azelaic acid gel / Generic mfg. - LARVOL DELTA

Efficacy and Safety of Azelaic Acid and Azelaic Acid Combined with Compound Acid in the Treatment of Post-Inflammatory Erythema and Pigmentation of Acne: A Single-center, Prospective, Randomized Controlled Clinical Study Protocol (ChiCTR) - P=N/A | N=64 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New trial • Acne Vulgaris • Dermatology

Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris (EADV 2024) - "The results indicate that 15% AzA gel effectively improved acne-induced PIE and PIH with minimal adverse reactions, making it a viable clinical application. In the study population, it had no adverse effects on skin barrier function and contributed positively to acne improvement and patient quality of life."

Acne Vulgaris • Dermatology

Evaluation of a cosmetic foam containing 15% azelaic acid for mild to moderate acne in Chinese patients (EADV 2024) - "We developed an azelaic acid foam specifically for this population... The efficacy results after 4 weeks suggest a stable and continuous activity of the product in reducing the severity of acne, promoting the regression of the inflammatory papules, and improving barrier function. Figure 1 Table 1 W0 W2 W4 skin hydration (%) 48.98±11.72 52.06±8.64 58.64±8.56* TEWL (g/hm2) 27.07±7.73 23.27±6.28* 23.09±7.06* casual sebum (μ g/cm2) 148.44±51.38 140.44±49.24 118.59±44.81* Table 2 W0 W2 W4 Sensitivity Skin tightness intensity 2.55 2.07 -18.90% ↓ Skin tightness frequency 2.32 1.80 -22.50% ↓ Skin turgor 0.35 0.20 -43.64% ↓ Skin scale 0.45 0.33 -26.19% ↓ Skin redness 0.42 0.33 -20.51% ↓ Overall healthy 1.45 1.63 12.52% ↑ Skin texture Coarse pore 1.94 1.73 -10.44% ↓ Skin oiliness 1.90 1.53 -19.44% ↓ Comedones Comedo number 1.74 1.50 -13.89% ↓ Comedo area 1.45 1.33 -8.15% ↓ Comedo extent 1.58 1.47 -7.21% ↓ Comedo size 1.26 1.20 -4.62% ↓..."

Clinical • Acne Vulgaris • Pruritus

Evaluation of the effects of 5% and 10% azelaic acid foam on sebum and acne lesions in Chinese acne patients (EADV 2024) - "This study demonstrated excellent efficacy of both concentrations of azelaic acid foam in reducing sebum secretion and the number and area of comedone lesions. 10% azelaic acid foam is more suitable for acne patients with oily skin. Figure 1 Figure 2 Table 1 Before testing (D0) D3 D7 D28 5% azelaic acid foam 6.17 5.97 5.43* 4.63* Percentage reduction / 3.24% 11.89% 24.86% 10% azelaic acid foam 6.93 6.57* 5.97* 5.10* Percentage reduction / 5.19% 13.85% 26.41%"

Clinical • Acne Vulgaris

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (clinicaltrials.gov) - P1 | N=15 | Recruiting | Sponsor: Wake Forest University Health Sciences | Not yet recruiting ➔ Recruiting

Enrollment open • Alopecia • Dermatology • Immunology

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2024 ➔ Jun 2025 | Trial primary completion date: Dec 2024 ➔ Jun 2025

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

Combination treatment on clinical improvement in rosacea patients (EADV-Sp 2024) - "The 1 group of 15 patients received pulsed dye laser (PDL) 595 nm procedures and topical therapy with 15% azelaic acid gel in combination with 1% ivermectin cream... All patients tolerated the treatment satisfactorily; no side effects were registered, which indicates the possibility of combined use of azelaic acid and ivermectin preparations in combination with botulinum therapy with incobotulinumtoxinA and PDL 595nm... According to the data of assessment of the dynamics of the DISS scale, the IGA index, DLQI the effectiveness of therapy of all treatment methods in relation to inflammatory, local and diffuse erythema is shown. Combination therapies are effective against both vascular and inflammatory components, local and diffuse erythema and increase patient satisfaction, represent a promising approach to the treatment of patients with erythematotelangiectatic and papulopustular subtypes of Rosacea."

