Myeloid cell 5-lipoxygenase activation and its metabolite product 5-HETE promote systemic inflammation and hepatocyte ferroptosis in acute-on-chronic liver failure (EASL 2026) - Mar 18, 2026 - Abstract #REG26-719; SAT-501; 719; Pres time: May 30, 2026; 08:30 AM - 04:00 PM; Location: Poster Area - Hall 7; "Oral zileuton was tested in LPS/D-GalN and ConA murine liver failure... Myeloid 5-LOX activation is tightly linked to systemic inflammation and severity in ACLF, and 5-HETE associates with hepatocyte ferroptosis, supporting 5-LOX as a therapeutic target."
Fibrosis • Hepatology • Inflammation • Liver Failure • ATF4
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Huilan Tu1; Xinyi Xu1; Ruoqi Zhou1; Xia Yu1; Xianbin Xu1; Jiyang Chen1; Xiuding Zhang1; Xinxin Liu1; Ying Hu1; Jifang Sheng1; Yu Shi1
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