RF-Driven Immune Complex Glomerulonephritis Mimicking Seronegative Lupus Nephritis: A Diagnostic Pitfall (EULAR 2026) - Mar 18, 2026 - Abstract #POS0119; E.276; I148; Pres time: Jun 4, 2026; 01:48 PM - 01:54 PM; Location: Poster Tour II; "The patient was treated with multitarget therapy including corticosteroids, mycophenolate mofetil, and hydroxychloroquine. Voclosporin was added due to partial response, resulting in gradual reduction of proteinuria and improvement of complement levels...The absence of ANA and specific immunofluorescence patterns, such as weak C1q staining and lack of IgA deposition, are key for distinguishing RF-driven IC-GN from seronegative LN. "Lupus-like" renal pathology can occur in the absence of systemic lupus erythematosus or cryoglobulinemia, underscoring the need for integrated serological and pathological assessment."
Complement-mediated Rare Disorders • Glomerulonephritis • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology
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Kei Tomura1; Hirofumi Amano1; Takayuki Kon1; Rina Takahashi 1
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