adapalene / Generic mfg. - LARVOL DELTA

Dendrobium polysaccharide-based microneedles loaded with Celosia cristata flavonoids and adapalene nanoparticles for efficacious treatment of acne vulgaris. (PubMed, Int J Biol Macromol) - "In vivo studies using a P. acnes-induced mice model demonstrated that this microneedle system effectively reduced skin swelling, inhibited bacterial growth, and decreased inflammatory cell numbers in the skin. The use of bioactive DOP as a microneedle matrix, combined with sustained-release technology, provides a multifaceted and synergistic approach to acne treatment."

Journal • Acne Vulgaris • Dermatology • Inflammation

Indole-Quinoline Transmutation Enabled by a Formal Rhodium Carbynoid. (PubMed, Angew Chem Int Ed Engl) - "Potential applications in the late-stage skeletal editing of pharmaceutical and natural product derivatives, preparation of adapalene analogs, scaled-up synthesis, and transformations of products are highlighted. Finally, a computational study was conducted to support the envisioned mechanism."

Journal

A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne (clinicaltrials.gov) - P4 | N=20 | Completed | Sponsor: Sun Pharmaceutical Industries Limited | Active, not recruiting ➔ Completed

Trial completion • Acne Vulgaris • Dermatology

A Clinical Study of the Efficacy and Safety of Compound Acids in the Treatment of Mild to Moderate Acne (ChiCTR) - P=N/A | N=48 | Completed | Sponsor: Affiliated Hospital of Jiangsu University; Affiliated Hospital of Jiangsu University

New trial • Acne Vulgaris

Single Cell Fixed RNA Profiling reveals Hepatocytes (Cyp2e1+Cyp1a2+Tnx1+) drives liver fibrosis regression via retinoic acid receptor responder 2 (APASL 2025) - "Pharmacological induction of RARRES1/2 expression in human hepatic stellate cells (HHSteCs) using all-trans retinoic acid, adapalene, bexarotene, or tazarotene dose-dependently suppressed HSC activation by downregulating COL1A1 and α-SMA expression. This study uncovered previously unrecognized molecular and cellular mechanisms of hepatocytes in liver fibrosis regression, identifying RARRES2 as a potential biomarker and therapeutic target for antifibrotic treatment. Table and Figure:Figure 1. Figure 2."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • COL1A1 • CYP1A2 • CYP2E1 • RARRES1 • RARRES2 • TGFB1

ETHNIC: Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients (clinicaltrials.gov) - P3 | N=420 | Recruiting | Sponsor: Centre Hospitalier Universitaire de Nice | Not yet recruiting ➔ Recruiting | Initiation date: Mar 2025 ➔ Jul 2025

Enrollment open • Trial initiation date • Acne Vulgaris • Dermatology

A Disproportionality Analysis on Benzoyl Peroxide and its Risk of Malignancy using the FDA Adverse Event Reporting System. (PubMed, J Invest Dermatol) - No abstract available

Adverse events • Journal • Acne Vulgaris • Oncology

Clascoterone stability when combined with topical acne medications (AAD 2025) - " Tretinoin cream 0.025%, adapalene gel 0.3%, dapsone gel 7.5%, azelaic acid 15%, BP 5%/clindamycin 1%, BP 2.5%/adapalene 0.1%, and encapsulated BP 5% (0.5 mL each) were placed on individual microscope slides with 0.5 mL of clascoterone cream 1% and incubated for 8 hours at 37°C. Clascoterone demonstrated consistent and reproducible stability in the presence of other topical acne medications."

Acne Vulgaris • Dermatology

Cleanse, Treat, Moisturize, Protect (CTMP®) regimen: Enhancing skin quality and treatment outcomes in acne and sensitive skin (AAD 2025) - "Retinoids, such as adapalene, tretinoin, tazarotene, and trifarotene, are considered fundamental topical acne treatments as they target multiple disease aspects (5), and are frequently studied with regimens of cleansers, moisturizers, and protection (6-11). The review also found that combined drug treatments (e.g., topical trifarotene or other retinoids) and corrective procedures (e.g., fillers) may provide optimal treatment outcomes and satisfaction for some patients (21). Overall, the narrative review found that CTMP® may improve adherence, treatment outcomes, patient satisfaction, and overall skin quality in patients with acne and/or sensitive skin."

