AMP-110 / AstraZeneca, Daiichi Sankyo - LARVOL DELTA

Comparison of constant load exercise intensity for verification of maximal oxygen uptake following a graded exercise test in older adults. (PubMed, Physiol Rep) - "No significant differences were observed for peak VO (L·min ) between CL85 (1.86 ± 0.72; p = 0.679) or CL110 (1.79 ± 0.73; p = 0.200) and the associated ramp (Ramp85, 1.85 ± 0.73; Ramp110, 1.85 ± 0.57). Using the study participant's mean coefficient of variation in peak VO between the two identical ramp tests (2.9%) to compare individual differences between constant load tests and the associated ramp revealed 19/22 (86%) of participants achieved a peak VO during CL85 that was similar or higher versus the ramp, while only 13/20 (65%) of participants achieved a peak VO during CL110 that was similar or higher versus the ramp. These data indicate that if a verification of VO max is warranted when testing older adults, a constant load effort at 85% of ramp peak power may be more likely to verify VO max as compared to an effort at 110% of ramp peak power."

Clinical • Journal