Nitroxyl (HNO) therapeutics: exposure control and target engagement. (PubMed, Trends Pharmacol Sci) - Sep 9, 2026 - "However, systemic administration of these donors provides limited control over local HNO exposure or interaction with the target. This forum discusses recent approaches and challenges to control HNO generation, reshape exposure, and assess target engagement, evaluating mechanisms, maturity, constraints, and therapeutic fit."
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