Selective dopamine D5 receptor activation reduces body weight% in diet-induced obese mice (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR071.07 / II1; Pres time: Nov 15, 2026; 08:00 AM - 12:00 PM; Location: WCC Halls A-C; "Grant Support NIH Grant R01MH132019; Obesity remains a major health challenge, and neural mechanisms regulating body weight and feeding behavior remain incompletely understood...Although semaglutide and tirzepatide produced greater reductions in body weight than LI-2859, the effects of LI-2859 prompted in-house evaluation of the mixed D1/D5 receptor agonist Tavapadon (0.3 or 1 mg/kg, p.o., b.i.d.) using the same mice and treatment paradigm...Selective D5 receptor activation, though producing significant reductions in weight, does not produce equivalent effects when compared to GLP-1 or GLP-1/GIP agonists while. These findings replicate previous studies showing anorectic effects of D1-like receptor agonists and suggest a specific role for selective D5 activation in DIO models."
Preclinical • CNS Disorders
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