Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA delivery. (PubMed, bioRxiv) - Jun 5, 2026 - "The resulting lung surfactant-enhanced LNPs (Surf-LNPs) exhibited substantial improvements in particle assembly, yielding an order of magnitude higher particle concentration at equivalent input conditions compared to conventional (Onpattro-like) LNP formulations. In vivo evaluation following intranasal administration further revealed enhanced mCherry expression in the lungs of mice treated with Surf-LNPs compared to conventional LNPs. Ultimately, these findings establish lung surfactant incorporation as a simple yet powerful formulation strategy to improve pulmonary gene delivery using LNPs, with the potential to significantly advance the translation of inhaled nucleic acid therapeutics."
Journal • Genetic Disorders
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Gregg A Duncan; Owen E Tabah; Sahana Kumar; Sarah S Nasr
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