Computational Mapping of Hedgehog Pathway Kinase Module Predicts Node-Specific Craniofacial Phenotypes. (PubMed, Genes (Basel)) - May 4, 2026 - "This strictly in silico study identifies candidate integrated morphogenic modules whose multi-node perturbation may underlie anatomically specific craniofacial malformation patterns. Node-phenotype associations are prioritized computational hypotheses requiring experimental validation; if confirmed, the framework could inform developmental toxicity assessment, therapeutic design, and reclassification of idiopathic craniofacial anomalies."
Journal • GLI1 • GLI3 • HEY1 • HIF1A
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Karl Hörmann; Kosi Gramatikoff; Mario Milkov; Miroslav Stoykov
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