Ocular safety signals of sphingosine-1-phosphate receptor modulators in postmarketing surveillance. (PubMed, Front Pharmacol) - Oct 11, 2026 - "Fingolimod had the broadest signal spectrum; macular oedema was the principal anatomically specific signal for siponimod and ozanimod. No ponesimod PT met primary criteria, and the etrasimod macular oedema estimate was sparse (n = 11)...The association remained evident after phenotype aggregation and indication-restricted analysis and was also observed in Canada Vigilance. Sparse data for newer agents and residual confounding limit comparative interpretation."
Journal • P4 data • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Macular Edema • Multiple Sclerosis • Ocular Inflammation • Ophthalmology • Ulcerative Colitis
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Jie Zhang; Jing Han; Jue Wang; Mei Fu; Nan Ma; Qingyi He; Yangjun Li
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