Successful Voclosporin Treatment of Lupus Nephritis in an Adolescent (KIDNEY WEEK 2023) - Oct 15, 2023 - Abstract #FR-PO654; Pres time: Nov 3, 2023; 10:00 AM - 12:00 PM; Location: Exhibit Hall, Pennsylvania Convention Center; "Rituximab (RTX) is a widely employed treatment for children with LN flare, though Its use may be limited by severe hypersensitivity reaction...She was treated with Prednisone and mycophenolate mofetil leading to complete remission...Cyclophosphamide (CYC) was not used due to parental refusal. She remained on hydroxychloroquine, prednisone, enalapril and aspirin.In late 2022, she had a symptomatic LN flare with hypoalbuminemia, edema, and serum creatinine of 0.5mg/dL. Repeat RTX infusion led to a severe hypersensitivity reaction characterized by chest pain, SOB and generalized rash which required epinephrine, antihistamine and O2...With the use of VCS, patient had rapid improvement in her serum albumin and reduction of proteinuria within 2 weeks, which has been maintained to 12 weeks. At last visit her serum albumin improved to 3.3 gm/dL from 2.1gm/dL and UPCR (mg/mg creatinine) improved to 1.4 from 7.5 at the start of VCS. Her lipid profile ( Total cholesterol, LDL,..."
Glomerulonephritis • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pain • Pediatrics • Renal Disease
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Anil K. Mongia1; Basant Hamed1; Maria-Anna Vastardi1; Hilda E. Fernandez2
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