adapalene / Generic mfg. - LARVOL DELTA

Comparative efficacy of clindamycin phosphate with benzoyl peroxide versus clindamycin phosphate with adapalene in acne vulgaris: a systematic review and meta-analysis. (PubMed, Sci Rep) - "CLIN/BPO also resulted in fewer application site side effects (OR = 0.33, 95% CI: 0.23-0.47, p < 0.001). However, no significant differences were observed between the groups for reducing inflammatory (MD = 1.34,"

Clinical • Journal • Retrospective data • Review • Acne Vulgaris • Dermatology

Targeting the RARα-Gankyrin-PI3K axis with retinoid analogs to modulate autophagy in breast cancer cells: Computational insights and experimental validation. (PubMed, Comput Biol Chem) - "In addition, it suppressed lysosomal activity by 2.73-fold in MCF7 and 2.52-fold in MDA-MB-468, as demonstrated by lysotracker assays. These findings underscore the potential of Adapalene as a multi-targeted modulator of RARα-PI3K signaling, effectively disrupting autophagy and cancer cell survival mechanisms in luminal and triple-negative breast cancer cells."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • PIK3CA • RARA

Importance of Carnitine in Dermatology (CDA 2025) - "Topically, carnitine has shown efficacy in reducing sebum, decreasing hyperpigmentation post- laser treatment, improving skin tolerability with adapalene in acne, reducing acne severity, and enhancing quality of life...Orally, carnitine has proven effective in reducing inflammation, alleviating isotretinoin-related liver and muscle effects, easing muscle spasms in vismodegib patients, countering wasting in pemphigus vulgaris during glucocorticoid therapy, and improving adipocytokines, mental health and inflammatory markers in PCOS. It has also shown benefits in preventing cardiomyopathy progression in severe recessive dystrophic epidermolysis bullosa, reducing advanced glycation end products, and improving walking distance and ulcer healing in peripheral vascular disease. Conclusion Carnitine and its derivatives have therapeutic potential in dermatology, offering benefits both topically and orally, warranting further exploration of their clinical applications."

Acne Vulgaris • Atopic Dermatitis • Cardiomyopathy • Cardiovascular • Complement-mediated Rare Disorders • Dermatitis • Dermatology • Fibrosis • Hereditary Angioedema • Immunology • Infectious Disease • Melanoma • Metabolic Disorders • Pemphigus Vulgaris • Peripheral Arterial Disease • Polycystic Ovary Syndrome • Primary Immunodeficiency • Pruritus • Psoriasis • Sarcoidosis • Scleroderma • Solid Tumor • Systemic Sclerosis

Efficacy, Safety Profile, and Post-Acne Sequelae of 0.025% Retinoic Acid Cream vs. 0.1% Adapalene Cream in Mild Acne Vulgaris in Fitzpatrick Skin Types III-V (clinicaltrials.gov) - P1/2 | N=23 | Completed | Sponsor: Indonesia University

New P1/2 trial • Acne Vulgaris • Dermatology

Comparison of Effectiveness of Topical Retinoids Versus Liquid Nitrogen in Treatment of Plantar Warts(Viral Infection) (clinicaltrials.gov) - P4 | N=98 | Recruiting | Sponsor: Khyber Teaching Hospital

New P4 trial • Dermatology • Infectious Disease

Causes of drug-induced photosensitivity: an analysis using FDA adverse event reporting system database. (PubMed, Sci Rep) - "Immunosuppressants and monoclonal antibodies show mild trends in DIP occurrence. Additionally, adalimumab, adapalene, secukinumab, and fingolimod are novel drug signals of DIP."

Adverse events • Journal • Oncology

Dendrobium polysaccharide-based microneedles loaded with Celosia cristata flavonoids and adapalene nanoparticles for efficacious treatment of acne vulgaris. (PubMed, Int J Biol Macromol) - "In vivo studies using a P. acnes-induced mice model demonstrated that this microneedle system effectively reduced skin swelling, inhibited bacterial growth, and decreased inflammatory cell numbers in the skin. The use of bioactive DOP as a microneedle matrix, combined with sustained-release technology, provides a multifaceted and synergistic approach to acne treatment."

