SOS1-RAS-RAF signaling sensitizes platelet responsiveness via GPVI and PAR-1 (ISTH 2026) - May 25, 2026 - Abstract #PB2518; Pres time: Jul 13, 2026; 01:45 PM - 02:45 PM; Location: Exhibition Hall- Poster Area; "At high convulxin and TRAP-6 concentrations, inhibition of SOS1-RAS interaction, (Bay-293), BRAF (PLX4032) or BRAF dimerization (PLX8394) partially reduced platelet αIIbβ3 integrin activation, P-selectin/CD63 surface expression, aggregation and phosphatidylserine exposure in a dose dependent manner...Synergistic inhibition of convulxin-induced platelet activation and MEK1/2 S217/221 phosphorylation was observed by combined blocking of BRAF and PKC isoforms (GF109203X), P2Y 12 receptor (AR-C69931), PI3K-p110β (TGX-221) and ASK1 (selonsertib), respectively...This project was supported by the German Research Foundation (DFG). DOI*10.1016/j.rpth.2026.105258"
ARAF • CD63 • MAP2K1
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Saskia von Ungern-Sternberg 1; Luisa Hastenplug 1; Laura Venohr 1; Yasmin Sedaghat 1; Laura Göbel 1; Jan Luca Dittrich 1; Krishnaraj Rajalingam 2; Ulrich Walter 1; Kerstin Jurk 1
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