Rapid Quantification of Ceftobiprole in Human Plasma and Cerebrospinal Fluid by LC-MS/MS and Its Application in Patients with Central Nervous System Infections. (PubMed, Molecules) - May 4, 2026 - "The method was successfully applied to samples from three patients, revealing a CSF penetration range of 11.9% to 36.5%. This validated LC-MS/MS method enables simple and rapid quantification of ceftobiprole in plasma and cerebrospinal fluid, filling the gap in data on its CNS penetration and supporting routine drug concentration monitoring in critically ill patients."
Journal • Infectious Disease
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Beining Guo; Jing Zhang; Mengting Chen; Mubarak Iminjan; Muyassar Yasen; Nanyang Li; Sabahat Ablimit; Wanzhen Li; Yaxin Fan
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