allitinib (AST1306) / Allist - LARVOL DELTA

Massive Hepatic Necrosis in HELLP Syndrome (ATS 2025) - "Pertinent labs on presentation included: ALT 2,900 U/L AST 6,820 U/L, total bilirubin 1.9 mg/dL, INR 0.97, and Cr 2.79. Hepatic necrosis is a recognized catastrophic complication of HELLP syndrome, its occurrence postpartum is rare, and management requires a multidisciplinary approach and early referral to a liver transplant center. Few cases in the literature describe conservative management of hepatic necrosis, highlighting the need for further research to guide management without resorting to liver transplantation."

Atypical Hemolytic Uremic Syndrome • Complement-mediated Rare Disorders • Gynecology • Hematological Disorders • Hepatology • Immunology • Inflammatory Arthritis • Liver Failure • Lupus • Nephrology • Pain • Systemic Lupus Erythematosus

ERBB4 upregulation in a taxol-resistant triple-negative breast cancer cell line (AACR 2025) - "Treatment of the cells with ERBB inhibitors, sfatinib, allitinib, or PF299804, in sub-lethal concentration only induced a small additive effect on paclitaxel cytotoxicity in MDA-MB-231 cells, but dramatically enhanced paclitaxel cytotoxicity in T50RN cells. These results suggest that ERBB4 may play a critical role in paclitaxel resistance in T50RN cells. Further elucidation of how ERBB4 is induced in T50RN cells and how ERBB4 regulates cell resistance might provide leads to overcome paclitaxel resistance."

Preclinical • Breast Cancer • HER2 Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • ERBB3 • ERBB4 • HER-2

Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid. (PubMed, J Pers Med) - "OCA treatment led to a statistically significant decrease in aspartate aminotransferase (AST; AST baseline: 38.50 [26.25; 50.00] IU/L vs. AST 6-month follow-up: 23.50 [21.50; 44.25] IU/L, p = 0.0012), alanine aminotransferase (ALT; ALT baseline: 55.50 [28.75; 97.00] IU/L vs. ALT 6-month follow-up: 36.50 [28.00; 57.25] IU/L, p = 0.0035), and gamma-glutamyl transferase (GGT; GGT baseline: 168.00 [100.30; 328.50] IU/L vs. GGT 6-month follow-up: 88.00 [44.50; 259.80] IU/L, p = 0.0063), while the decrease in alkaline phosphatase (AP) was not statistically significant (AP baseline: 197.00 [170.00; 253.30] IU/L vs. AP 6-month follow-up: 196.00 [134.00; 227.00] IU/L, p = 0.0915). In none of our patients did therapy with obeticholic acid have to be stopped due to pruritus or poor tolerability. In patients with PBC without adequate response to UDCA, OCA is a promising alternative, which in our group of 16 patients led to a significant improvement of liver enzymes, the..."

Journal • Autoimmune Hepatitis • Cholestasis • Dermatology • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Primary Biliary Cholangitis • Pruritus • Transplantation

To Evaluate the Efficacy and Safety of Anlotinib Combined with Aumolertinib in Lung Cancer (clinicaltrials.gov) - P2 | N=36 | Completed | Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Not yet recruiting ➔ Completed

Trial completion • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

A case of MPGN with TMA in HCV-negative adolescent (IPNA 2025) - "AST 6.6U/L, ALT 8.8 U/L, Urea 29.5 mmol/L, Crea 602 umol/L, LDG 1112, aPTT- 44.6; D-Dimer - 1.53 mg/l, рН- 7.34; рСО2- 44.1; рО2- 61.6; НСО3- 23.4...Two doses of Rituximab (500mg) were administered, and the patient was discharged home...Conclusions In this report, we describe a child with progressive renal failure and pathology exhibiting a membranoproliferative pattern. We thus conclude that this patient exhibited an unusual presentation of chronic thrombotic microangiopathy mimicking MPGN Type II."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Complement-mediated Rare Disorders • Epilepsy • Glomerulonephritis • Hepatitis C • Hepatology • Hypertension • Infectious Disease • Inflammation • Lupus Nephritis • Nephrology • Renal Disease • Thrombosis

Unveiling the role of MGMT and DAPK hypermethylation in response to anti-EGFR agents: Molecular insights for advancing HNSCC treatment. (PubMed, Head Neck) - "These findings hold promise for the development of more personalized and effective treatment approaches for HNSCC patients."

Journal • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CCNA1 • CDKN2A • MGMT

CARDIOGENIC SHOCK AFTER VENLAFAXINE OVERDOSE (CHEST 2023) - "CASE PRESENTATION: A 21-year-old female with history of depression and no known cardiac disease was brought to the ED after ingestion of 14,100 mg of venlafaxine extended-release in a suicide attempt...Lab work showed elevated transaminases (ALT 3,914, AST 6,132), and elevated troponin (72 ng/L)...Three hours later, she had a tonic-clonic seizure, so lorazepam was administered and she was emergently intubated for airway protection...Dobutamine infusion was started and echocardiogram confirmed left ventricular dysfunction with ejection fraction (EF) of 35-40%... As venlafaxine is commonly prescribed for depression, patients and physicians should be aware of potential serious cardiac complications at higher doses."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Epilepsy • Heart Failure • Psychiatry

Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines. (PubMed, Int J Mol Sci) - "Our results indicate that allitinib was more effective than afatinib in NSCLC cell lines. KRAS mutations increased aggressive behavior through upregulation of the focal adhesion-PI3K-Akt-mTOR-signaling in NSCLC cells. Significantly, everolimus restored sensibility and improved cytotoxicity of EGFR inhibitors in the KRAS mutant NSCLC cell lines."

