apixaban / Generic mfg. - LARVOL DELTA

Apixaban for Cancer-Associated Venous Thromboembolism. (PubMed, N Engl J Med) - No abstract available

Journal • Cardiovascular • Oncology • Venous Thromboembolism

Apixaban for Cancer-Associated Venous Thromboembolism. (PubMed, N Engl J Med) - No abstract available

Journal • Cardiovascular • Oncology • Venous Thromboembolism

Splenic Infarction at the Crossroads of Hematologic and Cardioembolic Risk. (PubMed, Cureus) - "She was treated with intravenous fluids, analgesia, and anticoagulation; initially with heparin infusion, later transitioned to apixaban. Concurrently, disease-directed therapy with asciminib and hydroxyurea led to a partial hematologic response...It underscores the importance of timely imaging for diagnosis and the delicate balance of anticoagulation in the setting of malignancy-associated thrombocytosis. Individualized, multidisciplinary management and careful long-term follow-up are essential to optimize outcomes in this complex patient population."

Journal • Atrial Fibrillation • Cardiovascular • Chronic Myeloid Leukemia • Hematological Disorders • Hematological Malignancies • Hypertension • Leukemia • Oncology • Pain • Thrombocytosis • Thrombosis • ABL1 • BCR

Apixaban for Cancer-Associated Venous Thromboembolism. (PubMed, N Engl J Med) - No abstract available

Journal • Cardiovascular • Oncology • Venous Thromboembolism

Apixaban for Cancer-Associated Venous Thromboembolism. Reply. (PubMed, N Engl J Med) - No abstract available

Journal • Cardiovascular • Oncology • Venous Thromboembolism

Apixaban for Cancer-Associated Venous Thromboembolism. (PubMed, N Engl J Med) - No abstract available

Journal • Cardiovascular • Oncology • Venous Thromboembolism

Venous Thromboembolism Therapy with Edoxaban in Daily Care Patients: Results from the DRESDEN NOAC REGISTRY. (PubMed, TH Open) - "At 6 months, 78.2% were still taking edoxaban, 2% were electively switched to dose-reduced secondary prophylaxis with apixaban 2.5 mg twice a day or rivaroxaban 10 mg once daily. Our results indicate effectiveness of edoxaban in acute VTE treatment with excellent persistence in the treatment and low rates of unplanned discontinuation. Bleeding was frequently observed, but rates of major bleeding were low and comparable to phase III data."

Journal • Cardiovascular • Hematological Disorders • Respiratory Diseases • Venous Thromboembolism

Thyrotoxicosis as a Potential Contributor to Cerebral Venous Thrombosis (ENDO 2025) - "No evidence of intracranial hemorrhage, infarction, or increased intracranial pressure was found.She was admitted to the ICU and started on IV heparin...She was initially started on propylthiouracil (PTU) 200 mg three times a day, cholestyramine three times a day and hydrocortisone...She was transitioned to apixaban 5 mg twice daily for ongoing anticoagulation prior to discharge and methimazole 30 mg daily.ConclusionAlthough rare, CVT can be a presenting complication of thyrotoxicosis. Given the high prevalence of thyroid disorders, particularly in women, clinicians should consider thyroid dysfunction as a potential contributing factor in CVT cases. Early detection and treatment of thyrotoxicosis can reduce the risk of life-threatening thrombotic events."

Late-breaking abstract • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Endocrine Disorders • Grave’s Disease • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Migraine • Mood Disorders • Pain • Thrombosis

Severe Hypothyroidism with Impending Myxedema Coma after Pembrolizumab Therapy (ENDO 2025) - "This is the case of a 72 y/o male with history of hypertension, atrial fibrillation on apixaban and amiodarone, chronic obstructive pulmonary disease GOLD 2A, hyperlipidemia, chronic kidney disease stage 2, seizures, oropharyngeal dysphagia, and stage IV lung squamous cell carcinoma with metastasis to the brain that failed to conventional therapy and was started on pembrolizumab 6 weeks ago...Patient was initially managed with IV bolus of hydrocortisone 100 mg and then started on IV levothyroxine (100 mcg once then 50 mcg daily) and Hydrocortisone IV drip for 3 days...The occurrence of anti-PD-1–induced thyroid irAEs is high, although the underlying mechanism is not completely understood. Therefore, it is important to monitor thyroid function test closely in patients receiving these therapies for prompt recognition and treatment."

Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • CNS Disorders • Dyslipidemia • Endocrine Disorders • Epilepsy • Gastrointestinal Disorder • Heart Failure • Hypertension • Immunology • Nephrology • Non Small Cell Lung Cancer • Oncology • Otorhinolaryngology • Pulmonary Disease • Renal Disease • Respiratory Diseases

A Rare Case of Spontaneous Thyroid Hemorrhage Related to Anticoagulation Use and Multinodular Goiter (ENDO 2025) - "Apixaban was discontinued...Anticoagulation was stopped subsequently in another three months and aspirin was initiated...Cases of thyroid hemorrhage related to warfarin use have been reported in literature...Conservative management with serial imaging is appropriate, especially in the absence of airway symptoms. While fine needle aspiration may be considered, surgical evacuation is required for expanding hematomas or persistent respiratory symptoms."

Clinical • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammatory Arthritis • Ischemic stroke • Otorhinolaryngology • Pain • Rheumatoid Arthritis • Rheumatology

"From GI Origin to Multisystem Metastasis: A Case of Advanced Carcinoid Syndrome" (ENDO 2025) - "Despite initial treatment with lanreotide and everolimus, adherence was poor due to fear of side effects...Management included a heparin drip for splenic infarct (later switched to Eliquis), oseltamivir for influenza, and supportive care...ConclusionCarcinoid tumors are rare, slow-growing malignancies with less aggressive biology than noncarcinoid tumors. Treatment aims to cure localized disease or palliate symptoms in advanced cases, with early palliative care integration essential for improving quality of life."

Clinical • Metastases • Carcinoid Syndrome • Cardiovascular • Chronic Kidney Disease • Colorectal Cancer • Diabetes • Diabetic Nephropathy • Endocrine Cancer • Fibrosis • Gallbladder Cancer • Gastrointestinal Disorder • Hepatocellular Cancer • Hepatology • Hypotension • Immunology • Infectious Disease • Influenza • Lung Cancer • Metabolic Disorders • Neuroendocrine Tumor • Oncology • Ophthalmology • Palliative care • Peritoneal Cancer • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • Solid Tumor • Type 2 Diabetes Mellitus • SSTR

Unilateral Adrenal Hemorrhage in a Patient on Anticoagulation for Atrial Fibrillation: A Rare Case (ENDO 2025) - "We report the case of a 71-year-old female with paroxysmal atrial fibrillation (AF) who developed acute right upper quadrant pain five days after initiating apixaban...Maintaining a high index of suspicion for adrenal hemorrhage in patients with acute abdominal pain and recent anticoagulant use is critical, as prompt intervention can prevent life-threatening complications. The successful resolution of this case emphasizes the importance of close monitoring, collaboration across specialties, and careful evaluation of the risks and benefits of anticoagulation resumption."

Clinical • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Nephrology • Oncology • Pain • Renal Disease

The Intersection of Obesity, Testosterone Therapy, and Atrial Fibrillation: A Case Report (ENDO 2025) - "Clinical case: A 22-year-old male with a history of well-controlled diabetes mellitus (managed with Ozempic) and chronic back pain (treated with Belbuca and hydrocodone-acetaminophen) presented with palpitations and chest pain...In the emergency department, he was found to be in atrial fibrillation with Afib RVR at a heart rate of bpm, refractory to oral diltiazem but controlled with a continuous diltiazem infusion, reducing his heart rate to the 80s...Patient started on 75mg metoprolol for rate control and eliquis for stroke prevention... This case highlights the need for careful management of young patients with a complex medical history involving exogenous testosterone therapy, opioid use, and obesity. Clinicians should be vigilant in monitoring cardiovascular health and considering the risks of erythrocytosis in patients on testosterone therapy. Further research is needed to better understand the mechanisms linking hormonal therapy, erythrocytosis, and arrhythmias."

