amoxicillin / Generic mfg. - LARVOL DELTA

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study) (clinicaltrials.gov) - P1 | N=108 | Completed | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Active, not recruiting ➔ Completed | Trial completion date: Dec 2025 ➔ May 2025 | Trial primary completion date: Dec 2025 ➔ May 2025

Trial completion • Trial completion date • Trial primary completion date

Assessment of seasonality in antimicrobial susceptibility testing and resistance of urinary Escherichia coli from dogs and cats in the United States (2019 - 2022). (PubMed, Prev Vet Med) - "Urinary E. coli isolates from dogs and cats had the highest resistance to amoxicillin at 27.9 % (95 % CI: 27.7-28.1) and 28.4 % (95 % CI: 28.1-28.7), respectively, among all antimicrobials tested...The hot-humid zone had the highest resistance rates but the lowest AST rates per one million dogs and cats. Seasonality in AST suggests a seasonal pattern for UTIs; however, no seasonal pattern in AMR could be observed nationally or regionally for urinary E. coli isolates."

Journal • Infectious Disease • Nephrology

A Learning Collaborative to Improve Antibiotic Use for Otitis Media and Pharyngitis in Pediatric Urgent Care Clinics. (PubMed, Pediatr Emerg Care) - "This multicenter collaborative provided education and networking to increase the use of delayed antibiotics for AOM in pediatric UCCs."

Journal • Critical care • Otorhinolaryngology • Pediatrics

Sulbactam-durlobactam improves cephalosporin and carbapenem susceptibility and time-kill effect against Mycobacterium abscessus. (PubMed, Microbiol Spectr) - "The fold reduction in MICs was as follows: amoxicillin 94, ceftriaxone 103, cefuroxime 69, cefdinir 19, cefalexin 74, imipenem 23, meropenem 37, tebipenem 89, and faropenem 74. We show that sulbactam/durlobactam (Sul/Dur) can improve the kill effect of several β-lactam antibiotics that, otherwise, due to observed high minimum inhibitory concentration, deem ineffective. Based on our findings, we propose imipenem that is already included in the MAB-LD treatment recommendations and ceftriaxone that achieves very high lung concentration, to test with Sul/Dur as a double β-lactam-β-lactamase backbone regimen to advance the therapy for MAB-LD."

Journal • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases

Australian Gonococcal Surveillance Program, 1 January to 31 March 2025. (PubMed, Commun Dis Intell (2018)) - "The antibiotics reported represent current or potential agents used for the treatment of gonorrhoea, and include ceftriaxone, azithromycin, ciprofloxacin and penicillin. More recently, gentamicin and tetracycline are included in the AGSP Annual Report...In these regions, an oral treatment regimen comprising amoxycillin, probenecid, and azithromycin was recommended. However, since January 2023, increasing reports of penicillin-resistant N. gonorrhoeae in the Northern Territory have changed treatment recommendations to align with the majority of Australia.1 Additional data on other antibiotics are reported in the AGSP Annual Report. The AGSP has a programme-specific quality assurance process."

Journal • Infectious Disease

Huazhi Rougan Granule as an Add-On Therapy for H. Pylori Infection With Metabolic-associated Steatohepatitis (clinicaltrials.gov) - P=N/A | N=286 | Not yet recruiting | Sponsor: Nanjing First Hospital, Nanjing Medical University

New trial • Hepatology • Infectious Disease

Efficacy and safety of dostarlimab in elderly patients with multiple comorbidities and allergic diathesis: case report. (PubMed, AME Case Rep) - "Medical history was positive for arterial hypertension, autoimmune thrombocytopenia and allergy to amoxicillin and levofloxacin. The administration of dostarlimab is safe and feasible in elderly people with multiple pathologies and multiple allergies with recurrent dMMR/MSI EC. The drug is well tolerated and able to give a good quality of life to patients."

dMMR • Journal • MSI-H • Allergy • Cardiovascular • Endometrial Cancer • Hematological Disorders • Hypertension • Immune Thrombocytopenic Purpura • Immunology • Microsatellite Instability • Oncology • Pulmonary Arterial Hypertension • Solid Tumor • Thrombocytopenia • Thrombocytopenic Purpura • MSI

Expansion of the pharmaceutical assays available to DPAL (ACS-Fall 2025) - "Herein, we discuss the efforts of our undergraduate research program to expand DPAL analytical assays to include the use of LC-MS and gas chromatography (GC). Simple, user-friendly methods have been developed for the accurate and precise analyses of amoxicillin and hydroxyurea to within 1% error."

