Paired Kidney Biopsies from the AURORA 2 Study of Voclosporin in Active Lupus Nephritis (ACR Convergence 2023) - Sep 24, 2023 - Abstract #2345; Pres time: Nov 14, 2023; 09:00 AM - 11:00 AM; Location: Poster Hall; in person; "Addition of voclosporin to mycophenolate mofetil (MMF) and low-dose glucocorticoids in the Phase 3 global AURORA 1 and AURORA 2 studies led to significantly earlier and greater reductions in proteinuria and an improved estimated glomerular filtration rate (eGFR) slope over time.To characterize the long-term renal impact of voclosporin at the histologic level, we analyzed paired kidney biopsies from a subset of patients in these studies. As expected, mean activity scores improved in both treatment arms. Importantly, exposure to voclosporin was not associated with chronic injury, with the mean index remaining stable at follow-up. Similar to the overall population, patients treated with voclosporin saw greater reductions in UPCR over 3 years of treatment; safety outcomes from this small subgroup were also consistent with outcomes in AURORA 1."
Biopsy • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease
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Samir Parikh1; Salem Almaani2; Arnon Arazi3; Huijuan Song1; Pearlly Yan1; Estela Puchulu-Campanella1; Clint Abner4; Ernie Yap4; Krista Piper4; Robert B. Huizinga5; Henry Leher4
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