ZDHHC9 regulates lipid metabolic reprogramming by mediating palmitoylation of ACSL3 to promote Cetuximab resistance in Colorectal Cancer. (PubMed, Exp Cell Res) - Sep 26, 2026 - "Notably, ectopic overexpression of ACSL3 effectively rescued the suppression of CRC cell proliferation induced by ZDHHC9 depletion. In conclusion, our findings establish the ZDHHC9-ACSL3 axis as a preclinically validated resistance driver and an actionable metabolic vulnerability for overcoming Cetuximab resistance in CRC."
Journal • Colorectal Cancer • Metabolic Disorders • Oncology • Solid Tumor • ACSL3 • ZDHHC9
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Jingduo Hao; Kun Song; Tiangong Wang; Yunxiao Lin; Zhaolan Xie; Zuyin Ge
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