α-Aminoboronic Acid Moieties in Boro Dipeptides Modulate Proteasome Subunit Selectivity and Provide Access to Compounds with Potent Anticancer and Anti-Inflammatory Activity. (PubMed, J Med Chem) - Dec 5, 2025 - "Although their cytotoxicity to cancer cells was not improved compared to bortezomib, selected compounds proved less toxic to noncancer cells and with anti-inflammatory activity comparable to that of zetomipzomib (KZR-616). The presented boro dipeptides with tailored P1 residues provide a basis for designing subunit-selective compounds with boronic acid as the warhead and optimized P2 and/or P3 positions."
Journal • Immunology • Oncology
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Andrej Šterman; Lara Smrdel; Martina Gobec; Nika Strašek Benedik; Stane Pajk; Stanislav Gobec
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