Hedgehog Inhibitor and Paclitaxel: A Phase I Trial of the Oral Hedgehog inhibitor Taladegib in Combination with Weekly Paclitaxel in Patients with Advanced Solid Tumours. (PubMed, Invest New Drugs) - May 3, 2026 - "The combination is feasible but cumulative neuropathy may limit longer term treatment. Hh signalling may be implicated in chemotherapy-induced neuropathy."
Journal • P1 data • Basal Cell Carcinoma • Brain Cancer • Medulloblastoma • Non-melanoma Skin Cancer • Oncology • Pain • Solid Tumor
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Carol Evans; Chantevy Pou; Elaine McCartney; Fiona Thomson; Iain A McNeish; Jennifer Brown; Laura Spiers; Liz-Anne Lewsley; Michelle Lockley; Rosalind Glasspool; Sarah Patricia Blagden; T R Jeffry Evans
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