Clinical • Acne Vulgaris

Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids. (PubMed, Dermatol Ther (Heidelb)) - "Adapalene, tretinoin and tazarotene have demonstrated efficacy in reducing acne and acne sequelae in several studies. Finally, management of acne and acne sequelae should include maintenance therapy with topical retinoids. This article supports the American Academy of Dermatology's call for acne sequelae treatment guidance and emphasizes the need for continued research to optimize patient care."

Journal • Acne Vulgaris • Dermatology

Adapalene potentiates the cytotoxicity of anti-cancer drugs by enhancing cell cycle dysregulation and apoptosis in MKN-45 cells. (PubMed, Toxicol Res (Camb)) - "Adapalene did not show significant cytotoxicity toward AGS and MKN-45 cells, but displayed synergistic or additive effects in inhibiting cell growth and increasing apoptosis in MKN-45 cells, but not AGS cells, when combined with 5-FU, cisplatin, docetaxel, or doxorubicin...Our present results reveal that adapalene is not cytotoxic towards MKN-45 gastric cancer cells when applied alone, but can synergistically enhance the sensitivity of these cells to conventional chemotherapeutic drugs. Further investigations are warranted to fully elucidate the mechanisms underlying the synergistic effects of adapalene and identify markers that could, given the heterogeneity of gastric cancers, identify patients who are likely to benefit from adapalene co-treatment."

Journal • Dermatology • Gastric Adenocarcinoma • Gastric Cancer • Oncology • Solid Tumor • CDKN1A • RAD51 • XPC

Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model. (PubMed, Int J Nanomedicine) - "In vivo testing and histopathological analysis demonstrated that the CAM-BE hydrogel significantly inhibited swelling in the rat auricle, compared to both the free CAM hydrogel and adapalene hydrogel. With their strong anti-inflammatory properties and improved skin penetration, binary ethosomes could be a viable new CAM delivery method. The new formulation was therefore seen as quite promising."

Journal • Preclinical • Acne Vulgaris

The Efficacy and Mechanisms of Fire Needling and 30% Salicylic Acid in the Treatment of Common Acne (ChiCTR) - P=N/A | N=80 | Sponsor: the Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University; the Department of Dermatology, the Second Affiliated Hospi

New trial • Acne Vulgaris

The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study. (PubMed, Clin Cosmet Investig Dermatol) - "Isotretinoin use and papules acne were associated with increased risk of acne complications. While adapalene gel was protective against acne scarring only. This retrospective study sheds light on factors influencing acne scarring and PIH among Acne Vulgaris patients. Our findings provide valuable insights for tailoring interventions and advancing our understanding of acne vulgaris complications in the future."

Biomarker • Journal • Retrospective data • Acne Vulgaris • Dermatology

The role of topical adapalene as an add-on therapy for pityriasis versicolor: a pooled analysis of randomized controlled trials. (PubMed, Arch Dermatol Res) - No abstract available

Journal • Retrospective data

The Effectiveness and Safety of Cleanser Containing Triethyl Citrate, Pyruvic Acid, Combination Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Salicylic Acid 0,5%, Zinc Lactate, Hyaluronic Acid and Spot Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Honokiol (clinicaltrials.gov) - P3 | N=102 | Not yet recruiting | Sponsor: Dr.dr.Irma Bernadette, SpKK (K)

New P3 trial • Acne Vulgaris • Dermatology

ETHNIC: Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients (clinicaltrials.gov) - P3 | N=420 | Not yet recruiting | Sponsor: Centre Hospitalier Universitaire de Nice | Initiation date: Dec 2024 ➔ Mar 2025

Trial initiation date • Acne Vulgaris • Dermatology

Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Reverse Immunosuppressive Tumor Microenvironment. (PubMed, ACS Nano) - "By delivery of adapalene and erastin simultaneously through nanoparticles, the material and energy metabolism of tumor cells can be regulated. This nanoparticle construction achieves tumor tissue targeting and responsive drug release, alters metabolite flow within tumor cells, and effectively kills tumor cells. Additionally, the nanoparticles can reverse the tumor immunosuppressive microenvironment, starting from single-cell regulation to whole-lesion control."