Clinical • Dermatology • Dermatopathology • Rosacea

Combination treatment on clinical improvement in rosacea patients (EADV-Sp 2024) - "The 1 group of 15 patients received pulsed dye laser (PDL) 595 nm procedures and topical therapy with 15% azelaic acid gel in combination with 1% ivermectin cream... All patients tolerated the treatment satisfactorily; no side effects were registered, which indicates the possibility of combined use of azelaic acid and ivermectin preparations in combination with botulinum therapy with incobotulinumtoxinA and PDL 595nm... According to the data of assessment of the dynamics of the DISS scale, the IGA index, DLQI the effectiveness of therapy of all treatment methods in relation to inflammatory, local and diffuse erythema is shown. Combination therapies are effective against both vascular and inflammatory components, local and diffuse erythema and increase patient satisfaction, represent a promising approach to the treatment of patients with erythematotelangiectatic and papulopustular subtypes of Rosacea."

Clinical • Dermatology • Dermatopathology • Rosacea

Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris. (PubMed, Dermatol Ther (Heidelb)) - "The results indicate that 15% AzA gel effectively improved acne-induced PIE and PIH with minimal adverse reactions, making it a viable clinical application. In the study population, it had no adverse effects on skin barrier function and contributed positively to acne improvement and patient quality of life."

Clinical • Journal • Acne Vulgaris • Dermatology

15% azelaic acid gel efficacy on acne erythema and pigmentation (SID 2024) - No abstract available

Clinical • Acne Vulgaris • Dermatology

Microencapsulated Benzoyl Peroxide for Rosacea in Context: A Review of the Current Treatment Landscape. (PubMed, Drugs) - "It evaluates the efficacy, safety, and tolerability of various US Food and Drug Administration (FDA)-approved agents used for rosacea treatment, including E-BPO cream, metronidazole gel, azelaic acid gel and foam, ivermectin cream, minocycline foam, oral doxycycline, brimonidine gel, and oxymetazoline HCl cream...Further research is necessary to determine the exact role of E-BPO 5% in the therapeutic landscape for rosacea. However, based on available evidence, E-BPO 5% shows potential as a valuable treatment option for managing inflammatory lesions of rosacea, and it may offer benefits to patients including: rapid onset of action, demonstrated efficacy by Week 2, excellent tolerability, and sustained long-term results for up to 52 weeks of treatment."

Journal • Review • Dermatology • Rosacea

Comparison table: Some topical drugs for rosacea. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Dermatology • Rosacea

Drugs for rosacea. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Dermatology • Rosacea

Efficacy of combination therapy in patients with rosacea (EADV 2023) - "The first group of 12 patients received pulsed dye laser (PDL, with a wavelength of 595 nm) procedures and topical therapy with 15% azelaic acid gel in combination with 1% ivermectin cream...In the second group, 12 patients received intradermal injections of incobotulinumtoxinA in the area of redness with an interval of 1 cm between injections in combination with topical therapy with azelaic acid and ivermectin creams... Laser therapy PDL 595 nm is a leader in the treatment of individual telangiectasias and vascular pattern. Topical application of azelaic acid in combination with ivermectin shows a reduction in the inflammatory component in the form of pustules. Combination therapies are effective against both vascular and inflammatory components and represent a promising approach to the treatment of patients with erythematoteleangiectatic and papulopustular subtypes of Rosacea."

