atosiban / Generic mfg. - LARVOL DELTA

The effectiveness and safety of continuous and repeated treatment of atosiban in twin pregnancy with threatened preterm labor: A propensity score-matched study. (PubMed, PLoS One) - "This propensity score-matched study suggests that continuous and repeated treatment with atosiban may effectively prolong pregnancy in cases of twin pregnancies with threatened preterm labor. Continuous and repeated treatment with atosiban was associated with lower fetal distress and lower NICU admission but no effect in adverse neonatal outcomes as well as the incidence of chorioamnionitis."

Journal • Retrospective data • Critical care • Gynecology • Obstetrics

The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study. (PubMed, Front Endocrinol (Lausanne)) - "These results suggested that adding atosiban in the standard FET cycles might not improve the live birth rate. To confirm this conclusion, more thorough, prospective randomized controlled studies of sizable sample sizes with good design are required."

Journal • Retrospective data

Phylloplane Bacterial Exometabolites Suppress Xanthomonas axonopodis pv. punicae: Metabolomic and Genomic Insights for Bacterial Blight Management in Pomegranate. (PubMed, Microb Pathog) - "LC-MS/MS profiling revealed the presence of bioactive metabolites such as Bacillomycin D, Fengycin, and Iturin A in Bacillus spp.; Macrolactin (6.3 μg/mL), Macrolactin W (4.1 μg/mL), and sucrose palmitate (2.8 μg/mL) in Erwinia; and Cyclo(l-Pro-l-Tyr), Tryptophol, Dapdiamide A and B, and Pantocin A and B in Pantoea...Phylogenetic analysis based on 100 conserved protein-coding genes placed P. dispersa Pg-Slp6 in a distinct clade, underscoring its unique genomic identity. These findings establish P. dispersa Pg-Slp6 as a robust candidate for developing phylloplane-adapted microbial formulations aimed at the eco-friendly and effective management of bacterial blight in pomegranate."

Journal

The interplay between oxytocin receptor and YAP in regulating gastric cancer progression. (PubMed, Oncogene) - "The use of the OXTR antagonist Atosiban to inhibit OXTR activity promotes the phosphorylation of LATS1 by ARRB2, which subsequently suppresses YAP phosphorylation. This results in the sequestration of YAP in the cytoplasm, thereby inhibiting the progression of gastric cancer."

Journal • Gastric Cancer • Oncology • Solid Tumor • LATS1

Exometabolome of Pantoea targets pathogen associated scytalone dehydratase and XopQ for suppression of foliar blast and bacterial blight in rice. (PubMed, Int J Biol Macromol) - "UPLC-QToF-ESI profiling identified metabolites such as dapdiamide and pantocins, which exhibited strong antimicrobial properties...The combined effects of direct antimicrobial action, suppression of pathogen virulence, and activation of host defenses highlight the potential of Pantoea exometabolomes as a biocontrol strategy. This study underscores their role in sustainable disease management and presents a viable alternative to chemical-based crop protection methods."

Journal

Analysis of the effect of oxytocin analogues on a mouse contextual fear-conditioning behavior (CINP-AsCNP 2025) - "Aims & Objectives: In the present study, we examined whether oxytocin and its analog (carbetocin and atosiban) could reduce fear-conditioning behavior of mice that is often applied in the studies of dental phobia. The results of this study suggest that intranasal administration of carbetocin immediately after electric shock session effectively reduces fear memory formation in mice. Carbetocin selectively activates the Gq protein-related response of the oxytocin receptor, suggesting that selective responses downstream of the oxytocin receptor may contribute to the reduction of the fear conditioning effect. However, further analysis is needed to clarify which neural nuclei and neural circuits carbetocin targets."