Biomarker • Journal • Tumor microenvironment • Oncology

Efficacy and safety of the novel clindamycin phosphate 1.2%, benzoyl peroxide 3.1%, and adapalene 0.15%. triple combination in treating acne: systematic review and meta-analysis. (PubMed, Arch Dermatol Res) - No abstract available

Journal • Retrospective data • Review • Acne Vulgaris

A prospective, double-blinded, randomized head-to-head clinical trial of topical adapinoid (oleyl adapalenate) versus retinol. (PubMed, Skin Health Dis) - P=N/A | "Overall, the use of OA as a precursor to adapalene may be an effective method to improving the tolerability of retinoids while maintaining efficacy. This study was registered on www.clinicaltrials.gov (NCT05778760)."

Clinical • Head-to-Head • Journal • Dermatology

Photosensitizing Properties of the Topical Retinoid Drug Adapalene. (PubMed, Chem Res Toxicol) - "Interestingly, quenching of the adapalene singlet manifold by oxygen leads to an increased production of this reactive oxygen species through the tagged O2-enhanced intersystem crossing process. Taken together, these results are relevant from a toxicological point of view as adapalene could be considered as a double-edged sword: it can be at the origin of undesired skin photosensitivity reactions or be considered as a candidate for topical photodynamic therapy."

Journal • Acne Vulgaris

One Acne™: a holistic management approach to improve overall skin quality and treatment outcomes in acne with or without sensitive skin. (PubMed, Int J Dermatol) - "Tretinoin, trifarotene, adapalene, and tazarotene have all been assessed in clinical studies for managing acne-associated scarring, with varying success, with the latter three reported to improve skin quality. This narrative review highlights that comprehensive skincare regimens should be used throughout acne patients' journeys to reduce treatment-related irritation, improve treatment outcomes, adherence, and satisfaction, and enhance overall skin quality. Patients with sensitive skin should choose tailored skincare products to maintain skin barrier integrity and restore skin function."

Journal • Review • Acne Vulgaris • Dermatology

Multiple pelvic condylomatous masses in an African child (ASTMH 2024) - "Adapalene, 0.1% cream, was prescribed, and the smallest 0.5 cm masses were entirely resolved after several weeks...While treatment for aggressive forms of KS with paclitaxel and liposomal doxorubicin is the first-line therapy, due to unaffordability, a third-generation retinoid was prescribed...African Endemic KS is often a forgotten subtype that garners little attention and manifests with significant morbidity and mortality. It is hoped that governments can collaborate with pharmaceutical companies to make chemotherapeutic drugs available at low or no cost to treat this often fatal malignancy."

Clinical • Epstein-Barr Virus Infections • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Kaposi Sarcoma • Oncology • Sarcoma • Solid Tumor

Pulse Activation of Retinoic Acid Receptor Enhances Hematopoietic Stem Cell Homing by Controlling CXCR4 Membrane Presentation. (PubMed, Stem Cell Rev Rep) - "In this study, we identify and characterize the role of adapalene (ADA), a retinoic acid receptor (RAR) agonist, in modulating the migration behavior of hematopoietic stem cells (HSCs). Our initial findings reveal that ADA treatment suppresses hematopoietic stem and progenitor cell (HSPC) mobilization induced by AMD3100 and G-CSF...Additionally, competitive transplantation assays indicate a marked increase in donor chimerism following ADA treatment. These findings highlight the critical role of retinoic acid signaling in regulating HSC homing and suggest its potential for advancing novel HSC-based therapeutic strategies."

Journal • Transplantation • CXCL12 • CXCR4

Microemulsion-based topical hydrogels containing lemongrass leaf essential oil (Cymbopogon citratus (DC.) Stapf) and mango seed kernel extract (Mangifera indica Linn) for acne treatment: Preparation and in-vitro evaluations. (PubMed, PLoS One) - "Finally, the anti-inflammatory activities of the hydrogel, using heat-induced BSA denaturation assay and LPS-stimulated RAW 264.7 NO inhibition assay, was 4-times higher than that of the reference drug Klenzit-C® (adapalene and clindamycin gel). Moreover, the hydrogel possessed strong anti-biofilm activity in Cutibacterium acnes, comparable with Klenzit-C®. Conclusively, the microemulsion-based hydrogel containing lemongrass oil and mango seed extract demonstrated much potentials to be a promising natural drug for acne treatment."

Journal • Preclinical • Acne Vulgaris