methotrexate - Generic mfg.
cyclosporine - Generic mfg.
Anzupgo (delgocitinib) - LEO Pharma
Toctino (alitretinoin) - Basilea
Dupixent (dupilumab) - Sanofi, Regeneron
A review of pediatric chronic hand eczema with a focus on risk factors, allergens, and management (EADV 2026) - Aug 6, 2026 - Abstract #P1004; AS-1342; Pres time: Sep 30, 2026; Location: ePoster Area; "Topical calcineurin inhibitors and phototherapy offer steroid-sparring alternatives, while topical JAK inhibitors (e.g., delgocitinib) represent a promising emerging class with active trials in adolescents...Alitretinoin, methotrexate, and cyclosporine are used cautiously off-label. Dupilumab, approved for pediatric atopic dermatitis (AD), has emerged as a favoured first-line systemic therapy for P-CHE demonstrating efficacy and safety...Existing data is primarily derived from limited subgroup analyses within adult predominant trials, or from patients with atopic hand dermatitis enrolled within larger AD studies. Future research must address these gaps to inform guideline development and prioritize international consensus, with the goal of improving patient outcomes." 
Clinical • Review • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pediatrics
https://pagv3.virtual-meeting.org/eadv/eadvcongress2026/en-GB/pag/presentation/63120
 
Katie Yeung; Megan Lowe; Jessica Ho; Joshua Lowe; Sonja Molin
 
Aug 6, 2026
 
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