Clinical • Combination therapy • Dermatology • Dermatopathology • Inflammation • Rosacea

The efficacy of combination therapy in patients with rosacea (EADV 2023) - "The first group of 12 patients received pulsed dye laser (PDL, with a wavelength of 595 nm) procedures and topical therapy with 15% azelaic acid gel in combination with 1% ivermectin cream...In the second group, 12 patients received intradermal injections of incobotulinumtoxinA in the area of redness with an interval of 1 cm between injections in combination with topical therapy with azelaic acid and ivermectin creams... Laser therapy PDL 595 nm is a leader in the treatment of individual telangiectasias and vascular pattern. Topical application of azelaic acid in combination with ivermectin shows a reduction in the inflammatory component in the form of pustules. Combination therapies are effective against both vascular and inflammatory components and represent a promising approach to the treatment of patients with erythematoteleangiectatic and papulopustular subtypes of Rosacea."

Clinical • Combination therapy • Dermatology • Dermatopathology • Inflammation • Rosacea

Adult female acne: long-term follow-up after use of azelaic acid in the treatment, and during the maintenance phase (EADV 2023) - "Maintenance therapy brings significant improvement in the reduction of lesions in women with mild and moderate adult acne. As much as possible, systemic therapy is the choice, and anti-androgens, particularly spironolactone, which is considered the first option in association with topical agents, such as 15% azelaic acid gel, used twice a day. This is the best topical regimen."

Clinical • Acne Vulgaris • Dermatitis • Immunology • Seborrheic Dermatitis

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Mar 2024 ➔ Dec 2024 | Trial primary completion date: Nov 2023 ➔ Jun 2024

Trial completion date • Trial primary completion date • Alopecia

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2023 ➔ Mar 2024

Trial completion date • Alopecia

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Jul 2023 ➔ Dec 2023

Trial completion date • Alopecia

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences

New P1 trial • Alopecia

Pharmacological Interventions for Periorificial (Perioral) Dermatitis in Children and Adults: A Systematic Review. (PubMed, J Eur Acad Dermatol Venereol) - "Oral tetracycline may improve physician-reported severity of POD from day 20 onwards (low certainty evidence)...Pimecrolimus cream may improve physician-reported severity slightly after 4 weeks of treatment (MD -0.49, 95% CI -1.02 to 0.04, n=164, low certainty evidence)...Azelaic acid gel may result in no change in either physician- or patient-reported severity after 6 weeks of treatment. The evidence is very uncertain about the effect of praziquantel ointment on physician-reported severity and skin-related quality of life after 4 weeks of treatment. The evidence is also very uncertain about the effect of topical clindamycin/ benzoyl peroxide on physician-reported severity...Data is required for children and from low-middle income countries to improve external validity. Future trials should also include adequate post-treatment follow-up and standardized outcome measures."

Clinical • Journal • Review • Dermatitis • Dermatology • Herpes Simplex • Immunology • Infectious Disease • Pruritus • Rosacea

Minocycline foam (Zilxi) for rosacea. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Dermatology • Rosacea

Examining 15% Azelaic Acid Foam for the Treatment of Folliculitis: A Pilot Study. (PubMed, J Clin Aesthet Dermatol) - "The subjects reported a reduction of 60-percent in folliculitis itching, 67-percent reduction in pain, 73-percent reduction in lesional pus, 51-percent reduction in lesional redness, and 59-percent reduction in extent of folliculitis involvement. Azelaic acid 15% foam used off-label might be a useful treatment or adjunctive therapy for folliculitis."

Clinical • Journal • Dermatology • Immunology • Mood Disorders • Pain • Pruritus

Rosacea Treatment Satisfaction: Matching Adjusted Indirect Treatment Comparison Analysis of Metronidazole Gel or Cream vs Azelaic Acid Foam. (PubMed, J Drugs Dermatol) - "MG- and MC-treated patients more frequently reported treatment concerns and side effects than AAF-treated patients, and tolerability of those side effects was higher for patients treated with AAF. While treatment cost is a more frequent concern in patients treated with AAF, these patients less frequently reported concerns with treatment efficacy and reported similar or greater tolerance to side effects than patients treated with either MC or MG. J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.3679."

Journal • Dermatology • Dermatopathology • Rosacea