Case report • Clinical • Atrial Fibrillation • Back Pain • Cardiovascular • Diabetes • Genetic Disorders • Hematological Disorders • Infectious Disease • Metabolic Disorders • Musculoskeletal Pain • Obesity • Pain

Navigating Pericardial Tamponade in a Patient with Multiple Comorbidities (ASA 2025) - "Notably, she had eaten a full meal five hours prior and had taken apixaban and empagliflozin that morning. Bedside echocardiogram confirmed a large pericardial effusion, right atrial collapse, and interventricular septal flattening. Anesthetic management was challenging and required careful consideration of anticoagulation reversal, aspiration prevention, hemodynamic stability, and adequate analgesia during this emergent procedure."

Clinical • Anesthesia • Breast Cancer • Congestive Heart Failure • Heart Failure • Oncology • Pulmonary Embolism • Solid Tumor • Thrombosis

NOACs for VTE prevention in patients with lower limb fracture: a systematic review and meta-analysis. (PubMed, J Orthop Surg Res) - "Compared with LMWH, NOACs were associated with a lower risk of DVT in patients with lower limb fractures, although there was no statistically significant difference in preventing VTE, PE and major bleeding."

Journal • Retrospective data • Review • Cardiovascular • Hematological Disorders • Musculoskeletal Diseases • Orthopedics • Respiratory Diseases • Venous Thromboembolism

Ketamine cholangiopathy: largest UK single-centre case series reporting clinical outcomes in 36 patients (BSG 2025) - "Patient with PT 18.7s was taking apixaban.HBV, HCV, HIV, and IgG-4 status was checked in 25, 27, 19, and 7 patients respectively. Bladder dysfunction was highly prevalent in our cohort.To our knowledge this is the largest UK single-centre case series reporting clinical outcomes in ketamine-induced cholangiopathy. A high index of suspicion is required for ketamine as an aetiology in cases of unexplained deranged liver bloods with or without radiological changes, particularly in younger people"

Clinical • Clinical data • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Urology

The Safety of Apixaban Compared to Warfarin in Hospitalized Patients with Acute Kidney Injury. (PubMed, J Clin Med) - "Readmission rates were comparable (38.8% for apixaban vs. 39.7% for warfarin; p = 0.9499). In hospitalized AKI patients, apixaban was associated with a lower major bleeding risk compared to warfarin, with similar rates of thrombotic events, mortality, and readmissions, suggesting apixaban may be a safer option, warranting further research."

Journal • Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Hematological Disorders • Nephrology • Renal Disease • Venous Thromboembolism

Saddle Pulmonary Embolism with Right Heart Strain in Patient Presenting for Spinal Decompression for Cauda Equina Syndrome (ASA 2025) - "His neurologic symptoms then resolved. He was discharged on Apixaban."

Clinical • Back Pain • Cardiovascular • Hypotension • Musculoskeletal Pain • Pain • Pulmonary Embolism • Respiratory Diseases

Difficult airway in a patient with multiple co-morbidities for a difficult neurosurgical procedure (ASA 2025) - "A 71-year-old with metastatic tonsillar squamous cell carcinoma (status-post radiation and prior tracheostomy), chronic obstructive pulmonary disease (home oxygen), and atrial fibrillation (apixaban), presented with an unstable C2/odontoid fracture due to metastatic disease...The patient underwent a unique awake fiberoptic technique prior to safe and successful surgery. This case highlights the importance of thorough assessment of candidacy for awake fiberoptic intubation, as well as multidisciplinary approach and expert involvement in planning of complex airway management."

Clinical • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Musculoskeletal Diseases • Oncology • Pulmonary Disease • Respiratory Diseases • Squamous Cell Carcinoma

Balancing Bleeding Risk and Embolic Threat: A Multidisciplinary Approach to Urgent Hip Fracture Surgery (ASA 2025) - "A 90-year-old female with heart failure with reduced ejection fraction (HFrEF) and left ventricular thrombus on apixaban presented with a left hip fracture requiring urgent surgery...A positive common femoral vein DVT scan led to IVC filter placement prior to surgery. Preoperative risk stratification by the anesthesiologist and multidisciplinary collaboration were pivotal in managing anticoagulation, minimizing right heart failure risk, and ensuring safe fracture fixation in this high-risk geriatric patient."