Preclinical • FOS

Brain tumour during pregnancy: Clinical and surgical management of a challenging case (Euroanaesthesia 2025) - "Periodic fetal monitoring and tocolytic infusion with atosiban were maintained throughout.Drainage through the Ommaya chamber provided symptom relieve, and a c-section was planned at 37th week of gestation.Cesarian was performed under total intravenous anesthesia (TIVA) using propofol target-controlled infusion, RSI and videolaryngoscopy to secure the airway...C-section was uneventful, and a healthy male newborn was delivered.Two months later, the mother was submitted to suboccipital craniotomy with excision of the posterior fossa lesion, a pilocytic astrocytoma, and removal of the Ommaya reservoir, under TIVA, with no complications. An experienced team involving Neurosurgery, Obstetrics, Neonatology and Anesthesiology was crucial to ensure mother, fetus and neonate health. Optimal timing, coordination and accurate anesthetic management of the surgical procedures minimized the risk of complications and allowed a positive outcome."

Clinical • Anesthesia • Astrocytoma • Brain Cancer • Obstetrics • Oncology • Pilocytic Astrocytoma • Rare Diseases • Solid Tumor

Apelin-13 elicits lordosis behavior in female rats through the oxytocin/prostaglandin E2/GnRH signaling system. (PubMed, Horm Behav) - "The inhibitors used included atosiban (ATO), an OT receptor antagonist; acetylsalicylic acid (aspirin), a cyclooxygenase-2 (COX-2) inhibitor; ONOAE3-208 (ONO), a PGE2 receptor antagonist; RU486, an antiprogestin for the PR; and antide, a GnRH-1 receptor antagonist. In contrast, aspirin only decreased the LQ at 30 and 120 min, while the LS was reduced at all times tested. Because the OT/PGE2/GnRH pathway has been widely demonstrated in hypothalamic astrocytes as a regulator of GnRH release, it may also play a role in regulating female sexual behavior in estradiol-pretreated rats."

Journal • Preclinical

Pituitary Suppression in Conjunction with Atosiban Administration Could Improve Pregnancy Outcome of Frozen-thawed Embryo Transfer in Women with Endometriosis (WCE 2025) - "However, findings are limited by small sample sizes and lack of detailed severity assessment. Larger randomized trials stratifying by endometriosis phenotype and severity are needed to confirm effectiveness and optimize FET strategies."

Clinical • Endometriosis • Gynecology • Women's Health

Proton pump inhibition to prevent delayed chemotherapy-induced nausea and vomiting in patients receiving adjuvant or neoadjuvant breast cancer chemotherapy: a phase II, randomised double-blind crossover trial (PantoCIN). (PubMed, Support Care Cancer) - P2 | "Pantoprazole is a cost-effective and safe agent, which reduces rates of delayed nausea and should be considered as prophylaxis in patients undergoing emetogenic chemotherapy."

CINV • Journal • P2 data • Breast Cancer • Chemotherapy-Induced Nausea and Vomiting • Dyspepsia • Oncology • Solid Tumor

The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats. (PubMed, Neuropharmacology) - "Late hypersensitivity correlated with increased levels of phosphorylated S6 protein in the spinal tissue, an effect partly blocked by atosiban. These data suggest that carbetocin prevents early nociception in males via OTR-Gq, and atosiban blocks late hypersensitivity in both sexes via OTR-Gi/o, implying that OTR-biased activation underlies the sexual dimorphism observed in oxytocin-induced antinociception."

Journal • Preclinical • Immunology • Infectious Disease • Inflammation • Pain • Respiratory Diseases

Inhibition of TRPM3 by Primidone Provides a Potential Therapeutic Method for Adenomyosis Management. (PubMed, Drug Des Devel Ther) - "To test the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of primidone on tamoxifen-induced adenomyosis mice...From 10 weeks after birth, primidone (2 mg/kg/d) and atosiban (1 mg/kg/d) were given separately to adenomyotic mice by intraperitoneal injection for 3 weeks...Forty-seven DEGSSs were identifieSd after primidone treatment, and bioinformatics analysis predicted that they were enriched in the cell cycle and cell division. The expression profile of TRP channels varies significantly in adenomyosis patients, and primidone may provide a potential therapeutic method for adenomyosis management."

Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health • TRPA1 • TRPM3 • TRPV1

Atosiban and managing women in preterm labour. (PubMed, Lancet) - No abstract available

Journal

Atosiban versus placebo for threatened preterm birth (APOSTEL 8): a multicentre, randomised controlled trial. (PubMed, Lancet) - P4 | "We did not demonstrate superiority of atosiban over placebo in improving neonatal outcomes as treatment for threatened preterm birth from 30+0 to 33+6 weeks of gestation. As the primary goal of tocolysis should be improvement of neonatal outcomes, our outcomes question the standardised use of atosiban as treatment for threatened preterm birth from 30+0 to 33+6 weeks of gestation. Our findings should reduce practice variation across countries and will contribute to evidence-based treatment for patients with threatened preterm birth."

Journal

Atosiban in individuals with previous implantation failure undergoing frozen blastocyst transfer: a randomized controlled trial. (PubMed, Hum Reprod) - P4 | "Our study shows do not support the routine use of intravenous Atosiban to improve pregnancy outcomes among individuals undergoing frozen embryo transfers."

Clinical • Journal • Genetic Disorders

In-silico Approach to Combat Methicillin-resistant Staphylococcus aureus: Targeting RelP Protein with Inhibitor Peptide to Mitigate Drug Resistance. (PubMed, Curr Drug Discov Technol) - "Peptide therapeutics is a novel approach researchers are presently exploring as it pro-vides prompt significant results and promotes a new insight towards dealing with conditions like MDR. Pantocin wh-1 is a peptide drug currently listed as an accessible anti-tuberculosis peptide, and this study suggests the repurposing of this drug as a viable treatment option for MRSA infections."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

ROLE OF ATRIAL NATRIURETIC PEPTIDE AND OXYTOCIN IN GASTRIC EMPTYING DELAY INDUCED BY RIGHT ATRIAL STRETCH IN RATS. (PubMed, Am J Physiol Regul Integr Comp Physiol) - "One week later, rats were randomly subjected for pretreatment with NaCl 0.15 M (control), atosiban (AT, OT-antagonist), anantin (ANT, ANP-antagonist), or dexamethasone (DEX). In turn, oxytocin treatment decreased GE and increased plasma ANP, OT and CORT levels, while AT, ANT and DEX prevented OT-induced GE delay. Hence, AS delayed GE of liquid in rats, a phenomenon that involves oxytocinergic pathways and ANP activity."

Journal • Preclinical • Cardiovascular • Gastrointestinal Disorder

Combination of rTMS and oxytocin agonist attenuate depression-like behavior after postpartum depression in mice. (PubMed, Brain Res) - "Oxytocin acetate (agonist) and atosiban (antagonist) were administered by injection twice daily for three consecutive days following the model according to the established protocol...Nonetheless, OTA therapy followed by rTMS did not exhibit the same pattern of outcomes. Our findings indicate that the combination of rTMS stimulation and an oxytocin agonist in a PPD model may mitigate depression-like behavior."

Journal • Preclinical • CNS Disorders • Depression • Insomnia • Major Depressive Disorder • Mental Retardation • Mood Disorders • Postpartum Depression • Psychiatry • Sleep Disorder • DLG4 • SYP

De novo design of ribosomally synthesized and post-translationally modified peptides. (PubMed, Nat Chem) - "Using a pipeline to evaluate more than 1,000 peptides, the model was parameterized under uniform conditions in Escherichia coli for enzymes from different classes (graspetide, spliceotide, pantocin, cyanobactin, glycocin, lasso peptide and lanthipeptide)...Empirically, RiPPs with the desired modifications constituted 7-67% of the total peptides produced, and 6 of our 8 peptide designs were successfully modified. This work is an example of the design of enzyme-modified peptides and libraries, using a framework that can be expanded to include new enzymes and chemical moieties."

Journal

Integrating Bulk RNA and Single-Cell RNA Sequencing Identifies and Validates Lactylation-Related Signatures for Intervertebral Disc Degeneration. (PubMed, J Cell Mol Med) - "In conclusion, the lactylation correlates positively with IVDD and the LRG signature could be used as a biomarker for the effective clinical treatment of IVDD. CBX3 emerged as one of the key LRGs in IVDD, and atosiban acetate, as a specific inhibitor for CBX3, may be a promising therapeutic candidate for IVDD by affecting lactylation."