Journal • Acne Vulgaris • Dermatology • Inflammation

Indole-Quinoline Transmutation Enabled by a Formal Rhodium Carbynoid. (PubMed, Angew Chem Int Ed Engl) - "Potential applications in the late-stage skeletal editing of pharmaceutical and natural product derivatives, preparation of adapalene analogs, scaled-up synthesis, and transformations of products are highlighted. Finally, a computational study was conducted to support the envisioned mechanism."

Journal

A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne (clinicaltrials.gov) - P4 | N=20 | Completed | Sponsor: Sun Pharmaceutical Industries Limited | Active, not recruiting ➔ Completed

Trial completion • Acne Vulgaris • Dermatology

A Clinical Study of the Efficacy and Safety of Compound Acids in the Treatment of Mild to Moderate Acne (ChiCTR) - P=N/A | N=48 | Completed | Sponsor: Affiliated Hospital of Jiangsu University; Affiliated Hospital of Jiangsu University

New trial • Acne Vulgaris

Single Cell Fixed RNA Profiling reveals Hepatocytes (Cyp2e1+Cyp1a2+Tnx1+) drives liver fibrosis regression via retinoic acid receptor responder 2 (APASL 2025) - "Pharmacological induction of RARRES1/2 expression in human hepatic stellate cells (HHSteCs) using all-trans retinoic acid, adapalene, bexarotene, or tazarotene dose-dependently suppressed HSC activation by downregulating COL1A1 and α-SMA expression. This study uncovered previously unrecognized molecular and cellular mechanisms of hepatocytes in liver fibrosis regression, identifying RARRES2 as a potential biomarker and therapeutic target for antifibrotic treatment. Table and Figure:Figure 1. Figure 2."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • COL1A1 • CYP1A2 • CYP2E1 • RARRES1 • RARRES2 • TGFB1

ETHNIC: Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients (clinicaltrials.gov) - P3 | N=420 | Recruiting | Sponsor: Centre Hospitalier Universitaire de Nice | Not yet recruiting ➔ Recruiting | Initiation date: Mar 2025 ➔ Jul 2025

Enrollment open • Trial initiation date • Acne Vulgaris • Dermatology

A Disproportionality Analysis on Benzoyl Peroxide and its Risk of Malignancy using the FDA Adverse Event Reporting System. (PubMed, J Invest Dermatol) - No abstract available

Adverse events • Journal • Acne Vulgaris • Oncology

Clascoterone stability when combined with topical acne medications (AAD 2025) - " Tretinoin cream 0.025%, adapalene gel 0.3%, dapsone gel 7.5%, azelaic acid 15%, BP 5%/clindamycin 1%, BP 2.5%/adapalene 0.1%, and encapsulated BP 5% (0.5 mL each) were placed on individual microscope slides with 0.5 mL of clascoterone cream 1% and incubated for 8 hours at 37°C. Clascoterone demonstrated consistent and reproducible stability in the presence of other topical acne medications."

Acne Vulgaris • Dermatology

Cleanse, Treat, Moisturize, Protect (CTMP®) regimen: Enhancing skin quality and treatment outcomes in acne and sensitive skin (AAD 2025) - "Retinoids, such as adapalene, tretinoin, tazarotene, and trifarotene, are considered fundamental topical acne treatments as they target multiple disease aspects (5), and are frequently studied with regimens of cleansers, moisturizers, and protection (6-11). The review also found that combined drug treatments (e.g., topical trifarotene or other retinoids) and corrective procedures (e.g., fillers) may provide optimal treatment outcomes and satisfaction for some patients (21). Overall, the narrative review found that CTMP® may improve adherence, treatment outcomes, patient satisfaction, and overall skin quality in patients with acne and/or sensitive skin."

Clinical • Acne Vulgaris

Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids. (PubMed, Dermatol Ther (Heidelb)) - "Adapalene, tretinoin and tazarotene have demonstrated efficacy in reducing acne and acne sequelae in several studies. Finally, management of acne and acne sequelae should include maintenance therapy with topical retinoids. This article supports the American Academy of Dermatology's call for acne sequelae treatment guidance and emphasizes the need for continued research to optimize patient care."

