Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation (ASH 2023) - Nov 3, 2023 - Abstract #3447; Pres time: Dec 10, 2023; 06:00 PM - 08:00 PM; Location: Halls G-H (San Diego Convention Center); "Tacrolimus and sirolimus interact with a distinct immunophilin, FKBP12. KO of PPIA is an effective strategy for engineering resistance to CsA and VCS in cellular therapies. Our results demonstrate that PPIA KO conventional T cells, VSTs, and CAR-T cells were markedly resistant to the otherwise suppressive effects on T cell proliferation that are hallmarks of both CsA and VCS. Engineering CNI-resistance into IECs will enhance the ability to deploy these cells early after transplant to prevent or treat both malignant relapse and viral reactivation."
Glomerulonephritis • Graft versus Host Disease • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Solid Organ Transplantation • Transplantation • CD4 • CD8
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Holly Wobma, MD, PhD1,2; Jiayi Dong, BS1; Francesca Alvarez Calderon1,3; Xianliang Rui, PhD3; Katherine Michaelis, MD, PhD1,3; Bruce R Blazar, MD4; Victor Tkachev, PhD1,5; Ulrike Gerdemann, MD1,3; Leslie Kean1,3
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