aspirin/glycine / Generic mfg. - LARVOL DELTA

Branch Retinal Artery Occlusion as a Presentation of Seronegative Antiphospholipid Syndrome in Pregnancy. (PubMed, Cureus) - "A multidisciplinary team monitored her pregnancy, and she was started on subcutaneous enoxaparin 40 mg twice a day and oral aspirin/glycine 100 mg/45 mg once daily. This case highlights the importance of recognizing BRAO as it can be the presentation of a previously unrecognized seronegative antiphospholipid syndrome. Early recognition of the correct diagnosis is vital to allow effective multidisciplinary management, especially when dealing with a patient in pregnancy."

Journal • Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Obstetrics • Ophthalmology • Rheumatology • Thrombosis

Pharmacokinetics of aspirin: evaluating shortcomings in the literature. (PubMed, Expert Opin Drug Metab Toxicol) - "Furthermore, previous pharmacokinetic studies did not consider the contribution of other substrates from the diet or genetic variants, to the detoxification rate of glycine conjugation. Impaired glycine conjugation might contribute to adverse health effects seen in Reye's syndrome and cancer."

Journal • PK/PD data • Review • Oncology • Pain

Infrequent Aspirin Use Among Lynch Syndrome Patients in a Nationally Representative Database in the United States (CGA-IGC 2023) - "Although Aspirin use has doubled in LS patients from 2012-2023, overall usage still remains low and presents a CRC prevention opportunity for LS patients in the US. Future work will be needed to examine patient-, provider- and system-level predictors of Aspirin use to target interventions to improve use."

Clinical

Combination of Photothermal Therapy with Anti-Inflammation Therapy Attenuates the Inflammation Tumor Microenvironment and Weakens Immunosuppression for Enhancement Antitumor Treatment. (PubMed, Small) - "TTM NPs based photothermal therapy are combined with Aspisol, a kind of nonsteroidal anti-inflammatory drug, to weaken the inflammation and immunosuppression tumor microenvironment and enhance the antitumor effect...The data show that combination therapy can suppress the expression of inflammatory factors, enhance dendritic cell activation and maturation, reverse the immunosuppression, facilitate T cell infiltration, and restore antitumor cytotoxic T lymphocyte activity. This study provides a paradigm to extend the development of photothermal therapy."

Biomarker • Journal • Tumor microenvironment • Immunology • Inflammation • Oncology

Aspirin May Help Preserve Brain Function in Older Women With Heart Disease [Google translation] - "Aspirin may help prevent strokes, and sometimes a series of 'mini strokes' can lead to cognitive decline and even lead to dementia, said Dr. Deepak Bhatt...Not everyone can or should take aspirin, Bhatt noted."

Media quote