Manganese Dioxide Nanoparticles Protect PC12 Cells Against H2O2-Induced Oxidative Stress Injury by Regulating PI3K/Akt-Mediated Autophagy. (PubMed, Pharmaceutics) - Sep 27, 2026 - "Further analysis showed that BSA-MnO2 NPs enhanced Akt phosphorylation, while LY294002, a PI3K inhibitor, suppressed Akt activation, disrupted autophagy regulation, and eliminated their neuroprotective effects. In contrast, chloroquine did not affect Akt phosphorylation, indicating that PI3K/Akt signaling acts upstream of autophagy regulation. Collectively, these findings demonstrate that BSA-MnO2 NPs protect PC12 cells against H2O2-induced oxidative injury by restoring autophagy through the PI3K/Akt signaling pathway, highlighting a potential role of BSA-MnO2 NPs in the treatment of oxidative-stress-related neurodegenerative disorders."
Journal • Alzheimer's Disease • CNS Disorders • Movement Disorders • Parkinson's Disease
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Bingfeng Liu; Chao Song; Duanyang Zhou; Ling Guo; Rihong Zhai; Song Cai; Tianlong Wang; Weijian Zeng; Xun Song; Yun Dong; Zhan-Lu Ma-Högemeier; Zhendan He
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