atiprimod (SK&F106615) / Synergy Pharma, Sanofi - LARVOL DELTA

Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells. (PubMed, Mol Biol Rep) - "Atiprimod induced prolonged ER stress-mediated apoptosis via both activating PERK/eIF2α/ATF4/CHOP axis and suppressing STAT3/NF-κB transcription factors nuclear migration in TBNC cells."

Journal • Breast Cancer • Gastrointestinal Cancer • Hematological Malignancies • Hepatocellular Cancer • Lymphoma • Multiple Myeloma • Oncology • Pituitary Gland Carcinoma • Solid Tumor • ATF4 • BECN1 • RELA • STAT1 • STAT3

Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways. (PubMed, J Cell Biochem) - "In addition, overexpression of STAT3 increased atiprimod-mediated cell viability loss and apoptotic cell death through suppressing autophagy and ER stress key molecules expression profile. In conclusion, a low dose of atiprimod exposure triggers autophagy and mild-ER stress as a survival mechanism, but increased atiprimod dose induced caspase-dependent apoptotic cell death by targeting STAT3 in GH3 pituitary adenoma cells."

Journal • Gastrointestinal Cancer • Hematological Malignancies • Hepatocellular Cancer • Hepatology • Multiple Myeloma • Oncology