Angelica sinensis polysaccharide reduces macrophage FPR2 to regulate the hepatic inflammatory microenvironment and activate the PI3K/AKT signaling pathway to improve insulin resistance. (PubMed, Cytotechnology) - Sep 25, 2026 - "Further treatment with the PI3K inhibitor LY294002 blocked this protective effect...ASP improves IR in rats by downregulating FPR2 expression, inhibiting M1 macrophage-mediated hepatocyte inflammatory responses, and activating the PI3K/AKT signaling pathway. The online version contains supplementary material available at https://doi.org/10.1007/s10616-026-01071-y."
Journal • Inflammation • FPR2 • PCK2
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Bin Ruan; Hong Zhu; Jiarui Peng; Mei Cao; Zhisheng Duan
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