Pharmaceutical quantification by UPLC-MS (ACS-Fall 2025) - "Amoxicillin, a widely used antibiotic, and leucovorin, an antidote to the harmful effects of chemotherapy, are frequently found to be substandard, leading to harmful consequences such as increased antimicrobial resistance and poor patient health outcomes. By optimizing injection volumes, generating reliable calibration curves, and evaluating matrix effects, our methods enable reproducible active pharmaceutical ingredient (API) detection at nanomolar concentrations. By leveraging UPLC-MS, DPAL enhances its capacity to detect a broader range of pharmaceutical quality issues, ultimately supporting global efforts to improve medicinal safety and public health."

Ten years of the distributed pharmaceutical analysis laboratory (DPAL) (ACS-Fall 2025) - "DPAL partners in LMICs provide samples of pharmaceutical products such as amoxicillin capsules, ciprofloxacin tablets, and dosage units of MESNA or leucovorin calcium, and analytical chemistry students perform system suitability testing, evaluate the quality of the pharmaceutical dosage forms, and may apply other analytical techniques to learn more about products that fail assay. Sample metadata, provenance, and test results are shared between the LMIC collection sites and the DPAL laboratories through a secure database called VERIFY. This presentation will highlight how the program has evolved over a decade."

Shifts in Epidemiology and Antibiotic Resistance of Haemophilus Influenzae in Children From Chongqing (2019-2024): Pre-, During, and Post-COVID-19. (PubMed, Infect Drug Resist) - "High resistance was found for ampicillin (79.05%), cefuroxime (58.95%), ampicillin-sulbactam (59.82%), sulfamethoxazole-trimethoprim (68.51%), azithromycin (49.67%), and cefixime (37.78%), while meropenem (0.48%), levofloxacin (0.11%), chloramphenicol (4.85%), ceftriaxone (0.62%), rifampicin (0.15%), tetracycline (5.55%), and cefepime (6.11%) showed low resistance. The COVID-19 pandemic affected resistance patterns: resistance to ampicillin, aztreonam, cefuroxime, amoxycillin-clavulanic, and ampicillin-sulbactam were higher before and after the COVID-19 pandemic than during it (p< 0.001)...The COVID-19 pandemic influenced infection patterns of specific age groups and resistance trends. Caution is required for commonly resistant antibiotics, and continuous resistance monitoring is necessary."

Journal • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases

Hospital Admissions and Antimicrobial Resistance Patterns in Diabetic Patients With Urinary Tract Infections: A Cross-Sectional Study From a Tertiary Care Center in Pakistan. (PubMed, Cureus) - "High resistance rates were seen for amoxicillin in 154 (75.1%) and cotrimoxazole in 139 (67.8%) isolates, while nitrofurantoin and ceftriaxone demonstrated high sensitivity in 174 (84.9%) and 166 (81.0%) cases, respectively. Conclusion It is concluded that urinary tract infections are a common and serious cause of hospital admissions in diabetic patients, particularly those with advanced age, poor glycemic control, and long-standing diabetes. Escherichia coli remains the predominant pathogen with evolving antimicrobial resistance trends."

Journal • Observational data • Cardiovascular • Diabetes • Diabetic Nephropathy • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Renal Disease

Aerococcus urinae Spondylodiscitis: A Case Report and Review of the Literature. (PubMed, Case Rep Infect Dis) - "Amoxicillin was administered intravenously for 14 days, followed by oral levofloxacin for 3 months. A. urinae should be considered in spondylodiscitis with negative cultures, particularly in older men with diabetes and urological conditions."

Journal • Back Pain • Cardiovascular • Diabetes • Infectious Disease • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Nephrology • Orthopedics • Pain

Identification, and characterization of Escherichia coli O157:H7 from animal-derived foods in Hawassa and Yirgalem, Sidama Region, Ethiopia. (PubMed, J Food Prot) - "All E. coli O157:H7 isolates were susceptible to most tested antibiotics; however, resistance was observed against amoxicillin (81.8%), streptomycin (45.5%), and clindamycin (100%). Additionally, 45.5% of isolates exhibited multidrug resistance with an multidrug resistance (MDR) index of 0.27, though none produced extended-spectrum beta-lactamases (ESBL). These findings underscore the necessity for stringent hygiene practices and effective monitoring of animal-derived foods to mitigate public health risks."

Journal

Association between systemic exposure to antibiotics in early childhood and molar-incisor hypomineralization (MIH): A systematic review and meta-analysis. (PubMed, J Dent) - "MIH poses diagnostic and treatment challenges. Contributing factors must be identified judiciously. Prudent antibiotic use should be integrated into clinical practice to reduce potential risk and promote better long-term oral health in children."

Journal • Retrospective data • Review

Acute generalized exanthematous pustulosis: 15-year retrospective multicenter experience. (PubMed, Clin Exp Dermatol) - "Despite its retrospective design, this study contributes valuable insights into the systemic implications and histopathological characteristics of AGEP, highlighting the possible role of LDH, and the importance of further research to refine diagnosis, treatment protocols and improve patient outcomes."