Surgery • Anesthesia • Cardiovascular • Congestive Heart Failure • Geriatric Disorders • Heart Failure • Musculoskeletal Diseases • Orthopedics • Thrombosis

Cardiac Goal Directed Management and Intraoperative Optimization in a patient with Significant CAD for a Free Flap (ASA 2025) - "We present a 69-year-old male with squamous cell carcinoma of the mandible, CAD (subtotal RCA occlusion, 50% mLAD), a 5cm ascending aortic aneurysm, previous CVA, DVT/PE on Eliquis, COPD, and HTN undergoing free flap reconstruction...Intraoperative management, guided by Edwards HPI, titrated inotropes and vasoactive agents to maintain coronary and flap perfusion during a lengthy procedure with significant anesthetic effects. Despite significant hemodynamic challenges, the patient was extubated uneventfully, and the free flap remained viable postoperatively."

Clinical • Anesthesia • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Oncology • Respiratory Diseases • Squamous Cell Carcinoma

The Ticking Time Bomb: Hypercoagulability in the Thoracic Perioperative Window (ASA 2025) - "Further workup discovered BLE DVTs, for which patient was placed on Apixaban...Patient was intubated & bedside TTE highly concerning for PE, for which he was transported to IR for emergent thrombectomy. The patient arrested and was placed on peripheral VA ECMO."

Cough • Infectious Disease • Oncology • Respiratory Diseases

Anesthetic Challenges in a Patient with Myotonic Dystrophy Undergoing Pancreaticoduodenectomy (Whipple Procedure) (ASA 2025) - "We present an 83-year-old male with a complex history of myotonic dystrophy (DM), paroxysmal atrial fibrillation on apixaban, MVP, GERD, PVCs, AV block s/p pacemaker, OSA, BPH, and insomnia. Here we highlight critical perioperative considerations in a DM patient for a major abdominal surgery, which has not been previously described. Notable considerations include using the TIVA with propofol and remifentanil, use of cisatracurium over succinylcholine, truncal regional block, and sugammadex reversal."

Clinical • Anesthesia • Atrial Fibrillation • Biliary Cancer • Cardiovascular • Cholangiocarcinoma • CNS Disorders • Gastroesophageal Reflux Disease • Genetic Disorders • Insomnia • Muscular Dystrophy • Myotonic Dystrophy • Oncology • Pancreatic Cancer • Sleep Disorder • Solid Tumor

Aortic Valve Replacement for Infective Endocarditis Complicated by Heparin-Induced Thrombocytopenia and Intraoperative Pulmonary Shunting (ASA 2025) - "62-year-old man with aortic valve endocarditis presented with embolic limb ischemia requiring thromboembolectomy and fasciotomy.Transthoracic echocardiography revealed severe aortic insufficiency with a mobile valve vegetation, prompting surgical aortic valve replacement.He was initially anticoagulated with heparin, but developed heparin-induced thrombocytopenia with a persistently positive HIT antibody.He was treated for deep vein thrombosis with apixaban, which was bridged for surgery with argatroban infusion.The case proceeded with an intraoperative Flolan protocol to prevent HIT-associated thrombosis during heparin administration for cardiopulmonary bypass. The procedure was complicated by hypoxemia attributed to Flolan-associated pulmonary shunting.This case highlights the perioperative challenges in the setting of HIT and Flolan-associated hemodynamic instability."

Cardiovascular • Hematological Disorders • Thrombocytopenia • Thrombosis

Intraoperative Hemodynamic Collapse in Spine Surgery: A Case of Pulmonary Embolism Mimicking Hemorrhagic Shock (ASA 2025) - "The patient was hemodynamically stable, treated with heparin, transitioned to apixaban, and discharged. This case highlights the diagnostic challenge of intraoperative PE in spine surgery with hemodynamic instability."

Clinical • Surgery • Asthma • Cardiovascular • CNS Disorders • Gastroesophageal Reflux Disease • Hematological Disorders • Hypertension • Hypotension • Immunology • Multiple Sclerosis • Orthopedics • Pulmonary Embolism • Respiratory Diseases