: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Front Cardiovasc Med) - "More high-quality randomized controlled trials are needed for further verification, to provide a more scientific basis for the safety and effectiveness of arotinolol in the clinical treatment of heart failure. [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=371214], identifier [CRD:420223371214]."

Retrospective data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • CRP

Impact of a synchronous prophylactic treatment of the anterior accessory saphenous vein on the recurrent varicose vein rate in patients undergoing thermal ablation of an insufficient great saphenous vein (SYNCHRONOUS-Study): study protocol for a prospective, multicentre, controlled observational study. (PubMed, BMJ Open) - "Before initiation of the study, the protocol was presented and approved by the independent ethics committee of the medical faculty of the University of Heidelberg (Ethics approval number S-596/2018)...Research findings will be disseminated in a peer-reviewed journal and at relevant conferences. German Clinical Trial Registry (DRKS00015486)."

Journal • Observational data • Dermatology • Pain • Varicose Veins

Enantioseparation of β-receptor blockers and the enantioselective degradation of carvedilol in soil. (PubMed, J Pharm Biomed Anal) - "Enantioseparation of seven β-receptor blockers, including carvedilol, metoprolol, atenolol, sotalol, propafenone, bisoprolol and arotinolol was investigated using HPLC coupled with pre-column derivatization in this work. The degradation of carvedilol enantiomers in soil at natural condition conformed to the first-order degradation kinetics (R > 0.9790). The half-lives of carvedilol enantiomers were 17.77 and 16.90 days, respectively and the enantiomer fraction (EF) values of carvedilol enantiomers ranged from 0.488 to 0.523 with time in soil, indicating the degradation behaviors, disposition and biotransformation of carvedilol enantiomers in soil showed no enantioselectivity (P > 0.05)."

Journal • Mental Retardation

Essential Tremor That is Difficult to Improve with Standard Medical Treatment-Suppression: Excluding Surgical Treatment (PubMed, Brain Nerve) - "In Japan, medical treatment is based on the use of arotinolol and primidone, and combination therapy and second-line drugs are extensively discussed. Furthermore, an algorithm of the treatment for essential tremors in Japan has been provided."

Journal • Essential Tremor • Movement Disorders

Mechanism of bicarbonate enhancing the photodegradation of β-blockers in natural waters. (PubMed, Water Res) - "The results show that in the presence of HCO, the photodegradation rates increase significantly for sotalol (SOT), whereas no effects on the degradation of carvedilol and arotinolol are observed. In addition, the results show that seawater DOM could increase HCO-induced photodegradation of SOT, whereas SRNOM mainly behaves as a CO quencher and decreases the removal rate of SOT. The results underscore the role of HCO in limiting the persistence of organic pollutants like SOT in sunlit natural waters, and especially in marine and coastal waters."

Journal

Preparation and evaluation of an ethylenediamine dicarboxyethyl diamido-bridged bis(β-cyclodextrin)-bonded chiral stationary phase for high performance liquid chromatography. (PubMed, J Chromatogr A) - "Moreover, EBCDP was able to utilize the complexation of the bridging linker (ethylenediamine dicarboxyethyl diamide group, EDTA-based) to realize direct separations of DL-amino acids with a mobile phase containing copper ion (Cu), which was similar to the chiral ligand exchange chromatography. Unlike the native cyclodextrin with small cavity (~242 Å), the bridged bis(β-CD) combined two β-CD units with a bridging linker, having a well-organized "pseudo-cavity" as an organic whole to encapsulate more analytes, which made EBCDP have broad-spectrum applications in chiral separations."

Journal

AHOCEP: Effect of Arotinolol Hydrochloride on Cardiovascular Events in Hypertensive Haemodialysis Patients (clinicaltrials.gov) - P4; N=300; Completed; Sponsor: Sumitomo Pharmaceutical (Suzhou) Co., Ltd.; Active, not recruiting ➔ Completed; Trial primary completion date: Sep 2017 ➔ Oct 2018

Clinical • Trial completion • Trial primary completion date

ESAHOM: Efficacy and Safety of Arotinolol Hydrochloride on Morning Blood Pressure and Heart Rate (clinicaltrials.gov) - P4; N=198; Completed; Sponsor: Sumitomo Pharmaceutical (Suzhou) Co., Ltd.; Recruiting ➔ Completed

Clinical • Trial completion