Clinical • Journal • Retrospective data • Immunology • Inflammation

Ten-Day Versus 14-Day Vonoprazan and Amoxicillin Dual Therapy for the Firstline Eradication of Helicobacter pylori Infection: A Multicenter, Randomized Controlled Trial. (PubMed, Helicobacter) - P4 | "The noninferiority of eradication efficacy between 10- and 14-day VA-DT in the first-line treatment was not established, indicating that 10-day therapy cannot be used as a substitute for 14-day therapy. Vonoprazan exerted excellent gastric acid suppression during eradication."

Clinical • Journal • Infectious Disease

Different Amoxicillin Treatment Regimens in Erythema Migrans Patients (clinicaltrials.gov) - P=N/A | N=510 | Recruiting | Sponsor: University Medical Centre Ljubljana | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial completion date • Trial primary completion date • Dermatology • Lyme Disease

Identifying Successful Pediatric Outpatient Antimicrobial Stewardship Strategies through Benchmarking: A Multi-Institutional Project. (PubMed, Am J Infect Control) - "Although we did not observe a decrease in antibiotic use for ARI after providing benchmarking reports, there was improvement in antibiotic selection. Guidelines and QI initiatives may have the biggest impact on improving antibiotic use metrics."

Journal • Infectious Disease • Pediatrics • Respiratory Diseases

Comparison of vonoprazan with different frequency Amoxicillin regimens in the treatment of Helicobacter pylori infections: A retrospective study. (PubMed, Medicine (Baltimore)) - "Amoxicillin administered 4 times daily is more effective than 3 times daily in eradicating Hp, with an eradication rate > 90% and lower adverse events incidence, improving related discomfort symptoms. This regimen is recommended as the first-line treatment for Hp."

Clinical • Journal • Observational data • Retrospective data • Infectious Disease

Novel chromogenic medium-based method for the rapid detection of Helicobacter pylori drug resistance. (PubMed, World J Gastroenterol) - "The novel detection method can rapidly detect H. pylori drug resistance within 28-36 hours. With its operational simplicity and high diagnostic performance, it holds strong potential for clinical application in the management of H. pylori antimicrobial resistance."

Journal • Infectious Disease

A Single Amino Acid in PBP1a Drives High-Level Penicillin and Amoxicillin Resistance in Streptococcus suis. (PubMed, Int J Antimicrob Agents) - "Furthermore, 95.56% (366/383) of penicillin-susceptible strains carried S at position 695 of PBP1a. This study provides new insights into the molecular mechanisms driving penicillin and amoxicillin resistance in S. suis."

Journal

Bacterial load assessment and multi-drug resistant Bacteria isolation from Fuchka in Mymensingh City, Bangladesh. (PubMed, One Health) - "Resistance to amoxicillin was observed in 100 % of Gram-negative isolates...The MAR index ranged from 0.1 to 0.6. These findings highlight urgent public health concerns and emphasize the need for integrated food safety strategies under the One Health approach."

Journal • Infectious Disease • Pneumonia

Molecular Characterization of β-Lactamase-Resistant Klebsiella aerogenes Isolated from Raw Milk in Bangladesh. (PubMed, Foodborne Pathog Dis) - "Due to the overwhelming challenges of antimicrobial resistance, the transmission of antibiotic resistance genes, and mobile colistin resistance (mcr) genes through zoonotic organisms, this study aimed to characterize K. aerogenes in raw milk in Sylhet...Among 234 samples, 86 (36.44%) were positive for Klebsiella and exhibited variation in resistance levels to amoxicillin (100%), ampicillin (100%), ceftazidime (100%), tetracycline (100%) followed by azithromycin (89.54%), cefoxitin (86.04%), gentamicin (83.74%), and cefuroxime (77.90%)...These findings underscore that raw milk could be a potential harbor for multidrug resistance K. aerogenes, raising concerns about antimicrobial resistance transmission through traditionally processed dairy products, as such products are often prepared without proper heat treatment. The study emphasizes the need for strict hygiene practices and mandatory pasteurization measures during processing to reduce potential public health risks."

Journal

Detection and antimicrobial susceptibility of E. coli O157:H7 in the milk supply chain, milking environments and humans in Woliata Sodo, Ethiopia. (PubMed, BMC Microbiol) - "This study confirmed the presence of multidrug resistant E. coli O157:H7 in the tested sample. Notably, the highest prevalence was detected in milk samples from collection centers, underscoring post harvest contamination as a critical point of intervention. Identification of the pathogen on milkers' hands, farm floors, and human stool samples highlights potential transmission pathways and suggests a tangible risk of foodborne infections. These findings emphasize the critical need for targeted public health strategies, including comprehensive education on hygienic practices and the implementation of effective contamination control measures, to reduce the risk of infection and protect consumer health."

Journal • Infectious Disease