ALG-005398 / Aligos Therap - LARVOL DELTA

Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles. (PubMed, J Virol) - "Here, we report on the first non-HAP CAM-As ALG-005398 and ALG-005863 and provide a detailed in vitro intracellular characterization...These so-called non-HAP CAM-As have intriguing properties in cell culture but also clear virus-infected cells from the mouse liver in a gradual and sustained way. We believe they represent a considerable improvement over previously reported molecules and may one day be part of curative treatment combinations for chronic hepatitis B."

Journal • Preclinical • Gastrointestinal Cancer • Hematological Malignancies • Hepatitis B • Hepatology • Infectious Disease • Inflammation • Leukemia • Liver Cancer • Oncology • Solid Tumor

NON-HAP CLASS I CAPSID ASSEMBLY MODULATORS HAVE DISTINCT PROFILES AND A DIFFERENTIATED MECHANISM OF ACTION (AASLD 2022) - "Non-HAP CAM1s such as ALG-005398 and ALG-006162 have a profile that is clearly distinct from known HAP CAM1s such as RG7907. Their underlying mechanisms of action governing in vivo HBsAg reduction are also clearly differentiated. Since optimized non-HAP CAM1s have suitable ADME / tox profiles, they represent an attractive class of molecules for further development as a part of potential functional cure regimens for CHB, offering a potential advantage over HAPs."

Hepatitis B • Hepatology • Infectious Disease • Inflammation • CALM2