Discovery of novel benzothiophenes targeting penicillin-binding proteins in gram-positive bacteria | Poster Board #1749 (ACS-Fall 2026) - Aug 24, 2026 - Abstract #4536679; Pres time: Aug 24, 2026; 09:00 PM - 11:00 PM; Location: Hall F2 - POSTERS (McCormick Place Convention Center); "We previously identified the benzothiophene compound NDM-335 as a potential inhibitor of PBP4 that overcomes PBP4-mediated resistance to ceftobiprole...Binding studies using biochemical and biophysical assays indicate interaction with PBP2 and secondary affinity for PBP4, supporting a mechanism targeting bacterial cell wall biosynthesis. Together, these findings highlight benzothiophene scaffolds as promising platforms for both antibiotic adjuvant development and direct antibacterial discovery, providing a foundation for future optimization against multidrug-resistant gram-positive pathogens."
Gram positive • Infectious Disease
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