Biomarker • Journal • CBX3

Intranasal oxytocin alleviates postsurgical pain and comorbid anxiety in mice: Participation of BK(Ca) channels in the hippocampus. (PubMed, Neuropharmacology) - "Intranasal OXT significantly ameliorated this postsurgical pain and associated anxiety in a dose-dependent manner, while Intra-CA3 microinjection of OTR antagonist atosiban or the BK(Ca) channel blocker paxilline reduced the effect of OXT in incisional mice...Conversely, intra-CA3 microinjection of BK(Ca) channel blocker paxilline in normal mice was sufficient to evoke mechanical pain hypersensitivity. Taken together, our data suggested that intranasal OXT administration exerted analgesic and anxiolytic effects in incisional mice by opening BK(Ca) channels in the CA3 subregion of hippocampus."

Journal • Preclinical • Immunology • Mood Disorders • Pain • Psychiatry • CA3

Oxytocin Protects Against Corticosterone-Induced DA Dysfunction: An Involvement of the PKA/CREB Pathway. (PubMed, Neurochem Res) - "In addition, the neuroprotective effect of OXT was abolished by atosiban (an OXT receptor antagonist) or H89 (a PKA inhibitor). Our results suggest that OXT protects dopaminergic neuroblastoma cells from CORT-induced DA dysfunction, potentially through the involvement of oxytocin receptors and the PKA/CREB signaling pathway. These findings contribute to the understanding of the neurobiological mechanisms underlying stress resilience and highlight potential pathways for developing targeted treatments that leverage the neuroprotective properties of OXT to address disorders characterized by DA dysregulation and impaired stress responses."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • CNS Tumor • Depression • Genetic Disorders • Mental Retardation • Mood Disorders • Neuroblastoma • Oncology • Psychiatry • Schizophrenia • Solid Tumor • Substance Abuse

Tocolysis and Neurodevelopment of Children Born Very Preterm. (PubMed, JAMA Netw Open) - "From modified Poisson regression with propensity score matching, the risk of overall neurodevelopmental disabilities (mild, moderate, or severe) at 5.5 years did not differ between preterm children exposed and not exposed to tocolytics (relative risk [RR], 1.11; 95% CI, 0.85-1.45; P = .44) or in preterm infants exposed to atosiban compared with those exposed to CCBs (RR, 0.94; 95% CI, 0.67-1.32; P = .71). In this study, tocolytics were not associated with neurodevelopmental disabilities among very preterm children surviving at 5.5 years."

Journal • Cerebral Palsy • CNS Disorders • Developmental Disorders • Psychiatry

Drug-induced hyponatraemia and possible related signals: Analysis of 659 cases reported to the Spanish Pharmacovigilance System and disproportionality analysis. (PubMed, Med Clin (Barc)) - "There are increasing reports of drug-induced hyponatraemia. It can be serious and seems to most often affect women over 65 years of age who take more than 1 medication. The time to onset varies and can be very long, so patient monitoring should be continuous throughout treatment. Hydrochlorothiazide is the drug with the highest number of reported cases in our setting. In terms of disproportionate reporting, diuretics leads the list, followed by antiepileptics as oxcarbazepine and eslicarbazepine. Safety signals were found for several drugs, more plausibly for pregabalin and paliperidone, thus a possible association between these drugs and hyponatraemia/SIAD is identified. This signal must be further studied. Meanwhile healthcare professionals should pay attention to this possibility. The reporting of suspected ADRs is essential to understand the risks associated with medicines once they are on the market."

Adverse events • Journal • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Rheumatology

Effects of nationwide adjustment of tocolysis protocol in the Netherlands on neonatal outcomes in women with threatened preterm birth and delivery at 30-32 weeks of gestation: A cohort study. (PubMed, Eur J Obstet Gynecol Reprod Biol X) - "Tocolytic therapy consisted of either nifedipine or atosiban. There was no significant difference in composite neonatal outcome in pregnancies resulting in spontaneous PTB between 30 and 32 weeks of gestation in 2018 (with tocolysis) compared to 2020 (no tocolysis). These results support the protocol adjustment to withhold tocolytic treatment in women with threatened PTB above 30 weeks of gestation."

Journal • Gastrointestinal Disorder • Hematological Disorders • Retinal Disorders • Retinopathy of Prematurity