ATG-106 / Antengene - LARVOL DELTA

ATG-106, a novel '2+1' format CDH6-targeted T-cell engager (TCE), shows potent T cell dependent cytotoxicity and in vivo anti-tumor efficacy (SITC 2024) - "0.1 mg/kg, 0.3 mg/kg, and 1 mg/kg ATG-106 produced significant anti-tumor efficacy with mean TGI values of 132.53%, 140.34%, and 140.23%, respectively. Complete tumor remission was observed in 0.3 mg/kg (3 out of 6 mice) and 1 mg/kg (3 out of 6 mice) treatment groups"

Preclinical • Endocrine Cancer • Genito-urinary Cancer • Hematological Malignancies • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • Thyroid Gland Carcinoma • CDH2 • CDH6

Title: ATG-106, a novel "2+1" format CDH6-targeted T-cell Engager (TCE), shows potent T cell dependent cytotoxicity and in vivo anti-tumor efficacy (PRNewswire) - "Antengene Corporation Limited...announced that it will present results from...programs at the 2024 Society for Immunotherapy of Cancer Annual Meeting (SITC 2024)....Abstract Number: 1069:....ATG-106, a '2+1' CDH6 x CD3 TCE, was designed to address CRS challenge by targeting CDH6 and activating T cells only in the presence of CDH6-positive cells, minimizing CRS risk. Preclinical studies showed strong binding affinity to CDH6+ cells and potent T-cell-dependent cytotoxicity. It induced lower cytokine release in vitro compared to benchmarks. In vivo studies using ovarian cancer xenograft models demonstrated that ATG-106 achieved significant tumor growth inhibition (TGI) with tumor shrinkage and complete remission observed in multiple treatment groups."

Preclinical • Ovarian Cancer

Antengene to Present Results from Three Programs at the 2024 SITC Annual Meeting (PRNewswire) - "Antengene Corporation Limited...announced that it will present three programs at the 2024 Society of Immunology in Cancer Annual Meeting (SITC 2024) to be held in Houston from November 6-10, 2024."

Preclinical • Acute Myelogenous Leukemia