Loss of KLF15 expression characterizes proximal tubule injury in cisplatin-induced acute kidney injury: A multi-omics study. (PubMed, Curr Res Toxicol) - Jun 5, 2026 - "Nephrotoxicity is a common side effect of cisplatin (CSP), a widely-used anti-tumor chemotherapy drug. Furthermore, virtual screening identified 6 drugs, including Simeprevir, Lomitapide, and Avodart, as potential high-affinity compounds targeting human KLF15. In conclusion, our study indicates that the downregulation of KLF15 is a prominent molecular feature in CSP-induced AKI, associated with metabolic failure and injury in proximal tubules."
Journal • Acute Kidney Injury • Nephrology • Oncology • Renal Disease • KLF5
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Dong Wang; Heqing Yang; Lei Chen; Shiying Xie; Shunliang Yang; Xiangshen Liu
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