Epigenetic, chromatin-associated, and epitranscriptomic regulation in chronic pain: mechanisms and translational prospects. (PubMed, Front Genet) - Oct 11, 2026 - "Likewise, broad DNMT, HDAC, or histone-modifying interventions show analgesic activity mainly in animals, whereas the negative phase two trial of the HDAC6 inhibitor ricolinostat illustrates the translational gap. We therefore argue that future progress will depend on cell-resolved longitudinal multi-omics, causal epigenome editing, human tissue validation, and biomarker studies designed around prespecified clinical utility rather than statistical association alone."
Journal • Review • Pain
|