Journal • Preclinical • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • KRAS

The implication of RKIP loss in primary resistance to EGFR inhibitors in NSCLC: a novel predictive biomarker? (EACR 2022) - "The role of RKIP in the response to EGFR inhibitors was evaluated in vitro through cytotoxicity assays (MTS) and real-time cell analysis (xCELLigence), using Erlotinib, Afatinib, Allitinib and Osimertinib drugs. When assessing the activation levels of EGFR related signaling pathways upon treatment, AKT pathway was overactivated in RKIP KO cells, thus shedding light on the possible mechanism of resistance behind RKIP’s loss. Conclusion To sum up, these results show the potential of RKIP as a negative predictive biomarker to EGFR targeted therapy response in NSCLC."

Biomarker • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • PEBP1

A real world study on the relationship between drug resistance of targeted therapy and prognosis of HER-2-positive advanced breast cancer (PubMed, Zhonghua Zhong Liu Za Zhi) - "Among them, targeted drugs for HER-2 included trastuzumab, pertuzumab, T-DM1, RC48-ADC, lapatinib, pyrotinib, allitinib, sipatinib, seratinib. The median overall survival time of the two groups was 24.9 months and 40.4 months, respectively, with statistical significance (P<0.001). Primary resistance to HER-2 is one of the factors of poor prognosis in HER-2 positive breast cancer, and its mechanism needs to be further explored."

Journal • Real-world evidence • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Oncology • Solid Tumor • HER-2

[VIRTUAL] DIFFERENTIATING ACETAMINOPHEN (APAP) OVERDOSE FROM ISCHEMIC HEPATITIS (IH) IN PATIENTS WITH ACUTE LIVER FAILURE (ALF): ROLE OF SERUM APAP ADDUCTS (AASLD 2021) - "Median peak lab values for APAP and IH cases respectively were similar: APAP: AST 6,491 IU/L, ALT 4,553 IU/L, Bili 4.5 mg/dL; Ischemia: AST 4930 IU/L, ALT 3226 IU/L, Bili 3.15 mg/ dL . The interchangeable clinical scenarios (found unresponsive with high ALT) make it difficult to reliably distinguish APAP from IH . Presence/absence of serum APAP adducts resolves many (xx) of these cases. We identified 6% with combination injuries (APAP or ischemia plus DILI, etc.) and an additional 1% with apparent combination APAP/ Ischemia injury."

Clinical • Hematological Disorders • Hepatology • Hypotension • Inflammation • Liver Failure • Respiratory Diseases

[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. (EACR 2021) - "The genetic manipulated cell lines were used to assessed IC50 values for EGFR inhibitors (AST1306, lapatinib and afatinib). These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients."

Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. (EACR 2021) - "The genetic manipulated cell lines were used to assessed IC50 values for EGFR inhibitors (AST1306, lapatinib and afatinib). These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients."

Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. (EACR 2021) - "The genetic manipulated cell lines were used to assessed IC50 values for EGFR inhibitors (AST1306, lapatinib and afatinib). These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients."

Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. (EACR 2021) - "The genetic manipulated cell lines were used to assessed IC50 values for EGFR inhibitors (AST1306, lapatinib and afatinib). These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients."

Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Induction of Phlorotannins and Gene Expression in the Brown Macroalga Fucus vesiculosus in Response to the Herbivore Littorina littorea. (PubMed, Mar Drugs) - "Soluble phlorotannin levels remained stable during the kinetics and increased significantly only after 12 h in the presence of grazers, compared to the control, before decreasing to the initial steady state for the rest of the kinetics. Under grazing conditions, the expression of vbpo, cyp450 and ast6 genes was upregulated, respectively, at 6 h, 12 h and 24 h, and cyp450 gene was downregulated after 72 h. Interestingly, the pksIII gene involved in the synthesis of phloroglucinol was overexpressed under grazing conditions after 24 h and 72 h. This study supports the hypothesis that phlorotannins are able to provide an inducible chemical defense under grazing activity, which is regulated at different stages of the stress response."

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To Evaluate the Efficacy and Safety of Anlotinib Combined With Allitinib in Lung Cancer (clinicaltrials.gov) - P2; N=36; Not yet recruiting; Sponsor: Chinese Academy of Medical Sciences

Clinical • New P2 trial • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Electromuscular Incapacitation Current Induced Neuromuscular Tissue Injury. (PubMed, Bioelectromagnetics) - "Maximal energy cardiac defibrillator pulses resulted in rhabdomyolysis and marked elevation of CPK, LDH, and AST 6 h post-shock. Bioelectromagnetics."

Journal • Anesthesia • Atrial Fibrillation • Cardiovascular • Metabolic Disorders • Mood Disorders

A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors (J Hematol Oncol) - P1, N=71; “During dose escalation, the key DLT was grade 3 diarrhea observed in 5 patients at 1000 mg BID (n = 1), 1500 mg BID (n = 1), 800 mg TID (n = 1) and 1200 mg TID (n = 2). AST1306 was rapidly absorbed and had moderate to high clearance….Of the 55 evaluable patients, 7 patients experienced partial responses, including 5 with breast cancer, 1 with lung cancer, and 1 with gastric cancer. The best response with stable disease for >= 6 months was achieved in 7 patients.” 

P1 data • Oncology

A hidden human proteome encoded by 'non-coding' genes. (PubMed, Nucleic Acids Res) - "As the new protein UBAP1-AST6 is localized in the nucleoli and is preferentially expressed by lung cancer cell lines, we biologically verified that it has a function associated with cell proliferation. In sum, we experimentally evidenced a hidden human functional proteome encoded by purported lncRNAs, suggesting a resource for annotating new human proteins."

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