Mechanism of electroacupuncture regulating PI3K/AKT/FoxO1 signaling pathway to improve hepatic gluconeogenesis in type 2 diabetic rats (PubMed, Zhen Ci Yan Jiu) - Sep 25, 2026 - "EA at EX-B3, ST36, and ST44 can significantly reduce blood glucose levels, increase body weight, and improve liver injury in T2DM rats. The underlying mechanism may involve activation of the hepatic PI3K/AKT/FoxO1 signaling pathway, which suppresses the expression of the downstream gluconeogenic key enzymes PEPCK and G6Pase, thereby reducing hepatic glucose output."
Journal • Preclinical • Diabetes • Hepatology • Liver Failure • Metabolic Disorders • Type 2 Diabetes Mellitus • FOXO1 • PCK2
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Aihong Yuan; Hudie Song; Jun Yang; Min Ye; Wenjing Kan
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