aptamer-based therapeutics / Archemix, GSK - LARVOL DELTA

Strategies for the Evaluation and Characterization of Higher-Order Structures, Supramolecular Higher-Order Structures, and Aggregates in Oligonucleotide Therapeutics. (PubMed, J Pharm Sci) - "Synthetic oligonucleotides have emerged as a promising therapeutic class, holding significant potential for the treatment of a wide range of indications, including previously undruggable targets...Based on industry experience and available literature, we also propose strategies for their evaluation and characterization under relevant conditions. The recommended approach involves conducting appropriate scientific assessments during product development with the support of designed workflows, which can help anticipate and/or mitigate the formation of unintended species."

Journal • Review