Integrative Systems Analysis of Calcineurin Inhibitor Action on Podocytes and Proximal Tubular Epithelial Cells (KIDNEY WEEK 2023) - Oct 15, 2023 - Abstract #SA-PO010; Pres time: Nov 4, 2023; 10:00 AM - 12:00 PM; Location: Exhibit Hall, Pennsylvania Convention Center; "Funding: Commercial Support - AuriniaBackground: Calcineurin inhibitors (CNI), including Cyclosporin A (CSA), Tacrolimus (TAC) and Voclosporin (VCS) are used to treat proteinuric kidney disease. While integrated viability, proteomic and high-content morphometric analyses show a common CNI-induced signature within human proximal tubular epithelial cells and podocytes, differences were observed among CSA, TAC and VCS for both differentially abundant proteins and drug dose responses. Consistent adhesome and cytoskeletal changes may point to a conserved biophysical role of calcineurin in podocytes with differences in off-target effects."
Nephrology • Renal Disease
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Anthony Mendoza1; Maria Paola Santini1; Jenny Wong1; Linda M. Rehaume2; John Viel2; Kirk N. Campbell1; Evren U. Azeloglu1
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