Neuroprotective Mechanisms of Paeoniflorin in Parkinson's Models: Involvement of BDNF-Dependent PI3K/Akt and ERK/CREB Pathways. (PubMed, Curr Issues Mol Biol) - Sep 27, 2026 - "A key innovation is the dual activation and coordinated activation of the two BDNF-dependent pathways: LY294002 abolished paeoniflorin-induced BDNF/PI3K/Akt activation, while PD98059 and ERK1/2 siRNA specifically suppressed paeoniflorin-triggered phosphorylation of ERK1/2, p90RSK, and CREB. Ultimately, paeoniflorin exerts robust neuroprotection against MPTP/MPP+ neurotoxicity by synergistically activating BDNF-downstream PI3K/Akt and ERK/CREB axes. This delineation of a dual-pathway mechanism provides novel insight into the pharmacological action of paeoniflorin and supports its potential as a multifaceted therapeutic agent for Parkinson's disease."
Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • BDNF
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Bing Li; Chang Jin; Kai Song; Meizhu Zheng; Yongxing Ai; Yue Zhang; Zhifeng Cheng
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