Journal • Acne Vulgaris • Dermatology

Adapalene potentiates the cytotoxicity of anti-cancer drugs by enhancing cell cycle dysregulation and apoptosis in MKN-45 cells. (PubMed, Toxicol Res (Camb)) - "Adapalene did not show significant cytotoxicity toward AGS and MKN-45 cells, but displayed synergistic or additive effects in inhibiting cell growth and increasing apoptosis in MKN-45 cells, but not AGS cells, when combined with 5-FU, cisplatin, docetaxel, or doxorubicin...Our present results reveal that adapalene is not cytotoxic towards MKN-45 gastric cancer cells when applied alone, but can synergistically enhance the sensitivity of these cells to conventional chemotherapeutic drugs. Further investigations are warranted to fully elucidate the mechanisms underlying the synergistic effects of adapalene and identify markers that could, given the heterogeneity of gastric cancers, identify patients who are likely to benefit from adapalene co-treatment."

Journal • Dermatology • Gastric Adenocarcinoma • Gastric Cancer • Oncology • Solid Tumor • CDKN1A • RAD51 • XPC

Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model. (PubMed, Int J Nanomedicine) - "In vivo testing and histopathological analysis demonstrated that the CAM-BE hydrogel significantly inhibited swelling in the rat auricle, compared to both the free CAM hydrogel and adapalene hydrogel. With their strong anti-inflammatory properties and improved skin penetration, binary ethosomes could be a viable new CAM delivery method. The new formulation was therefore seen as quite promising."

Journal • Preclinical • Acne Vulgaris

The Efficacy and Mechanisms of Fire Needling and 30% Salicylic Acid in the Treatment of Common Acne (ChiCTR) - P=N/A | N=80 | Sponsor: the Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University; the Department of Dermatology, the Second Affiliated Hospi

New trial • Acne Vulgaris

The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study. (PubMed, Clin Cosmet Investig Dermatol) - "Isotretinoin use and papules acne were associated with increased risk of acne complications. While adapalene gel was protective against acne scarring only. This retrospective study sheds light on factors influencing acne scarring and PIH among Acne Vulgaris patients. Our findings provide valuable insights for tailoring interventions and advancing our understanding of acne vulgaris complications in the future."

Biomarker • Journal • Retrospective data • Acne Vulgaris • Dermatology

The role of topical adapalene as an add-on therapy for pityriasis versicolor: a pooled analysis of randomized controlled trials. (PubMed, Arch Dermatol Res) - No abstract available

Journal • Retrospective data

The Effectiveness and Safety of Cleanser Containing Triethyl Citrate, Pyruvic Acid, Combination Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Salicylic Acid 0,5%, Zinc Lactate, Hyaluronic Acid and Spot Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Honokiol (clinicaltrials.gov) - P3 | N=102 | Not yet recruiting | Sponsor: Dr.dr.Irma Bernadette, SpKK (K)

New P3 trial • Acne Vulgaris • Dermatology

ETHNIC: Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients (clinicaltrials.gov) - P3 | N=420 | Not yet recruiting | Sponsor: Centre Hospitalier Universitaire de Nice | Initiation date: Dec 2024 ➔ Mar 2025

Trial initiation date • Acne Vulgaris • Dermatology

Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Reverse Immunosuppressive Tumor Microenvironment. (PubMed, ACS Nano) - "By delivery of adapalene and erastin simultaneously through nanoparticles, the material and energy metabolism of tumor cells can be regulated. This nanoparticle construction achieves tumor tissue targeting and responsive drug release, alters metabolite flow within tumor cells, and effectively kills tumor cells. Additionally, the nanoparticles can reverse the tumor immunosuppressive microenvironment, starting from single-cell regulation to whole-lesion control."

Biomarker • Journal • Tumor microenvironment • Oncology

Efficacy and safety of the novel clindamycin phosphate 1.2%, benzoyl peroxide 3.1%, and adapalene 0.15%. triple combination in treating acne: systematic review and meta-analysis. (PubMed, Arch Dermatol Res) - No abstract available

Journal • Retrospective data • Review • Acne Vulgaris