moxifloxacin/ketorolac / Generic mfg. - LARVOL DELTA

Ocular bioanalysis of moxifloxacin and ketorolac tromethamine in rabbit lacrimal matrix using liquid chromatography-tandem mass spectrometry. (PubMed, Bioanalysis) - "Results & An easy, quick and selective method was established and applied to assess the ocular pharmacokinetic profile of a commercially available formulation containing MOXI and KTR. Based on the pharmacokinetic data, this work describes pharmacokinetics-based dosage regimen calculations and their clinical significance."

Journal • Preclinical • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Randomized, Prospective, Observer-Masked Study Comparing Dropless Treatment Regimen Using Intracanalicular Dexamethasone Insert, Intracameral Ketorolac, and Intracameral Moxifloxacin versus Conventional Topical Therapy to Control Postoperative Pain and Inflammation in Cataract Surgery. (PubMed, Clin Ophthalmol) - "In this prospective, contralateral eye study, patients with bilateral cataract were randomized to receive either intracanalicular dexamethasone insert, intracameral phenylephrine 1%/ketorolac 0.3%, and intracameral moxifloxacin (50 µg) (study group) or topical moxifloxacin 0.5%, ketorolac 0.5%, and prednisolone acetate 1.0% QID (control group). A dropless treatment regimen is as effective as topical eyedrop administration. A higher proportion of patients who underwent bilateral cataract surgery preferred the dropless treatment regimen over the patient-administered eye drop regimen."

Clinical • Surgery • Cataract • Inflammation • Ocular Inflammation • Ophthalmology • Pain

Comparative Outcomes of Standard Perioperative Eye Drops, Intravitreal Triamcinolone Acetonide-Moxifloxacin, and Intracameral Dexamethasone-Moxifloxacin-Ketorolac in Cataract Surgery. (PubMed, J Ophthalmol) - "Intravitreal triamcinolone acetonide-moxifloxacin and intracameral dexamethasone-moxifloxacin-ketorolac demonstrate similar levels of efficacy to a standard eye drop regimen after cataract surgery. This study reinforces them as viable alternatives to traditional postoperative drops."

Journal • Cataract • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

[VIRTUAL] Comparative Outcomes of Intravitreal Triamcinolone Acetonide-Moxifloxacin with Intracameral Dexamethasone-Moxifloxacin-Ketorolac in Cataract Surgery (ARVO 2021) - "While triamcinolone acetonide-moxifloxacin demonstrates earlier postoperative inflammatory control compared to dexamethasone-moxifloxacin-ketorolac, both are effective in the postoperative recovery of cataract surgery. Additionally, intravitreal triamcinolone acetonide-moxifloxacin causes a slightly higher but significant IOP compared to intracameral dexamethasone-moxifloxacin-ketorolac. This study reinforces them as viable alternatives to traditional postoperative drops."

Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Ophthalmic organizations request FDA reconsider moxifloxacin removal from 503B bulk list (Healio) - "Several major ophthalmic organizations requested the FDA reconsider its intention to remove moxifloxacin from the 503B bulk drug list, which identifies drug substances for which there is a clinical need....Moxifloxacin and ketorolac are two of 19 bulk drug substances the FDA is considering to not include on the list of active pharmaceutical ingredients....Moxifloxacin can be injected after cataract surgery as an antibiotic prophylaxis, and ketorolac is a common NSAID used preoperatively and postoperatively for ophthalmic procedures."

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